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Preclinical pharmacology of sugammadex

Journal of critical care, 2009-03, Vol.24 (1), p.29-35

2009

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Cyclodextrin-Derived Host Molecules as Reversal Agents for the Neuromuscular Blocker Rocuronium Bromide: Synthesis and Structure−Activity Relationships

Journal of medicinal chemistry, 2002-04, Vol.45 (9), p.1806-1816

2002

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Reversal of rocuronium-induced neuromuscular block by sugammadex is independent of renal perfusion in anesthetized cats

Journal of anesthesia, 2011-04, Vol.25 (2), p.241-246

2011

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Sugammadex reverses neuromuscular block induced by 3-desacetyl-vecuronium, an active metabolite of vecuronium, in the anaesthetised rhesus monkey

European journal of anaesthesiology, 2011-04, Vol.28 (4), p.265-272

2011

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Reversal of Neuromusclar Blockade and Simultaneous Increase in Plasma Rocuronium Concentration after the Intravenous Infusion of the Novel Reversal Agent Org 25970

Anesthesiology (Philadelphia), 2003-09, Vol.99 (3), p.632-637

2003

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Reversal of neuromuscular blockade and simultaneous increase in plasma Rocuronium concentration after the intravenous infusion of the novel reversal agent Org 25969

Anesthesiology (Philadelphia), 2003-09, Vol.99 (3), p.632-637

2003

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A novel concept of reversing neuromuscular block: chemical encapsulation of rocuronium bromide by a cyclodextrin-based synthetic host

Angewandte Chemie International Edition, 2002-01, Vol.41 (2), p.266-270

2002

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A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host

Angewandte Chemie (International ed.), 2002-01, Vol.41 (2), p.265-270

2002

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Reversal of profound rocuronium neuromuscular blockade by sugammadex in anesthetized rhesus monkeys

Anesthesiology (Philadelphia), 2006-04, Vol.104 (4), p.718-723

2006

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Selective relaxant binding agents for reversal of neuromuscular blockade

Current opinion in pharmacology, 2007-06, Vol.7 (3), p.298-302

2007

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(1)-2 The discovery and preclinical development of sugammadex

The Journal of Japan Society for Clinical Anesthesia, 2010, Vol.30 (6), p.S216-S216

2010

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Synthesis and evaluation of N-3 substituted phenoxypropyl piperidine benzimidazol-2-one analogues as NOP receptor agonists with analgesic and sedative properties

Bioorganic & medicinal chemistry, 2007-02, Vol.15 (4), p.1828-1847

2007

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Org 25969 Causes Rapid Reversal of Rocuronium-Induced Neuromuscular Block, Independent of Acid-Base Status: 2002[A-1009

Anesthesiology (Philadelphia), 2002-09, Vol.96 (Sup 2), p.A1009

2002

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2- O-Substituted Cyclodextrins as Reversal Agents for the Neuromuscular Blocker Rocuronium Bromide

Bioorganic & medicinal chemistry, 2002-06, Vol.10 (6), p.1819-1827

2002

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A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host

Angewandte Chemie, 2002-01, Vol.114 (2), p.275-280

2002

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Parallel solid-phase synthesis of zatebradine analogues as potential If channel blockers

Bioorganic & medicinal chemistry letters, 2001-09, Vol.11 (17), p.2351-2354

2001

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Effects of 5-Hydroxytryptamine on Capillary and Arteriovenous Anastomotic Blood Flow in the Human Hand and Forearm and in the Pig Hind Leg

Journal of cardiovascular pharmacology, 1991-02, Vol.17 (2), p.316-324

1991

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Parallel solid-Phase synthesis of zatebradine analogues as potential I f channel blockers

Bioorganic & medicinal chemistry letters, 2001-09, Vol.11 (17), p.2351-2354

2001

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A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host The discovery of Org 25969 is the result of teamwork with contributions from a number of scientists both inside Organon and outside the company. We would like in particular to acknowledge the following scientists for their invaluable contributions: E. Hutchinson, D. Stevenson, R. Roy, and J. Pick for scaling-up the synthesis; F. Hope, S. Miller, and R. Mason for v

