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Novel Inducers of Fetal Globin Identified through High Throughput Screening (HTS) Are Active In Vivo in Anemic Baboons and Transgenic Mice

PloS one, 2015-12, Vol.10 (12), p.e0144660-e0144660

2015

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Butyrate histone deacetylase inhibitors

BioResearch open access, 2012-08, Vol.1 (4), p.192-198

2012

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A phase 2 trial of HQK-1001 in HbE-β thalassemia demonstrates HbF induction and reduced anemia

Blood, 2014-03, Vol.123 (12), p.1956-1957

2014

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An oral HemokineTM, α-methylhydrocinnamate, enhances myeloid and neutrophil recovery following irradiation in vivo

Blood cells, molecules, & diseases, 2017-03, Vol.63, p.1-8

2017

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Evaluation of Safety and Pharmacokinetics of Sodium 2,2 Dimethylbutyrate, a Novel Short Chain Fatty Acid Derivative, in a Phase 1, Double-Blind, Placebo-Controlled, Single-Dose, and Repeat-Dose Studies in Healthy Volunteers

Journal of clinical pharmacology, 2011-08, Vol.51 (8), p.1186-1194

2011

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Short-chain fatty acids induce γ-globin gene expression by displacement of a HDAC3-NCoR repressor complex

Blood, 2006-11, Vol.108 (9), p.3179-3186

2006

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Short-chain fatty acid derivatives induce fetal globin expression and erythropoiesis in vivo

Blood, 2002-12, Vol.100 (13), p.4640-4648

2002

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Receptor for the globular heads of C1q (gC1q‐R, p33, hyaluronan‐binding protein) is preferentially expressed by adenocarcinoma cells

International journal of cancer, 2004-07, Vol.110 (5), p.741-750

2004

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Erythroid Kruppel-like factor (EKLF) is recruited to the γ-globin gene promoter as a co-activator and is required for γ-globin gene induction by short-chain fatty acid derivatives

European journal of haematology, 2009-06, Vol.82 (6), p.466-476

2009

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Novel therapeutic candidates, identified by molecular modeling, induce γ-globin gene expression in vivo

Blood cells, molecules, & diseases, 2011-08, Vol.47 (2), p.107-116

2011

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Induction of Fetal Globin in β-Thalassemia: Cellular Obstacles and Molecular Progress

Annals of the New York Academy of Sciences, 2005-01, Vol.1054 (1), p.257-265

2005

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Short-chain fatty acid derivatives stimulate cell proliferation and induce STAT-5 activation

Blood, 2001-05, Vol.97 (10), p.3259-3267

2001

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Effects of the IMP-dehydrogenase inhibitor, Tiazofurin, in bcr-abl positive acute myelogenous leukemia : Part I. In vivo studies

Leukemia research, 2004-11, Vol.28 (11), p.1125-1136

2004

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Identification of Novel Small-molecule Inducers of Fetal Hemoglobin Using Pharmacophore and 'PSEUDO' Receptor Models

Chemical biology & drug design, 2006-05, Vol.67 (5), p.318-328

2006

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Enhancement of growth and survival and alterations in Bcl-family proteins in β-thalassemic erythroid progenitors by novel short-chain fatty acid derivatives

Blood cells, molecules, & diseases, 2005-09, Vol.35 (2), p.217-226

2005

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Mechanism of inactivation of human O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine

Biochemistry (Easton), , Vol.32 (45), p.11998-12006

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A randomized phase I/II trial of HQK‐1001, an oral fetal globin gene inducer, in β‐thalassaemia intermedia and HbE/β‐thalassaemia

British journal of haematology, 2013-05, Vol.161 (4), p.587-593

2013

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An oral Hemokine™, α-methylhydrocinnamate, enhances myeloid and neutrophil recovery following irradiation in vivo

Blood cells, molecules, & diseases, 2017-03, Vol.63, p.1-8

2017

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An Approach for Tailoring Diverse Therapeutic Inducers of Fetal Globin to Genetic Modifier Profiles

Blood, 2011-11, Vol.118 (21), p.3188-3188

2011

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Next Generation Clinical-Stage HbF Inducers Exhibit Multiple Molecular Actions In Vitro and In Vivo and Offer Personalized Therapeutic Regimens

