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Polypharmacology in a single drug: multitarget drugs

Current medicinal chemistry, 2013-04, Vol.20 (13), p.1639-1645

Bolognesi, M L

2013

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Molecular Hybridization as a Tool for Designing Multitarget Drug Candidates for Complex Diseases

Current topics in medicinal chemistry, 2019-01, Vol.19 (19), p.1694-1711

2019

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From combinations to multitarget‐directed ligands: A continuum in Alzheimer's disease polypharmacology

Medicinal research reviews, 2021-09, Vol.41 (5), p.2606-2633

2021

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Stereocontrolled transformations of cyclohexadienone derivatives to access stereochemically rich and natural product-inspired architectures

Organic & biomolecular chemistry, 2020-11, Vol.18 (42), p.8526-8571

2020

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Tacrine derivatives and Alzheimer's disease

Current medicinal chemistry, 2010-06, Vol.17 (17), p.1825-1838

2010

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Rational Approach To Discover Multipotent Anti-Alzheimer Drugs

Journal of medicinal chemistry, 2005-01, Vol.48 (2), p.360-363

2005

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Two diseases, one approach: multitarget drug discovery in Alzheimer's and neglected tropical diseases

MedChemComm, 2014-01, Vol.5 (7), p.853-861

2014

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Nutritional and Pharmacological Strategies to Regulate Microglial Polarization in Cognitive Aging and Alzheimer's Disease

Frontiers in aging neuroscience, 2017-06, Vol.9, p.175-175

2017

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Presynaptic M3 muscarinic cholinoceptors mediate inhibition of excitatory synaptic transmission in area CA1 of rat hippocampus

Brain research, 2015-12, Vol.1629, p.260-269

2015

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The Mu.Ta.Lig. Chemotheca: A Community-Populated Molecular Database for Multi-Target Ligands Identification and Compound-Repurposing

Frontiers in chemistry, 2018-04, Vol.6, p.130-130

2018

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Alzheimer's disease: new approaches to drug discovery

Current opinion in chemical biology, 2009-06, Vol.13 (3), p.303-308

2009

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Cardiovascular disease prevention at the workplace: assessing the prognostic value of lifestyle risk factors and job-related conditions

International journal of public health, 2018-07, Vol.63 (6), p.723-732

2018

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Histone deacetylases as targets for the treatment of neurodegenerative disorders: Challenges and future opportunities

Medicinal research reviews, 2020-11, Vol.40 (6), p.2177-2211

2020

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New tacrine dimers with antioxidant linkers as dual drugs: Anti-Alzheimer's and antiproliferative agents

European journal of medicinal chemistry, 2017-09, Vol.138, p.761-773

2017

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Inhibition of Acetylcholinesterase, β-Amyloid Aggregation, and NMDA Receptors in Alzheimer’s Disease: A Promising Direction for the Multi-target-Directed Ligands Gold Rush

Journal of medicinal chemistry, 2008-08, Vol.51 (15), p.4381-4384

2008

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Targeting Lewy body dementia with neflamapimod‐rasagiline hybrids

Archiv der Pharmazie (Weinheim), 2024-06, Vol.357 (6), p.e2300525-n/a

2024

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Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer's disease: Selective subnanomolar BuChE inhibitors

European journal of medicinal chemistry, 2019-11, Vol.181, p.111550, Article 111550

2019

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Cystamine-tacrine dimer: A new multi-target-directed ligand as potential therapeutic agent for Alzheimer’s disease treatment

Neuropharmacology, 2012-02, Vol.62 (2), p.997-1003

2012

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Sequential Virtual Screening Approach to the Identification of Small Organic Molecules as Potential BACE-1 Inhibitors

Chemical biology & drug design, 2011-04, Vol.77 (4), p.268-271

2011

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MTDL design strategy in the context of Alzheimer's disease: from lipocrine to memoquin and beyond

