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Therapeutic Targets and Precision Medicine in COPD: Inflammation, Ion Channels, Both, or Neither?

International journal of molecular sciences, 2023-12, Vol.24 (24), p.17363

Bolger, Graeme B

2023

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The cAMP-signaling cancers: Clinically-divergent disorders with a common central pathway

Frontiers in endocrinology (Lausanne), 2022-10, Vol.13, p.1024423-1024423

Bolger, Graeme B.

2022

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The PDE-Opathies: Diverse Phenotypes Produced by a Functionally Related Multigene Family

Trends in genetics, 2021-07, Vol.37 (7), p.669-681

Bolger, Graeme B.

2021

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Dominant-Negative Attenuation of cAMP-Selective Phosphodiesterase PDE4D Action Affects Learning and Behavior

International journal of molecular sciences, 2020-08, Vol.21 (16), p.5704

2020

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Altered phosphorylation, electrophysiology, and behavior on attenuation of PDE4B action in hippocampus

BMC neuroscience, 2017-12, Vol.18 (1), p.77-77, Article 77

2017

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Cystic fibrosis transmembrane conductance regulator activation by roflumilast contributes to therapeutic benefit in chronic bronchitis

American journal of respiratory cell and molecular biology, 2014-03, Vol.50 (3), p.549-558

2014

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The RACK1 scaffold protein: a dynamic cog in cell response mechanisms

Molecular pharmacology, 2002-12, Vol.62 (6), p.1261-1273

2002

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Isoform-Selective Susceptibility of DISC1/Phosphodiesterase-4 Complexes to Dissociation by Elevated Intracellular cAMP Levels

The Journal of neuroscience, 2007-08, Vol.27 (35), p.9513-9524

2007

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The RNA-binding protein SERBP1 interacts selectively with the signaling protein RACK1

Cellular signalling, 2017-07, Vol.35, p.256-263

Bolger, Graeme B.

2017

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Reduced protein expression of the phosphodiesterases PDE4A4 and PDE4A8 in AIP mutation positive somatotroph adenomas

Molecular and cellular endocrinology, 2018-11, Vol.476, p.103-109

2018

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Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5

Biochemical journal, 2006-08, Vol.398 (1), p.23-36

2006

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Phosphodiesterases and cAMP Pathway in Pituitary Diseases

Frontiers in endocrinology (Lausanne), 2019-03, Vol.10, p.141-141

2019

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RACK1 and β-arrestin2 attenuate dimerization of PDE4 cAMP phosphodiesterase PDE4D5

Cellular signalling, 2016-07, Vol.28 (7), p.706-712

Bolger, Graeme B.

2016

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Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N- and C-domains of beta-arrestin using spot-immobilized peptide arrays

Biochemical journal, 2007-05, Vol.404 (1), p.71-80

2007

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The PDE4 cAMP-Specific Phosphodiesterases: Targets for Drugs with Antidepressant and Memory-Enhancing Action

Advances in neurobiology, 2017, Vol.17, p.63-102

2017

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Attenuation of the Activity of the cAMP-specific Phosphodiesterase PDE4A5 by Interaction with the Immunophilin XAP2

The Journal of biological chemistry, 2003-08, Vol.278 (35), p.33351-33363

2003

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Differential expression and regulation of the cAMP-selective phosphodiesterase type 4A splice variants in rat brain by chronic antidepressant administration

The European journal of neuroscience, 2005-09, Vol.22 (6), p.1463-1475

2005

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Testicular Cancer, Version 2.2015

Journal of the National Comprehensive Cancer Network, 2015-06, Vol.13 (6), p.772-799

2015

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Human PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary change

Biochemical journal, 2008-04, Vol.411 (2), p.361-369

2008

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Characterization of aryl hydrocarbon receptor interacting protein (AIP) mutations in familial isolated pituitary adenoma families

Human mutation, 2010-08, Vol.31 (8), p.950-960

2010

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Characterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene

Biochemical journal, 1997-12, Vol.328 ( Pt 2) (2), p.539-548

1997

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The Role of the Aryl Hydrocarbon Receptor-Interacting Protein Gene in Familial and Sporadic Pituitary Adenomas

The journal of clinical endocrinology and metabolism, 2008-06, Vol.93 (6), p.2390-2401

2008

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cAMP-specific PDE4 phosphodiesterases and AIP in the pathogenesis of pituitary tumors

Endocrine-related cancer, 2016-05, Vol.23 (5), p.419-431

2016

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Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains

Cellular signalling, 2015-04, Vol.27 (4), p.756-769

2015

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Molecular cloning and subcellular distribution of the novel PDE4B4 cAMP-specific phosphodiesterase isoform

Biochemical journal, 2003-03, Vol.370 (Pt 2), p.429-438

2003

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Therapeutic Targets and Precision Medicine in COPD: Inflammation, Ion Channels, Both, or Neither?

The cAMP-signaling cancers: Clinically-divergent disorders with a common central pathway

The PDE-Opathies: Diverse Phenotypes Produced by a Functionally Related Multigene Family

Dominant-Negative Attenuation of cAMP-Selective Phosphodiesterase PDE4D Action Affects Learning and Behavior

Altered phosphorylation, electrophysiology, and behavior on attenuation of PDE4B action in hippocampus

Cystic fibrosis transmembrane conductance regulator activation by roflumilast contributes to therapeutic benefit in chronic bronchitis

The RACK1 scaffold protein: a dynamic cog in cell response mechanisms

Isoform-Selective Susceptibility of DISC1/Phosphodiesterase-4 Complexes to Dissociation by Elevated Intracellular cAMP Levels

The RNA-binding protein SERBP1 interacts selectively with the signaling protein RACK1

Reduced protein expression of the phosphodiesterases PDE4A4 and PDE4A8 in AIP mutation positive somatotroph adenomas

Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5

Phosphodiesterases and cAMP Pathway in Pituitary Diseases

RACK1 and β-arrestin2 attenuate dimerization of PDE4 cAMP phosphodiesterase PDE4D5

Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N- and C-domains of beta-arrestin using spot-immobilized peptide arrays

The PDE4 cAMP-Specific Phosphodiesterases: Targets for Drugs with Antidepressant and Memory-Enhancing Action

Attenuation of the Activity of the cAMP-specific Phosphodiesterase PDE4A5 by Interaction with the Immunophilin XAP2

Differential expression and regulation of the cAMP-selective phosphodiesterase type 4A splice variants in rat brain by chronic antidepressant administration

Testicular Cancer, Version 2.2015

Human PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary change

Characterization of aryl hydrocarbon receptor interacting protein (AIP) mutations in familial isolated pituitary adenoma families

Characterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene

The Role of the Aryl Hydrocarbon Receptor-Interacting Protein Gene in Familial and Sporadic Pituitary Adenomas

cAMP-specific PDE4 phosphodiesterases and AIP in the pathogenesis of pituitary tumors

Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains

Molecular cloning and subcellular distribution of the novel PDE4B4 cAMP-specific phosphodiesterase isoform

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