Angewandte Chemie International Edition, 2002-01, Vol.41 (2), p.265

2002

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Carotid haemodynamics in pigs during infusions of 8‐O‐DPAT: reduction in arteriovenous shunting is mediated by 5‐HT1‐like receptors

British journal of pharmacology, 1989-01, Vol.96 (1), p.125-132

1989

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Constriction of porcine arteriovenous anastomoses by indorenate is unrelated to 5-HT1A, 5-HT1B, 5-HT1C or 5-HT1D receptor

European journal of pharmacology, 1990-11, Vol.190 (1-2), p.167-176

1990

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Carotid haemodynamics in pigs during infusions of 8‐O‐DPAT: reduction in arteriovenous shunting is mediated by 5‐HT 1 ‐like receptors

British journal of pharmacology, 1989-01, Vol.96 (1), p.125-132

1989

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Characterization of 5-hydroxytryptamine receptors in the cranial vasculature

Cephalalgia, 1989-01, Vol.9 (9_suppl), p.15-22

1989

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Characterization of 5-Hydroxytryptamine Receptors in the Cranial Vasculature

Cephalalgia, 1989-09, Vol.9 (9_suppl), p.15-22

1989

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Reduction of cephalic arteriovenous shunting by ergotamine is not mediated by 5‐HT1‐like or 5‐HT2 receptors

British journal of pharmacology, 1989-06, Vol.97 (2), p.383-390

1989

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Preclinical pharmacology of sugammadex

Cyclodextrin-Derived Host Molecules as Reversal Agents for the Neuromuscular Blocker Rocuronium Bromide: Synthesis and Structure−Activity Relationships

Reversal of rocuronium-induced neuromuscular block by sugammadex is independent of renal perfusion in anesthetized cats

Sugammadex reverses neuromuscular block induced by 3-desacetyl-vecuronium, an active metabolite of vecuronium, in the anaesthetised rhesus monkey

Reversal of Neuromusclar Blockade and Simultaneous Increase in Plasma Rocuronium Concentration after the Intravenous Infusion of the Novel Reversal Agent Org 25970

Reversal of neuromuscular blockade and simultaneous increase in plasma Rocuronium concentration after the intravenous infusion of the novel reversal agent Org 25969

A novel concept of reversing neuromuscular block: chemical encapsulation of rocuronium bromide by a cyclodextrin-based synthetic host

A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host

Reversal of profound rocuronium neuromuscular blockade by sugammadex in anesthetized rhesus monkeys

Selective relaxant binding agents for reversal of neuromuscular blockade

(1)-2 The discovery and preclinical development of sugammadex

Synthesis and evaluation of N-3 substituted phenoxypropyl piperidine benzimidazol-2-one analogues as NOP receptor agonists with analgesic and sedative properties

Org 25969 Causes Rapid Reversal of Rocuronium-Induced Neuromuscular Block, Independent of Acid-Base Status: 2002[A-1009

2- O-Substituted Cyclodextrins as Reversal Agents for the Neuromuscular Blocker Rocuronium Bromide

A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host

Parallel solid-phase synthesis of zatebradine analogues as potential If channel blockers

Effects of 5-Hydroxytryptamine on Capillary and Arteriovenous Anastomotic Blood Flow in the Human Hand and Forearm and in the Pig Hind Leg

Parallel solid-Phase synthesis of zatebradine analogues as potential I f channel blockers

Carotid haemodynamics in pigs during infusions of 8‐O‐DPAT: reduction in arteriovenous shunting is mediated by 5‐HT1‐like receptors

Constriction of porcine arteriovenous anastomoses by indorenate is unrelated to 5-HT1A, 5-HT1B, 5-HT1C or 5-HT1D receptor

Carotid haemodynamics in pigs during infusions of 8‐O‐DPAT: reduction in arteriovenous shunting is mediated by 5‐HT 1 ‐like receptors

Characterization of 5-hydroxytryptamine receptors in the cranial vasculature

Characterization of 5-Hydroxytryptamine Receptors in the Cranial Vasculature

Reduction of cephalic arteriovenous shunting by ergotamine is not mediated by 5‐HT1‐like or 5‐HT2 receptors

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