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Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation

The Journal of immunology (1950), 2016-09, Vol.197 (6), p.2421-2433

2016

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Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals

Chemical research in toxicology, 2017-05, Vol.30 (5), p.1219-1229

2017

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PF-1355, a mechanism-based myeloperoxidase inhibitor, prevents immune complex vasculitis and anti-glomerular basement membrane glomerulonephritis

The Journal of pharmacology and experimental therapeutics, 2015-05, Vol.353 (2), p.288-298

2015

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Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation

eLife, 2019-10, Vol.8

2019

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Human drug‐induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump

Hepatology (Baltimore, Md.), 2014-09, Vol.60 (3), p.1015-1022

2014

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Activation of the G-Protein-Coupled Receptor 119: A Conformation-Based Hypothesis for Understanding Agonist Response

Journal of medicinal chemistry, 2011-03, Vol.54 (6), p.1948-1952

2011

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Oxidative Metabolism of a Quinoxaline Derivative by Xanthine Oxidase in Rodent Plasma

Chemical research in toxicology, 2011-12, Vol.24 (12), p.2207-2216

2011

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Phase I study of PF‐04895162, a Kv7 channel opener, reveals unexpected hepatotoxicity in healthy subjects, but not rats or monkeys: clinical evidence of disrupted bile acid homeostasis

Pharmacology research & perspectives, 2019-02, Vol.7 (1), p.e00467-n/a

2019

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Synthesis and SAR of 1,2,3,4-tetrahydroisoquinolin-1-ones as novel G-protein-coupled receptor 40 (GPR40) antagonists

Bioorganic & medicinal chemistry letters, 2009-05, Vol.19 (9), p.2400-2403

2009

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Design and evaluation of a 2-(2,3,6-trifluorophenyl)acetamide derivative as an agonist of the GPR119 receptor

Bioorganic & medicinal chemistry letters, 2011-03, Vol.21 (5), p.1306-1309

2011

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Correction to Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals

Chemical research in toxicology, 2017-06, Vol.30 (6), p.1365-1365

2017

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Assessment of Bile Salt Export Pump (BSEP) Inhibition in Membrane Vesicles Using Radioactive and LC/MS‐Based Detection Methods

Current Protocols in Toxicology, 2017-02, Vol.71 (1), p.14.14.1-14.14.20

2017

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Design and Synthesis of Diazatricyclodecane Agonists of the G‑Protein-Coupled Receptor 119

Journal of medicinal chemistry, 2013-01, Vol.56 (1), p.301-319

2013

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From partial to full agonism: Identification of a novel 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole as a full agonist of the human GPR119 receptor

Bioorganic & medicinal chemistry letters, 2013-01, Vol.23 (1), p.194-197

2013

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Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities

Chemistry & biology, 2015-12, Vol.22 (12), p.1588-1596

2015

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Resistance mapping and mode of action of a novel class of antibacterial anthranilic acids: evidence for disruption of cell wall biosynthesis

Journal of antimicrobial chemotherapy, 2008-10, Vol.62 (4), p.720-729

2008

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Correction: Design and chemoproteomic functional characterization of a chemical probe targeted to bromodomains of BET family proteins

MedChemComm, 2015-01, Vol.6 (1), p.247-247

2015

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Development of a Fluorescence Polarization Assay for Peptidyl–tRNA Hydrolase

Analytical biochemistry, 2002-07, Vol.306 (1), p.8-16

2002

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Expression, Purification, and Characterization of Peptidyl-tRNA Hydrolase from Staphylococcus aureus

Protein expression and purification, 2002-02, Vol.24 (1), p.123-130

2002

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Adding Precise Nanoliter Volume Capabilities to Liquid-Handling Automation for Compound Screening Experimentation

Journal of Laboratory Automation, 2011-06, Vol.16 (3), p.221-228

2011

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Synthesis of 2,6-disubstituted-7,8-dihydro-6H-pyrano[2,3-6]pyrazines

Tetrahedron letters, 2012-02, Vol.53 (7), p.852-853

2012

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Design and chemoproteomic functional characterization of a chemical probe targeted to bromodomains of BET family proteins

MedChemComm, 2014-12, Vol.5 (12), p.1871-1878

2014

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Design and chemoproteomic functional characterization of a chemical probe targeted to bromodomains of BET family proteinsElectronic supplementary information (ESI) available: Details of the chemical synthesis, biological methods, supplementary tables and supplementary references. See DOI: 10.1039/c4md00259h

2014-11

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Direct photocapture of bromodomains using tropolone chemical probes

MedChemComm, 2015-01, Vol.6 (6), p.1018-1023

2015

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Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation

Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals

PF-1355, a mechanism-based myeloperoxidase inhibitor, prevents immune complex vasculitis and anti-glomerular basement membrane glomerulonephritis

Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation

Human drug‐induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump

Activation of the G-Protein-Coupled Receptor 119: A Conformation-Based Hypothesis for Understanding Agonist Response

Oxidative Metabolism of a Quinoxaline Derivative by Xanthine Oxidase in Rodent Plasma

Phase I study of PF‐04895162, a Kv7 channel opener, reveals unexpected hepatotoxicity in healthy subjects, but not rats or monkeys: clinical evidence of disrupted bile acid homeostasis

Synthesis and SAR of 1,2,3,4-tetrahydroisoquinolin-1-ones as novel G-protein-coupled receptor 40 (GPR40) antagonists

Design and evaluation of a 2-(2,3,6-trifluorophenyl)acetamide derivative as an agonist of the GPR119 receptor

Correction to Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals

Discovery of 2‑(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)‑yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases

Assessment of Bile Salt Export Pump (BSEP) Inhibition in Membrane Vesicles Using Radioactive and LC/MS‐Based Detection Methods

Design and Synthesis of Diazatricyclodecane Agonists of the G‑Protein-Coupled Receptor 119

From partial to full agonism: Identification of a novel 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole as a full agonist of the human GPR119 receptor

Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities

Resistance mapping and mode of action of a novel class of antibacterial anthranilic acids: evidence for disruption of cell wall biosynthesis

Correction: Design and chemoproteomic functional characterization of a chemical probe targeted to bromodomains of BET family proteins

Development of a Fluorescence Polarization Assay for Peptidyl–tRNA Hydrolase

Expression, Purification, and Characterization of Peptidyl-tRNA Hydrolase from Staphylococcus aureus

Adding Precise Nanoliter Volume Capabilities to Liquid-Handling Automation for Compound Screening Experimentation

Synthesis of 2,6-disubstituted-7,8-dihydro-6H-pyrano[2,3-6]pyrazines

Design and chemoproteomic functional characterization of a chemical probe targeted to bromodomains of BET family proteins

Direct photocapture of bromodomains using tropolone chemical probes

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