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State-dependent energetics of GABAA receptor modulators

Biophysical journal, 2024-07, Vol.123 (14), p.1903-1906

2024

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A potential cost of evolving epibatidine resistance in poison frogs

BMC biology, 2023-06, Vol.21 (1), p.144-144, Article 144

2023

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Interacting amino acid replacements allow poison frogs to evolve epibatidine resistance

Science (American Association for the Advancement of Science), 2017-09, Vol.357 (6357), p.1261-1266

2017

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(+)-Catharanthine potentiates the GABAA receptor by binding to a transmembrane site at the β(+)/α(-) interface near the TM2-TM3 loop

Biochemical pharmacology, 2022-05, Vol.199, p.114993-114993, Article 114993

2022

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Modulation of α1β3γ2 GABAA receptors expressed in X. laevis oocytes using a propofol photoswitch tethered to the transmembrane helix

Proceedings of the National Academy of Sciences - PNAS, 2021-02, Vol.118 (8), p.1-8

2021

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Apremilast regulates acute effects of ethanol and other GABAergic drugs via protein kinase A-dependent signaling

Neuropharmacology, 2020-11, Vol.178, p.108220-108220, Article 108220

2020

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Modulation of α1β3γ2 GABA A receptors expressed in X. laevis oocytes using a propofol photoswitch tethered to the transmembrane helix

Proceedings of the National Academy of Sciences - PNAS, 2021-02, Vol.118 (8)

2021

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Mutation of the inhibitory ethanol site in GABAA ρ1 receptors promotes tolerance to ethanol-induced motor incoordination

Neuropharmacology, 2017-09, Vol.123, p.201-209

2017

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The molecular pharmacology of volatile anesthetics

International anesthesiology clinics, 2015-01, Vol.53 (2), p.28-39

Borghese, Cecilia M

2015

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Novel Molecule Exhibiting Selective Affinity for GABAA Receptor Subtypes

Scientific reports, 2017-07, Vol.7 (1), p.1-13, Article 6230

2017

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GABAA receptor transmembrane amino acids are critical for alcohol action: disulfide cross‐linking and alkyl methanethiosulfonate labeling reveal relative location of binding sites

Journal of neurochemistry, 2014-02, Vol.128 (3), p.363-375

2014

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GABA(A) receptor transmembrane amino acids are critical for alcohol action: disulfide cross-linking and alkyl methanethiosulfonate labeling reveal relative location of binding sites

Journal of neurochemistry, 2014-02, Vol.128 (3), p.363-375

2014

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The delta subunit of gamma-aminobutyric acid type A receptors does not confer sensitivity to low concentrations of ethanol

The Journal of pharmacology and experimental therapeutics, 2006-03, Vol.316 (3), p.1360-1368

2006

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GABAA receptors containing ρ1 subunits contribute to in vivo effects of ethanol in mice

PloS one, 2014, Vol.9 (1), p.e85525-e85525

2014

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Mutation of the inhibitory ethanol site in GABA A ρ1 receptors promotes tolerance to ethanol-induced motor incoordination

Neuropharmacology, 2017-09, Vol.123, p.201-209

2017

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Studies of ethanol actions on recombinant δ-containing γ-aminobutyric acid type A receptors yield contradictory results

Alcohol (Fayetteville, N.Y.), 2007-05, Vol.41 (3), p.155-162

2007

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A transmembrane amino acid in the GABAA receptor β2 subunit critical for the actions of alcohols and anesthetics

The Journal of pharmacology and experimental therapeutics, 2010-12, Vol.335 (3), p.600

2010

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Functional validation of virtual screening for novel agents with general anesthetic action at ligand-gated ion channels

Molecular pharmacology, 2013-11, Vol.84 (5), p.670-678

2013

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Characterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols

The Journal of pharmacology and experimental therapeutics, 2012-02, Vol.340 (2), p.304-316

