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Structural Characterization of the D179N and D179Y Variants of KPC-2 β-Lactamase: Ω-Loop Destabilization as a Mechanism of Resistance to Ceftazidime-Avibactam

Antimicrobial agents and chemotherapy, 2022-04, Vol.66 (4), p.e0241421-e0241421

2022

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In Vitro Discordance with In Vivo Activity: Humanized Exposures of Ceftazidime-Avibactam, Aztreonam, and Tigecycline Alone and in Combination against New Delhi Metallo-β-Lactamase-Producing Klebsiella pneumoniae in a Murine Lung Infection Model

Antimicrobial agents and chemotherapy, 2017-07, Vol.61 (7)

2017

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New agents for the treatment of infections with Gram-negative bacteria: restoring the miracle or false dawn?

Clinical microbiology and infection, 2017-10, Vol.23 (10), p.704-712

2017

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Acinetobacter quorum sensing contributes to inflammation-induced inhibition of orthopaedic implant osseointegration

European Cells and Materials, 2022-06, Vol.43, p.267-276

2022

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Analysis of the Structure and Function of FOX-4 Cephamycinase

Antimicrobial agents and chemotherapy, 2016-02, Vol.60 (2), p.717-728

2016

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10 x '20 Progress--development of new drugs active against gram-negative bacilli: an update from the Infectious Diseases Society of America

Clinical infectious diseases, 2013-06, Vol.56 (12), p.1685-1694

2013

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Outcome of Cephalosporin Treatment for Serious Infections Due to Apparently Susceptible Organisms Producing Extended-Spectrum β-Lactamases: Implications for the Clinical Microbiology Laboratory

Journal of Clinical Microbiology, 2001-06, Vol.39 (6), p.2206-2212

2001

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A Primer on AmpC β-Lactamases: Necessary Knowledge for an Increasingly Multidrug-resistant World

Clinical infectious diseases, 2019-09, Vol.69 (8), p.1446-1455

2019

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Successful treatment of a disseminated infection with extensively drug‐resistant Klebsiella pneumoniae in a liver transplant recipient with a fosfomycin‐based multidrug regimen

Transplant infectious disease, 2016-10, Vol.18 (5), p.777-781

2016

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Spectrum of excess mortality due to carbapenem-resistant Klebsiella pneumoniae infections

Clinical microbiology and infection, 2016-06, Vol.22 (6), p.513-519

2016

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Exploring avibactam and relebactam inhibition of Klebsiella pneumoniae carbapenemase D179N variant: role of the Ω loop-held deacylation water

Antimicrobial agents and chemotherapy, 2023-10, Vol.67 (10), p.e0035023-e0035023

2023

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Broad Resistance Due to Plasmid-Mediated AmpC β-Lactamases in Clinical Isolates of Escherichia coli

Clinical infectious diseases, 2002-07, Vol.35 (2), p.140-145

2002

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Dual β-Lactam Combinations Highly Active against Mycobacterium abscessus Complex In Vitro

mBio, 2019-02, Vol.10 (1)

2019

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Fulminant endocarditis and disseminated infection caused by carbapenem‐resistant Acinetobacter baumannii in a renal‐pancreas transplant recipient

Transplant infectious disease, 2015-04, Vol.17 (2), p.289-296

2015

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Tigecycline therapy for carbapenem-resistant Klebsiella pneumoniae (CRKP) bacteriuria leads to tigecycline resistance

Clinical microbiology and infection, 2014-12, Vol.20 (12), p.O1117-O1120

2014

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"Silent" Dissemination of Klebsiella pneumoniae Isolates Bearing K. pneumoniae Carbapenemase in a Long-term Care Facility for Children and Young Adults in Northeast Ohio

Clinical infectious diseases, 2012-05, Vol.54 (9), p.1314-1321

2012

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Streptococcus anginosus (Streptococcus milleri Group) Pyomyositis in a 50-Year-Old Man with Acquired Immunodeficiency Syndrome: Case Report and Review of Literature

Infection, 2010-02, Vol.38 (1), p.65-68

2010

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Isolated pulmonic valve infective endocarditis: a persistent challenge

Infection, 2004-06, Vol.32 (3), p.170-175

2004

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Epidemiology and genotypic characterisation of dissemination patterns of uropathogenic Escherichia coli in a community

Epidemiology and infection, 2019-01, Vol.147, p.e148-e148, Article e148

2019

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High-Level Expression of Chromosomally Encoded SHV-1 β-Lactamase and an Outer Membrane Protein Change Confer Resistance to Ceftazidime and Piperacillin- Tazobactam in a Clinical Isolate of Klebsiella pneumoniae

