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Formulation considerations for proteins susceptible to asparagine deamidation and aspartate isomerization

Journal of pharmaceutical sciences, 2006-11, Vol.95 (11), p.2321-2336

2006

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VEGF increases BMEC monolayer permeability by affecting occludin expression and tight junction assembly

American journal of physiology. Heart and circulatory physiology, 2001-01, Vol.280 (1), p.H434-H440

2001

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Aspartate Isomerization in the Complementarity-Determining Regions of Two Closely Related Monoclonal Antibodies

Biochemistry (Easton), 2007-02, Vol.46 (6), p.1534-1544

2007

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Editorial Invitation to Become a Reviewer for the Journal of Pharmaceutical Sciences

Journal of pharmaceutical sciences, 2018-05, Vol.107 (5), p.1209-1210

2018

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Editorial Invitation to Become a Reviewer for the Journal of Pharmaceutical Sciences

Journal of pharmaceutical sciences, 2018-05, Vol.107 (5), p.1209

Borchardt, Ronald T

2018

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Effects of Poly(ethylene glycol) on Efflux Transporter Activity in Caco‐2 Cell Monolayers

Journal of pharmaceutical sciences, 2002-09, Vol.91 (9), p.1980-1990

2002

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Absorption Barriers in the Rat Intestinal Mucosa: 1. Application of an In Situ Perfusion Model to Simultaneously Assess Drug Permeation and Metabolism

Journal of pharmaceutical sciences, 2010-02, Vol.99 (2), p.982-998

2010

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Enzymes involved in the bioconversion of ester-based prodrugs

Journal of pharmaceutical sciences, 2006-06, Vol.95 (6), p.1177-1195

2006

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Hidalgo, I. J., Raub, T. J., and Borchardt, R. T.: Characterization of the Human Colon Carcinoma Cell Line (Caco-2) as a Model System for Intestinal Epithelial Permeability, Gastroenterology, 96, 736–749, 1989—The Backstory

The AAPS journal, 2011-09, Vol.13 (3), p.323-327

Borchardt, Ronald T.

2011

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A kinetic evaluation of the absorption, efflux, and metabolism of verapamil in the autoperfused rat jejunum

The Journal of pharmacology and experimental therapeutics, 2003-04, Vol.305 (1), p.151

2003

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Improvement of oral peptide bioavailability: Peptidomimetics and prodrug strategies

Advanced drug delivery reviews, 1997-09, Vol.27 (2), p.235-256

1997

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Chemical instability of protein pharmaceuticals: Mechanisms of oxidation and strategies for stabilization

Biotechnology and bioengineering, 1995-12, Vol.48 (5), p.490-500

1995

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Bidirectional transport of rhodamine 123 and Hoechst 33342, fluorescence probes of the binding sites on P-glycoprotein, across MDCK–MDR1 cell monolayers

Journal of pharmaceutical sciences, 2004-05, Vol.93 (5), p.1185-1194

2004

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Optimizing oral absorption of peptides using prodrug strategies

Journal of controlled release, 1999-11, Vol.62 (1-2), p.231-238

Borchardt, Ronald T

1999

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Isolation and characterization of Caco-2 subclones expressing high levels of multidrug resistance protein efflux transporter

Pharmaceutical research, 2003-02, Vol.20 (2), p.161-168

2003

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In vitro stability and in vivo pharmacokinetic studies of a model opioid peptide, H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (DADLE), and its cyclic prodrugs

The Journal of pharmacology and experimental therapeutics, 2002-11, Vol.303 (2), p.840

2002

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Absorption Barriers in the Rat Intestinal Mucosa. 3: Effects of Polyethoxylated Solubilizing Agents on Drug Permeation and Metabolism

Journal of pharmaceutical sciences, 2010-02, Vol.99 (2), p.1016-1027

2010

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Phe-Gly Dipeptidomimetics Designed for the Di-/Tripeptide Transporters PEPT1 and PEPT2: Synthesis and Biological Investigations

Journal of medicinal chemistry, 2004-02, Vol.47 (4), p.1060-1069

2004

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A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells

Pharmaceutical research, 2001-02, Vol.18 (2), p.171-176

2001

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Factors that Restrict the Cell Permeation of Cyclic Prodrugs of an Opioid Peptide, Part 4: Characterization of the Biopharmaceutical and Physicochemical Properties of Two New Cyclic Prodrugs Designed to be Stable to Oxidative Metabolism by Cytochrome P-450 Enzymes in the Intestinal Mucosa

