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Systematic Mutant Analyses Elucidate General and Client-Specific Aspects of Hsp90 Function

Cell reports (Cambridge), 2016-04, Vol.15 (3), p.588-598

2016

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Experimental illumination of a fitness landscape

Proceedings of the National Academy of Sciences - PNAS, 2011-05, Vol.108 (19), p.7896-7901

2011

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Analyses of the Effects of All Ubiquitin Point Mutants on Yeast Growth Rate

Journal of molecular biology, 2013-04, Vol.425 (8), p.1363-1377

2013

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Designed Hsp90 Heterodimers Reveal an Asymmetric ATPase-Driven Mechanism In Vivo

Molecular cell, 2014-01, Vol.53 (2), p.344-350

2014

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The Adaptive Potential of the Middle Domain of Yeast Hsp90

Molecular biology and evolution, 2021-02, Vol.38 (2), p.368-379

2021

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Systematic exploration of ubiquitin sequence, E1 activation efficiency, and experimental fitness in yeast

Journal of molecular biology, 2014-07, Vol.426 (15), p.2854-2870

2014

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Systematic profiling of dominant ubiquitin variants reveals key functional nodes contributing to evolutionary selection

Cell reports (Cambridge), 2023-09, Vol.42 (9), p.113064-113064, Article 113064

2023

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Fitness analyses of all possible point mutations for regions of genes in yeast

Nature protocols, 2012-07, Vol.7 (7), p.1382-1396

2012

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Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV‑1 Protease in Conferring Drug Resistance

ACS chemical biology, 2019-11, Vol.14 (11), p.2441-2452

2019

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Latent effects of Hsp90 mutants revealed at reduced expression levels

PLoS genetics, 2013-06, Vol.9 (6), p.e1003600

2013

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Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance

Nature communications, 2022-06, Vol.13 (1), p.3556-3556, Article 3556

2022

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Mutational fitness landscape and drug resistance

Current opinion in structural biology, 2023-02, Vol.78, p.102525-102525, Article 102525

2023

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Pervasive contingency and entrenchment in a billion years of Hsp90 evolution

Proceedings of the National Academy of Sciences - PNAS, 2018-04, Vol.115 (17), p.4453-4458

2018

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A systematic survey of an intragenic epistatic landscape

Molecular biology and evolution, 2015-01, Vol.32 (1), p.229-238

2015

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Sequence dependencies and biophysical features both govern cleavage of diverse cut‐sites by HIV protease

Protein science, 2022-07, Vol.31 (7), p.e4366-n/a

2022

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Quantifying and understanding the fitness effects of protein mutations: Laboratory versus nature

Protein science, 2016-07, Vol.25 (7), p.1219-1226

2016

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Mutational fitness landscape and resistance

Current opinion in structural biology, 2023-01, Vol.78, p.102525-102525

2023

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SHIFTING FITNESS LANDSCAPES IN RESPONSE TO ALTERED ENVIRONMENTS

Evolution, 2013-12, Vol.67 (12), p.3512-3522

2013

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Comprehensive fitness maps of Hsp90 show widespread environmental dependence

eLife, 2020-03, Vol.9

2020

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Mechanistic Asymmetry in Hsp90 Dimers

Journal of molecular biology, 2015-09, Vol.427 (18), p.2904-2911

2015

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Quantitative structural analysis of influenza virus by cryo-electron tomography and convolutional neural networks

Structure (London), 2022-05, Vol.30 (5), p.777-786.e3

2022

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Identification of a Permissive Secondary Mutation That Restores the Enzymatic Activity of Oseltamivir Resistance Mutation H275Y

Journal of virology, 2022-03, Vol.96 (6), p.e0198221-e0198221

2022

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Mutations in Influenza A Virus Neuraminidase and Hemagglutinin Confer Resistance against a Broadly Neutralizing Hemagglutinin Stem Antibody

Journal of virology, 2019-01, Vol.93 (2)

2019

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An experimental evaluation of drug-induced mutational meltdown as an antiviral treatment strategy

Evolution, 2016-11, Vol.70 (11), p.2470-2484

2016

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Molecular Determinants of Epistasis in HIV‑1 Protease: Elucidating the Interdependence of L89V and L90M Mutations in Resistance

Biochemistry (Easton), 2019-09, Vol.58 (35), p.3711-3726

2019

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Systematic Mutant Analyses Elucidate General and Client-Specific Aspects of Hsp90 Function

Experimental illumination of a fitness landscape

Analyses of the Effects of All Ubiquitin Point Mutants on Yeast Growth Rate

Designed Hsp90 Heterodimers Reveal an Asymmetric ATPase-Driven Mechanism In Vivo

The Adaptive Potential of the Middle Domain of Yeast Hsp90

Systematic exploration of ubiquitin sequence, E1 activation efficiency, and experimental fitness in yeast

Systematic profiling of dominant ubiquitin variants reveals key functional nodes contributing to evolutionary selection

Fitness analyses of all possible point mutations for regions of genes in yeast

Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV‑1 Protease in Conferring Drug Resistance

Latent effects of Hsp90 mutants revealed at reduced expression levels

Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance

Mutational fitness landscape and drug resistance

Pervasive contingency and entrenchment in a billion years of Hsp90 evolution

A systematic survey of an intragenic epistatic landscape

Sequence dependencies and biophysical features both govern cleavage of diverse cut‐sites by HIV protease

Quantifying and understanding the fitness effects of protein mutations: Laboratory versus nature

Mutational fitness landscape and resistance

SHIFTING FITNESS LANDSCAPES IN RESPONSE TO ALTERED ENVIRONMENTS

Comprehensive fitness maps of Hsp90 show widespread environmental dependence

Mechanistic Asymmetry in Hsp90 Dimers

Quantitative structural analysis of influenza virus by cryo-electron tomography and convolutional neural networks

Identification of a Permissive Secondary Mutation That Restores the Enzymatic Activity of Oseltamivir Resistance Mutation H275Y

Mutations in Influenza A Virus Neuraminidase and Hemagglutinin Confer Resistance against a Broadly Neutralizing Hemagglutinin Stem Antibody

An experimental evaluation of drug-induced mutational meltdown as an antiviral treatment strategy

Molecular Determinants of Epistasis in HIV‑1 Protease: Elucidating the Interdependence of L89V and L90M Mutations in Resistance

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