Antimicrobial Agents and Chemotherapy, 2000-02, Vol.44 (2), p.362-367

2000

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Inhibition of the SHV-1 β-Lactamase by Sulfones: Crystallographic Observation of Two Reaction Intermediates with Tazobactam

Biochemistry (Easton), 2001-02, Vol.40 (6), p.1861-1866

2001

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Extended-Spectrum -Lactamase-Producing Enterobacteriaceae in Children: Old Foe, Emerging Threat

Clinical infectious diseases, 2015-01

2015

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Antibiotic Therapy for Klebsiella pneumoniae Bacteremia: Implications of Production of Extended-Spectrum β-Lactamases

Clinical infectious diseases, 2004-07, Vol.39 (1), p.31-37

2004

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Multiple Antibiotic-resistant Bacteria in Long-term-care Facilities: An Emerging Problem in the Practice of Infectious Diseases

Clinical infectious diseases, 2000-12, Vol.31 (6), p.1414-1422

Bonomo, Robert A.

2000

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Effect of oral Bacillus coagulans administration on the density of vancomycin‐resistant enterococci in the stool of colonized mice

Letters in applied microbiology, 2001-07, Vol.33 (1), p.84-88

2001

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Structural Characterization of the D179N and D179Y Variants of KPC-2 β-Lactamase: Ω-Loop Destabilization as a Mechanism of Resistance to Ceftazidime-Avibactam

In Vitro Discordance with In Vivo Activity: Humanized Exposures of Ceftazidime-Avibactam, Aztreonam, and Tigecycline Alone and in Combination against New Delhi Metallo-β-Lactamase-Producing Klebsiella pneumoniae in a Murine Lung Infection Model

New agents for the treatment of infections with Gram-negative bacteria: restoring the miracle or false dawn?

Acinetobacter quorum sensing contributes to inflammation-induced inhibition of orthopaedic implant osseointegration

Analysis of the Structure and Function of FOX-4 Cephamycinase

10 x '20 Progress--development of new drugs active against gram-negative bacilli: an update from the Infectious Diseases Society of America

Outcome of Cephalosporin Treatment for Serious Infections Due to Apparently Susceptible Organisms Producing Extended-Spectrum β-Lactamases: Implications for the Clinical Microbiology Laboratory

A Primer on AmpC β-Lactamases: Necessary Knowledge for an Increasingly Multidrug-resistant World

Successful treatment of a disseminated infection with extensively drug‐resistant Klebsiella pneumoniae in a liver transplant recipient with a fosfomycin‐based multidrug regimen

Spectrum of excess mortality due to carbapenem-resistant Klebsiella pneumoniae infections

Exploring avibactam and relebactam inhibition of Klebsiella pneumoniae carbapenemase D179N variant: role of the Ω loop-held deacylation water

Broad Resistance Due to Plasmid-Mediated AmpC β-Lactamases in Clinical Isolates of Escherichia coli

Dual β-Lactam Combinations Highly Active against Mycobacterium abscessus Complex In Vitro

Fulminant endocarditis and disseminated infection caused by carbapenem‐resistant Acinetobacter baumannii in a renal‐pancreas transplant recipient

Tigecycline therapy for carbapenem-resistant Klebsiella pneumoniae (CRKP) bacteriuria leads to tigecycline resistance

"Silent" Dissemination of Klebsiella pneumoniae Isolates Bearing K. pneumoniae Carbapenemase in a Long-term Care Facility for Children and Young Adults in Northeast Ohio

Streptococcus anginosus (Streptococcus milleri Group) Pyomyositis in a 50-Year-Old Man with Acquired Immunodeficiency Syndrome: Case Report and Review of Literature

Isolated pulmonic valve infective endocarditis: a persistent challenge

Epidemiology and genotypic characterisation of dissemination patterns of uropathogenic Escherichia coli in a community

High-Level Expression of Chromosomally Encoded SHV-1 β-Lactamase and an Outer Membrane Protein Change Confer Resistance to Ceftazidime and Piperacillin- Tazobactam in a Clinical Isolate of Klebsiella pneumoniae

Inhibition of the SHV-1 β-Lactamase by Sulfones: Crystallographic Observation of Two Reaction Intermediates with Tazobactam

Extended-Spectrum -Lactamase-Producing Enterobacteriaceae in Children: Old Foe, Emerging Threat

Antibiotic Therapy for Klebsiella pneumoniae Bacteremia: Implications of Production of Extended-Spectrum β-Lactamases

Multiple Antibiotic-resistant Bacteria in Long-term-care Facilities: An Emerging Problem in the Practice of Infectious Diseases

Effect of oral Bacillus coagulans administration on the density of vancomycin‐resistant enterococci in the stool of colonized mice

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