Journal of pharmaceutical sciences, 2012-09, Vol.101 (9), p.3500-3510

2012

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Racemization of an Asparagine Residue during Peptide Deamidation

Journal of the American Chemical Society, 2003-09, Vol.125 (38), p.11486-11487

2003

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Effect of ‘pH’ on the rate of asparagine deamidation in polymeric formulations: ‘pH’–rate profile

Journal of pharmaceutical sciences, 2001-02, Vol.90 (2), p.141-156

2001

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Journal of Pharmaceutical Sciences. Editorial

Journal of pharmaceutical sciences, 2010-08, Vol.99 (8), p.3279-3280

Borchardt, Ronald T

2010

Volltextzugriff (PDF)

Factors that Restrict the Cell Permeation of Cyclic Prodrugs of an Opioid Peptide, Part 3: Synthesis of Analogs Designed to have Improved Stability to Oxidative Metabolism

Journal of pharmaceutical sciences, 2012-09, Vol.101 (9), p.3486-3499

2012

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Journal of Pharmaceutical Sciences. Editorial

Journal of pharmaceutical sciences, 2010-02, Vol.99 (2), p.567-567

Borchardt, Ronald T

2010

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Formulation considerations for proteins susceptible to asparagine deamidation and aspartate isomerization

VEGF increases BMEC monolayer permeability by affecting occludin expression and tight junction assembly

Aspartate Isomerization in the Complementarity-Determining Regions of Two Closely Related Monoclonal Antibodies

Editorial Invitation to Become a Reviewer for the Journal of Pharmaceutical Sciences

Editorial Invitation to Become a Reviewer for the Journal of Pharmaceutical Sciences

Effects of Poly(ethylene glycol) on Efflux Transporter Activity in Caco‐2 Cell Monolayers

Absorption Barriers in the Rat Intestinal Mucosa: 1. Application of an In Situ Perfusion Model to Simultaneously Assess Drug Permeation and Metabolism

Enzymes involved in the bioconversion of ester-based prodrugs

Hidalgo, I. J., Raub, T. J., and Borchardt, R. T.: Characterization of the Human Colon Carcinoma Cell Line (Caco-2) as a Model System for Intestinal Epithelial Permeability, Gastroenterology, 96, 736–749, 1989—The Backstory

A kinetic evaluation of the absorption, efflux, and metabolism of verapamil in the autoperfused rat jejunum

Improvement of oral peptide bioavailability: Peptidomimetics and prodrug strategies

Chemical instability of protein pharmaceuticals: Mechanisms of oxidation and strategies for stabilization

Bidirectional transport of rhodamine 123 and Hoechst 33342, fluorescence probes of the binding sites on P-glycoprotein, across MDCK–MDR1 cell monolayers

Optimizing oral absorption of peptides using prodrug strategies

Isolation and characterization of Caco-2 subclones expressing high levels of multidrug resistance protein efflux transporter

In vitro stability and in vivo pharmacokinetic studies of a model opioid peptide, H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (DADLE), and its cyclic prodrugs

Absorption Barriers in the Rat Intestinal Mucosa. 3: Effects of Polyethoxylated Solubilizing Agents on Drug Permeation and Metabolism

Phe-Gly Dipeptidomimetics Designed for the Di-/Tripeptide Transporters PEPT1 and PEPT2: Synthesis and Biological Investigations

A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells

Factors that Restrict the Cell Permeation of Cyclic Prodrugs of an Opioid Peptide, Part 4: Characterization of the Biopharmaceutical and Physicochemical Properties of Two New Cyclic Prodrugs Designed to be Stable to Oxidative Metabolism by Cytochrome P-450 Enzymes in the Intestinal Mucosa

Racemization of an Asparagine Residue during Peptide Deamidation

Effect of ‘pH’ on the rate of asparagine deamidation in polymeric formulations: ‘pH’–rate profile

Journal of Pharmaceutical Sciences. Editorial

Factors that Restrict the Cell Permeation of Cyclic Prodrugs of an Opioid Peptide, Part 3: Synthesis of Analogs Designed to have Improved Stability to Oxidative Metabolism

Journal of Pharmaceutical Sciences. Editorial

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