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Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance

Nature communications, 2016-04, Vol.7 (1), p.11384-11384, Article 11384

2016

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Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A

Nature chemical biology, 2017-07, Vol.13 (7), p.785

2017

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Phosphorylation of SAMHD1 Thr592 increases C-terminal domain dynamics, tetramer dissociation and ssDNA binding kinetics

Nucleic acids research, 2022-07, Vol.50 (13), p.7545

2022

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The Axl kinase domain in complex with a macrocyclic inhibitor offers first structural insights into an active TAM receptor kinase

The Journal of biological chemistry, 2017-09, Vol.292 (38), p.15705-15716

2017

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Development of a Potential High-Throughput Workflow to Characterize Sites of Bioconjugation by Immuno-Affinity Capture Coupled to MALDI-TOF Mass Spectrometry

Bioconjugate chemistry, 2013-01, Vol.24 (1), p.53-62

2013

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Enzyme kinetics and distinct modulation of the protein kinase N family of kinases by lipid activators and small molecule inhibitors

Bioscience reports, 2014-04, Vol.34 (2), p.e00097

2014

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Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1

The Journal of biological chemistry, 2021-01, Vol.296, p.100251, Article 100251

2021

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Covalent EGFR inhibitor analysis reveals importance of reversible interactions to potency and mechanisms of drug resistance

Proceedings of the National Academy of Sciences - PNAS, 2014-01, Vol.111 (1), p.173-178

2014

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Structural and Biophysical Characterization of XIAP BIR3 G306E Mutant: Insights in Protein Dynamics and Application for Fragment-Based Drug Design

Chemical biology & drug design, 2009-09, Vol.74 (3), p.212-223

2009

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Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2

eLife, 2017-11, Vol.6

2017

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Reviving B‑Factors: Activating ALK Mutations Increase Protein Dynamics of the Unphosphorylated Kinase

ACS medicinal chemistry letters, 2018-09, Vol.9 (9), p.872-877

2018

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Abstract 4456: Biochemical and structural characteristics of crizotinib-resistant ALK mutants

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.4456-4456

2013

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Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants

The Journal of biological chemistry, 2022-06, Vol.298 (6), p.101972-101972, Article 101972

2022

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Supercritical Fluid Chromatography Reduction of Hydrogen/Deuterium Back Exchange in Solution-Phase Hydrogen/Deuterium Exchange with Mass Spectrometric Analysis

Analytical chemistry (Washington), 2006-10, Vol.78 (19), p.7058-7060

2006

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SFC/MS in drug discovery at Pfizer, La Jolla

International journal of mass spectrometry, 2004-11, Vol.238 (2), p.85-97

2004

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Abstract 330: Engineering electrophile-sensitive kinase mutants to accelerate oncology target validation

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.330-330

2021

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Reviving B-Factors: Activating ALK Mutations Increase Protein Dynamics of the Unphosphorylated Kinase

ACS medicinal chemistry letters, 2019-08, Vol.9 (9)

2019

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Fourier transform ion cyclotron resonance mass spectrometry using atmospheric pressure photoionization for high-resolution analyses of corticosteroids

Rapid communications in mass spectrometry, 2003-01, Vol.17 (24), p.2763-2768

2003

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Preserving the Chromatographic Integrity of High-Speed Supercritical Fluid Chromatography Separations Using Time-of-Flight Mass Spectrometry

Journal of combinatorial chemistry, 2003-07, Vol.5 (4), p.451-455

2003

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Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1

The Journal of biological chemistry, 2021-01, p.100251

2021

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Development of a long acting human growth hormone analog suitable for once a week dosing

Bioorganic & medicinal chemistry letters, 2013-01, Vol.23 (2), p.402-406

2013

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Mass spectrometry in high throughput analysis

Journal of spectroscopy (Hindawi), 2003-01, Vol.17 (4), p.663-680

2003

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Seasonal mixed layer depth shapes phytoplankton physiology, viral production, and accumulation in the North Atlantic

Nature communications, 2021-11, Vol.12 (1), p.6634-6634, Article 6634

2021

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Efficient dilution-to-extinction isolation of novel virus-host model systems for fastidious heterotrophic bacteria

The ISME Journal, 2021-06, Vol.15 (6), p.1585-1598

2021

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Influence of host phylogeny and water physicochemistry on microbial assemblages of the fish skin microbiome

FEMS microbiology ecology, 2024-02, Vol.100 (3)

2024

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Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance

Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A

Phosphorylation of SAMHD1 Thr592 increases C-terminal domain dynamics, tetramer dissociation and ssDNA binding kinetics

The Axl kinase domain in complex with a macrocyclic inhibitor offers first structural insights into an active TAM receptor kinase

Development of a Potential High-Throughput Workflow to Characterize Sites of Bioconjugation by Immuno-Affinity Capture Coupled to MALDI-TOF Mass Spectrometry

Enzyme kinetics and distinct modulation of the protein kinase N family of kinases by lipid activators and small molecule inhibitors

Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1

Covalent EGFR inhibitor analysis reveals importance of reversible interactions to potency and mechanisms of drug resistance

Structural and Biophysical Characterization of XIAP BIR3 G306E Mutant: Insights in Protein Dynamics and Application for Fragment-Based Drug Design

Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2

Reviving B‑Factors: Activating ALK Mutations Increase Protein Dynamics of the Unphosphorylated Kinase

Abstract 4456: Biochemical and structural characteristics of crizotinib-resistant ALK mutants

Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants

Supercritical Fluid Chromatography Reduction of Hydrogen/Deuterium Back Exchange in Solution-Phase Hydrogen/Deuterium Exchange with Mass Spectrometric Analysis

SFC/MS in drug discovery at Pfizer, La Jolla

Abstract 330: Engineering electrophile-sensitive kinase mutants to accelerate oncology target validation

Reviving B-Factors: Activating ALK Mutations Increase Protein Dynamics of the Unphosphorylated Kinase

Fourier transform ion cyclotron resonance mass spectrometry using atmospheric pressure photoionization for high-resolution analyses of corticosteroids

Preserving the Chromatographic Integrity of High-Speed Supercritical Fluid Chromatography Separations Using Time-of-Flight Mass Spectrometry

Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1

Development of a long acting human growth hormone analog suitable for once a week dosing

Mass spectrometry in high throughput analysis

Seasonal mixed layer depth shapes phytoplankton physiology, viral production, and accumulation in the North Atlantic

Efficient dilution-to-extinction isolation of novel virus-host model systems for fastidious heterotrophic bacteria

Influence of host phylogeny and water physicochemistry on microbial assemblages of the fish skin microbiome

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