2012

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Identification of an Inhibitory Alcohol Binding Site in GABAA ρ1 Receptors

ACS chemical neuroscience, 2016-01, Vol.7 (1), p.100-108

2016

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Effects of Acamprosate on Neuronal Receptors and Ion Channels Expressed in Xenopus Oocytes

Alcoholism, clinical and experimental research, 2008-02, Vol.32 (2), p.188-196

2008

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Mutations M287L and Q266I in the glycine receptor α1 subunit change sensitivity to volatile anesthetics in oocytes and neurons, but not the minimal alveolar concentration in knockin mice

Anesthesiology (Philadelphia), 2012-10, Vol.117 (4), p.765-771

2012

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β3-Containing Gamma-Aminobutyric AcidA Receptors Are Not Major Targets for the Amnesic and Immobilizing Actions of Isoflurane

Anesthesia and analgesia, 2005-08, Vol.101 (2), p.412-418

2005

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Role of M2-M3 linker backbone-to-backbone hydrogen bonds in α1β2γ2l GABAA receptor gating

Biophysical journal, 2024-02, Vol.123 (3), p.160a-160a

2024

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State-dependent energetics of GABA A receptor modulators

Biophysical journal, 2024-07, Vol.123 (14), p.1903

2024

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State-dependent energetics of GABAA receptor modulators

A potential cost of evolving epibatidine resistance in poison frogs

Interacting amino acid replacements allow poison frogs to evolve epibatidine resistance

(+)-Catharanthine potentiates the GABAA receptor by binding to a transmembrane site at the β(+)/α(-) interface near the TM2-TM3 loop

Modulation of α1β3γ2 GABAA receptors expressed in X. laevis oocytes using a propofol photoswitch tethered to the transmembrane helix

Apremilast regulates acute effects of ethanol and other GABAergic drugs via protein kinase A-dependent signaling

Modulation of α1β3γ2 GABA A receptors expressed in X. laevis oocytes using a propofol photoswitch tethered to the transmembrane helix

Mutation of the inhibitory ethanol site in GABAA ρ1 receptors promotes tolerance to ethanol-induced motor incoordination

The molecular pharmacology of volatile anesthetics

Novel Molecule Exhibiting Selective Affinity for GABAA Receptor Subtypes

GABAA receptor transmembrane amino acids are critical for alcohol action: disulfide cross‐linking and alkyl methanethiosulfonate labeling reveal relative location of binding sites

GABA(A) receptor transmembrane amino acids are critical for alcohol action: disulfide cross-linking and alkyl methanethiosulfonate labeling reveal relative location of binding sites

The delta subunit of gamma-aminobutyric acid type A receptors does not confer sensitivity to low concentrations of ethanol

GABAA receptors containing ρ1 subunits contribute to in vivo effects of ethanol in mice

Mutation of the inhibitory ethanol site in GABA A ρ1 receptors promotes tolerance to ethanol-induced motor incoordination

Studies of ethanol actions on recombinant δ-containing γ-aminobutyric acid type A receptors yield contradictory results

A transmembrane amino acid in the GABAA receptor β2 subunit critical for the actions of alcohols and anesthetics

Functional validation of virtual screening for novel agents with general anesthetic action at ligand-gated ion channels

Characterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols

Identification of an Inhibitory Alcohol Binding Site in GABAA ρ1 Receptors

Effects of Acamprosate on Neuronal Receptors and Ion Channels Expressed in Xenopus Oocytes

Mutations M287L and Q266I in the glycine receptor α1 subunit change sensitivity to volatile anesthetics in oocytes and neurons, but not the minimal alveolar concentration in knockin mice

β3-Containing Gamma-Aminobutyric AcidA Receptors Are Not Major Targets for the Amnesic and Immobilizing Actions of Isoflurane

Role of M2-M3 linker backbone-to-backbone hydrogen bonds in α1β2γ2l GABAA receptor gating

State-dependent energetics of GABA A receptor modulators

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