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Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance

Nature communications, 2022-06, Vol.13 (1), p.3556-3556, Article 3556

2022

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Experimental illumination of a fitness landscape

Proceedings of the National Academy of Sciences - PNAS, 2011-05, Vol.108 (19), p.7896-7901

2011

Volltextzugriff (PDF)

A systematic survey of an intragenic epistatic landscape

Molecular biology and evolution, 2015-01, Vol.32 (1), p.229-238

2015

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Fitness analyses of all possible point mutations for regions of genes in yeast

Nature protocols, 2012-07, Vol.7 (7), p.1382-1396

2012

Volltextzugriff (PDF)

Quantifying and understanding the fitness effects of protein mutations: Laboratory versus nature

Protein science, 2016-07, Vol.25 (7), p.1219-1226

2016

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A bayesian MCMC approach to assess the complete distribution of fitness effects of new mutations: uncovering the potential for adaptive walks in challenging environments

Genetics (Austin), 2014-03, Vol.196 (3), p.841-852

2014

Volltextzugriff (PDF)

Influenza virus drug resistance: a time-sampled population genetics perspective

PLoS genetics, 2014-02, Vol.10 (2), p.e1004185-e1004185

2014

Volltextzugriff (PDF)

Identification of a Permissive Secondary Mutation That Restores the Enzymatic Activity of Oseltamivir Resistance Mutation H275Y

Journal of virology, 2022-03, Vol.96 (6), p.e0198221-e0198221

2022

Volltextzugriff (PDF)

Systematic exploration of ubiquitin sequence, E1 activation efficiency, and experimental fitness in yeast

Journal of molecular biology, 2014-07, Vol.426 (15), p.2854-2870

2014

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Hydrophobic Core Flexibility Modulates Enzyme Activity in HIV-1 Protease

Journal of the American Chemical Society, 2012-03, Vol.134 (9), p.4163-4168

2012

Volltextzugriff (PDF)

Molecular Determinants of Epistasis in HIV‑1 Protease: Elucidating the Interdependence of L89V and L90M Mutations in Resistance

Biochemistry (Easton), 2019-09, Vol.58 (35), p.3711-3726

2019

Volltextzugriff (PDF)

Latent effects of Hsp90 mutants revealed at reduced expression levels

PLoS genetics, 2013-06, Vol.9 (6), p.e1003600

2013

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Enzyme-like Proteins by Computational Design

Proceedings of the National Academy of Sciences - PNAS, 2001-12, Vol.98 (25), p.14274-14279

2001

Volltextzugriff (PDF)

An experimental evaluation of drug-induced mutational meltdown as an antiviral treatment strategy

Evolution, 2016-11, Vol.70 (11), p.2470-2484

2016

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A Balance between Inhibitor Binding and Substrate Processing Confers Influenza Drug Resistance

Journal of molecular biology, 2016-02, Vol.428 (3), p.538-553

2016

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Evolution of the Influenza A Virus Genome during Development of Oseltamivir Resistance In Vitro

Journal of Virology, 2014-01, Vol.88 (1), p.272-281

2014

Volltextzugriff (PDF)

Analyses of the Effects of All Ubiquitin Point Mutants on Yeast Growth Rate

Journal of molecular biology, 2013-04, Vol.425 (8), p.1363-1377

2013

Volltextzugriff (PDF)

Specificity versus Stability in Computational Protein Design

Proceedings of the National Academy of Sciences - PNAS, 2005-09, Vol.102 (36), p.12724-12729

2005

Volltextzugriff (PDF)

Pervasive contingency and entrenchment in a billion years of Hsp90 evolution

Proceedings of the National Academy of Sciences - PNAS, 2018-04, Vol.115 (17), p.4453-4458

2018

Volltextzugriff (PDF)

Mutational fitness landscape and drug resistance

Current opinion in structural biology, 2023-02, Vol.78, p.102525-102525, Article 102525

2023

Volltextzugriff (PDF)

Solubility-Promoting Function of Hsp90 Contributes to Client Maturation and Robust Cell Growth

Eukaryotic Cell, 2012-08, Vol.11 (8), p.1033-1041

2012

Volltextzugriff (PDF)

Designed Hsp90 Heterodimers Reveal an Asymmetric ATPase-Driven Mechanism In Vivo

Molecular cell, 2014-01, Vol.53 (2), p.344-350

2014

Volltextzugriff (PDF)

Sequence dependencies and biophysical features both govern cleavage of diverse cut‐sites by HIV protease

Protein science, 2022-07, Vol.31 (7), p.e4366-n/a

2022

Volltextzugriff (PDF)

SHIFTING FITNESS LANDSCAPES IN RESPONSE TO ALTERED ENVIRONMENTS

Evolution, 2013-12, Vol.67 (12), p.3512-3522

2013

Volltextzugriff (PDF)

The Adaptive Potential of the Middle Domain of Yeast Hsp90

Molecular biology and evolution, 2021-02, Vol.38 (2), p.368-379

2021

Volltextzugriff (PDF)

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Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance

Experimental illumination of a fitness landscape

A systematic survey of an intragenic epistatic landscape

Fitness analyses of all possible point mutations for regions of genes in yeast

Quantifying and understanding the fitness effects of protein mutations: Laboratory versus nature

A bayesian MCMC approach to assess the complete distribution of fitness effects of new mutations: uncovering the potential for adaptive walks in challenging environments

Influenza virus drug resistance: a time-sampled population genetics perspective

Identification of a Permissive Secondary Mutation That Restores the Enzymatic Activity of Oseltamivir Resistance Mutation H275Y

Systematic exploration of ubiquitin sequence, E1 activation efficiency, and experimental fitness in yeast

Hydrophobic Core Flexibility Modulates Enzyme Activity in HIV-1 Protease

Molecular Determinants of Epistasis in HIV‑1 Protease: Elucidating the Interdependence of L89V and L90M Mutations in Resistance

Latent effects of Hsp90 mutants revealed at reduced expression levels

Enzyme-like Proteins by Computational Design

An experimental evaluation of drug-induced mutational meltdown as an antiviral treatment strategy

A Balance between Inhibitor Binding and Substrate Processing Confers Influenza Drug Resistance

Evolution of the Influenza A Virus Genome during Development of Oseltamivir Resistance In Vitro

Analyses of the Effects of All Ubiquitin Point Mutants on Yeast Growth Rate

Specificity versus Stability in Computational Protein Design

Pervasive contingency and entrenchment in a billion years of Hsp90 evolution

Mutational fitness landscape and drug resistance

Solubility-Promoting Function of Hsp90 Contributes to Client Maturation and Robust Cell Growth

Designed Hsp90 Heterodimers Reveal an Asymmetric ATPase-Driven Mechanism In Vivo

Sequence dependencies and biophysical features both govern cleavage of diverse cut‐sites by HIV protease

SHIFTING FITNESS LANDSCAPES IN RESPONSE TO ALTERED ENVIRONMENTS

The Adaptive Potential of the Middle Domain of Yeast Hsp90

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