Blood, 2013-11, Vol.122 (21), p.560-560

2013

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A randomized phase I/II trial of HQK ‐1001, an oral fetal globin gene inducer, in β‐thalassaemia intermedia and H b E /β‐thalassaemia

British journal of haematology, 2013-05, Vol.161 (4), p.587-593

2013

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Effects of the IMP-dehydrogenase inhibitor, Tiazofurin, in bcr-abl positive acute myelogenous leukemia

Leukemia research, 2004-11, Vol.28 (11), p.1125-1136

2004

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Identification of New and Diverse Inducers of Fetal Hemoglobin with High Throughput Screening (HTS)

Blood, 2010-11, Vol.116 (21), p.4277-4277

2010

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HQK-1001 Has Additive HbF-Inducing Activity in Combination with Hydroxyurea and Decitabine

Blood, 2009-11, Vol.114 (22), p.977-977

2009

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An oral Hemokine TM , α-methylhydrocinnamate, enhances myeloid and neutrophil recovery following irradiation in vivo

Blood cells, molecules, & diseases, 2017-03, Vol.63, p.1

2017

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Novel Inducers of Fetal Globin Identified through High Throughput Screening (HTS) Are Active In Vivo in Anemic Baboons and Transgenic Mice

Butyrate histone deacetylase inhibitors

A phase 2 trial of HQK-1001 in HbE-β thalassemia demonstrates HbF induction and reduced anemia

An oral HemokineTM, α-methylhydrocinnamate, enhances myeloid and neutrophil recovery following irradiation in vivo

Evaluation of Safety and Pharmacokinetics of Sodium 2,2 Dimethylbutyrate, a Novel Short Chain Fatty Acid Derivative, in a Phase 1, Double-Blind, Placebo-Controlled, Single-Dose, and Repeat-Dose Studies in Healthy Volunteers

Short-chain fatty acids induce γ-globin gene expression by displacement of a HDAC3-NCoR repressor complex

Short-chain fatty acid derivatives induce fetal globin expression and erythropoiesis in vivo

Receptor for the globular heads of C1q (gC1q‐R, p33, hyaluronan‐binding protein) is preferentially expressed by adenocarcinoma cells

Erythroid Kruppel-like factor (EKLF) is recruited to the γ-globin gene promoter as a co-activator and is required for γ-globin gene induction by short-chain fatty acid derivatives

Novel therapeutic candidates, identified by molecular modeling, induce γ-globin gene expression in vivo

Induction of Fetal Globin in β-Thalassemia: Cellular Obstacles and Molecular Progress

Short-chain fatty acid derivatives stimulate cell proliferation and induce STAT-5 activation

Effects of the IMP-dehydrogenase inhibitor, Tiazofurin, in bcr-abl positive acute myelogenous leukemia : Part I. In vivo studies

Identification of Novel Small-molecule Inducers of Fetal Hemoglobin Using Pharmacophore and 'PSEUDO' Receptor Models

Enhancement of growth and survival and alterations in Bcl-family proteins in β-thalassemic erythroid progenitors by novel short-chain fatty acid derivatives

Mechanism of inactivation of human O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine

A randomized phase I/II trial of HQK‐1001, an oral fetal globin gene inducer, in β‐thalassaemia intermedia and HbE/β‐thalassaemia

An oral Hemokine™, α-methylhydrocinnamate, enhances myeloid and neutrophil recovery following irradiation in vivo

An Approach for Tailoring Diverse Therapeutic Inducers of Fetal Globin to Genetic Modifier Profiles

Next Generation Clinical-Stage HbF Inducers Exhibit Multiple Molecular Actions In Vitro and In Vivo and Offer Personalized Therapeutic Regimens

A randomized phase I/II trial of HQK ‐1001, an oral fetal globin gene inducer, in β‐thalassaemia intermedia and H b E /β‐thalassaemia

Effects of the IMP-dehydrogenase inhibitor, Tiazofurin, in bcr-abl positive acute myelogenous leukemia

Identification of New and Diverse Inducers of Fetal Hemoglobin with High Throughput Screening (HTS)

HQK-1001 Has Additive HbF-Inducing Activity in Combination with Hydroxyurea and Decitabine

An oral Hemokine TM , α-methylhydrocinnamate, enhances myeloid and neutrophil recovery following irradiation in vivo

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