Current pharmaceutical design, 2009-02, Vol.15 (6), p.601-613

2009

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Prejunctional muscarinic inhibitory control of acetylcholine release in the human isolated detrusor: involvement of the M4 receptor subtype

British journal of pharmacology, 2000-02, Vol.129 (3), p.493-500

2000

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Acetylcholinesterase Noncovalent Inhibitors Based on a Polyamine Backbone for Potential Use against Alzheimer's Disease

Journal of medicinal chemistry, 1998-10, Vol.41 (22), p.4186-4189

1998

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3,4-Dihydro-1,3,5-triazin-2(1H)‑ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer’s Disease

ACS chemical neuroscience, 2015-10, Vol.6 (10), p.1665-1682

2015

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Propidium-Based Polyamine Ligands as Potent Inhibitors of Acetylcholinesterase and Acetylcholinesterase-Induced Amyloid-β Aggregation

Journal of medicinal chemistry, 2005-01, Vol.48 (1), p.24-27

2005

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Earthquake-induced variations in the composition of the water in the geothermal reservoir at Vulcano Island, Italy

Journal of volcanology and geothermal research, 2000-06, Vol.99 (1), p.139-150

Bolognesi, L.

2000

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Polypharmacology in a single drug: multitarget drugs

Molecular Hybridization as a Tool for Designing Multitarget Drug Candidates for Complex Diseases

From combinations to multitarget‐directed ligands: A continuum in Alzheimer's disease polypharmacology

Stereocontrolled transformations of cyclohexadienone derivatives to access stereochemically rich and natural product-inspired architectures

Tacrine derivatives and Alzheimer's disease

Rational Approach To Discover Multipotent Anti-Alzheimer Drugs

Two diseases, one approach: multitarget drug discovery in Alzheimer's and neglected tropical diseases

Nutritional and Pharmacological Strategies to Regulate Microglial Polarization in Cognitive Aging and Alzheimer's Disease

Presynaptic M3 muscarinic cholinoceptors mediate inhibition of excitatory synaptic transmission in area CA1 of rat hippocampus

The Mu.Ta.Lig. Chemotheca: A Community-Populated Molecular Database for Multi-Target Ligands Identification and Compound-Repurposing

Alzheimer's disease: new approaches to drug discovery

Cardiovascular disease prevention at the workplace: assessing the prognostic value of lifestyle risk factors and job-related conditions

Histone deacetylases as targets for the treatment of neurodegenerative disorders: Challenges and future opportunities

New tacrine dimers with antioxidant linkers as dual drugs: Anti-Alzheimer's and antiproliferative agents

Inhibition of Acetylcholinesterase, β-Amyloid Aggregation, and NMDA Receptors in Alzheimer’s Disease: A Promising Direction for the Multi-target-Directed Ligands Gold Rush

Targeting Lewy body dementia with neflamapimod‐rasagiline hybrids

Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer's disease: Selective subnanomolar BuChE inhibitors

Cystamine-tacrine dimer: A new multi-target-directed ligand as potential therapeutic agent for Alzheimer’s disease treatment

Sequential Virtual Screening Approach to the Identification of Small Organic Molecules as Potential BACE-1 Inhibitors

MTDL design strategy in the context of Alzheimer's disease: from lipocrine to memoquin and beyond

Prejunctional muscarinic inhibitory control of acetylcholine release in the human isolated detrusor: involvement of the M4 receptor subtype

Acetylcholinesterase Noncovalent Inhibitors Based on a Polyamine Backbone for Potential Use against Alzheimer's Disease

3,4-Dihydro-1,3,5-triazin-2(1H)‑ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer’s Disease

Propidium-Based Polyamine Ligands as Potent Inhibitors of Acetylcholinesterase and Acetylcholinesterase-Induced Amyloid-β Aggregation

Earthquake-induced variations in the composition of the water in the geothermal reservoir at Vulcano Island, Italy

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