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Reappraisal of metformin efficacy in the treatment of type 2 diabetes: a meta-analysis of randomised controlled trials

PLoS medicine, 2012-04, Vol.9 (4), p.e1001204

2012

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Using numerical modeling and simulation to assess the ethical burden in clinical trials and how it relates to the proportion of responders in a trial sample

PloS one, 2021-10, Vol.16 (10), p.e0258093-e0258093

2021

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Modeling the disruption of respiratory disease clinical trials by non-pharmaceutical COVID-19 interventions

Nature communications, 2022-04, Vol.13 (1), p.1980-1980, Article 1980

2022

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Empirical methods for the validation of time-to-event mathematical models taking into account uncertainty and variability: application to EGFR + lung adenocarcinoma

BMC bioinformatics, 2023-09, Vol.24 (1), p.1-331, Article 331

2023

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Scientific and regulatory evaluation of mechanistic in silico drug and disease models in drug development: Building model credibility

CPT: pharmacometrics and systems pharmacology, 2021-08, Vol.10 (8), p.804-825

2021

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Verifying and Validating Quantitative Systems Pharmacology and In Silico Models in Drug Development: Current Needs, Gaps, and Challenges

CPT: pharmacometrics and systems pharmacology, 2020-04, Vol.9 (4), p.195-197

2020

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Risks of untreated and treated isolated systolic hypertension in the elderly: meta-analysis of outcome trials

The Lancet (British edition), 2000-03, Vol.355 (9207), p.865-872

2000

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High Risk versus Proportional Benefit: Modelling Equitable Strategies in Cardiovascular Prevention

PloS one, 2015-11, Vol.10 (11), p.e0140793-e0140793

2015

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From Clinical Trial Efficacy to Real-Life Effectiveness: Why Conventional Metrics do not Work

Drugs -- real world outcomes, 2019-09, Vol.6 (3), p.125-132

2019

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Solving the Evidence Interpretability Crisis in Health Technology Assessment: A Role for Mechanistic Models?

Frontiers in medical technology, 2022-02, Vol.4, p.810315

2022

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Chronic Lung Allograft Dysfunction: A Systematic Review of Mechanisms

Transplantation, 2016-09, Vol.100 (9), p.1803

2016

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A systematic review of the accuracy of ultrasound in the diagnosis of deep venous thrombosis in asymptomatic patients

Thrombosis and haemostasis, 2004-04, Vol.91 (4), p.655

2004

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The global risk approach should be better applied in French hypertensive patients: a comparison between simulation and observation studies

PloS one, 2011-03, Vol.6 (3), p.e17508-e17508

2011

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Pulsatile blood pressure component as predictor of mortality in hypertension: a meta-analysis of clinical trial control groups

Journal of hypertension, 2002-01, Vol.20 (1), p.145-151

2002

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An in silico target identification using Boolean network attractors: Avoiding pathological phenotypes

Comptes rendus. Biologies, 2014-12, Vol.337 (12), p.661-678

2014

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Low protein diets delay end‐stage renal disease in non‐diabetic adults with chronic renal failure

Nephrology, dialysis, transplantation, 2000-12, Vol.15 (12), p.1986-1992

2000

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Effect model law: an approach for the implementation of personalized medicine

Journal of Personalized Medicine, 2013-08, Vol.3 (3), p.177-190

2013

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Clinical effects of β-adrenergic blockade in chronic heart failure : A meta-analysis of double-blind, placebo-controlled, randomized trials

Circulation (New York, N.Y.), 1998-09, Vol.98 (12), p.1184-1191

1998

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A pharmacologically based multiscale mathematical model of angiogenesis and its use in investigating the efficacy of a new cancer treatment strategy

Journal of theoretical biology, 2009-10, Vol.260 (4), p.545-562

2009

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Comparison of 3 and 6 months of oral anticoagulant therapy after a first episode of proximal deep vein thrombosis or pulmonary embolism and comparison of 6 and 12 weeks of therapy after isolated calf deep vein thrombosis

Circulation (New York, N.Y.), 2001-05, Vol.103 (20), p.2453-2460

2001

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How to deal with multiple treatment or dose groups in randomized clinical trials? Another approach

Fundamental & clinical pharmacology, 2007-04, Vol.21 (2), p.155-156

Boissel, Jean-Pierre

2007

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J-shaped relationship between blood pressure and mortality in hypertensive patients: new insights from a meta-analysis of individual-patient data

Annals of internal medicine, 2002-03, Vol.136 (6), p.438

2002

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Using pharmacokinetic-pharmacodynamic relationships to predict the effect of poor compliance

Clinical pharmacokinetics, 2002, Vol.41 (1), p.1-6

2002

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QxDB: a generic database to support mathematical modelling in biology

Philosophical transactions of the Royal Society of London. Series A: Mathematical, physical, and engineering sciences, 2006-06, Vol.364 (1843), p.1517-1532

2006

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Antihypertensive drugs in very old people: a subgroup meta-analysis of randomised controlled trials

The Lancet (British edition), 1999-03, Vol.353 (9155), p.793-796

1999

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Reappraisal of metformin efficacy in the treatment of type 2 diabetes: a meta-analysis of randomised controlled trials

Using numerical modeling and simulation to assess the ethical burden in clinical trials and how it relates to the proportion of responders in a trial sample

Modeling the disruption of respiratory disease clinical trials by non-pharmaceutical COVID-19 interventions

Empirical methods for the validation of time-to-event mathematical models taking into account uncertainty and variability: application to EGFR + lung adenocarcinoma

Scientific and regulatory evaluation of mechanistic in silico drug and disease models in drug development: Building model credibility

Verifying and Validating Quantitative Systems Pharmacology and In Silico Models in Drug Development: Current Needs, Gaps, and Challenges

Risks of untreated and treated isolated systolic hypertension in the elderly: meta-analysis of outcome trials

High Risk versus Proportional Benefit: Modelling Equitable Strategies in Cardiovascular Prevention

From Clinical Trial Efficacy to Real-Life Effectiveness: Why Conventional Metrics do not Work

Solving the Evidence Interpretability Crisis in Health Technology Assessment: A Role for Mechanistic Models?

Chronic Lung Allograft Dysfunction: A Systematic Review of Mechanisms

A systematic review of the accuracy of ultrasound in the diagnosis of deep venous thrombosis in asymptomatic patients

The global risk approach should be better applied in French hypertensive patients: a comparison between simulation and observation studies

Pulsatile blood pressure component as predictor of mortality in hypertension: a meta-analysis of clinical trial control groups

An in silico target identification using Boolean network attractors: Avoiding pathological phenotypes

Low protein diets delay end‐stage renal disease in non‐diabetic adults with chronic renal failure

Effect model law: an approach for the implementation of personalized medicine

Clinical effects of β-adrenergic blockade in chronic heart failure : A meta-analysis of double-blind, placebo-controlled, randomized trials

A pharmacologically based multiscale mathematical model of angiogenesis and its use in investigating the efficacy of a new cancer treatment strategy

Comparison of 3 and 6 months of oral anticoagulant therapy after a first episode of proximal deep vein thrombosis or pulmonary embolism and comparison of 6 and 12 weeks of therapy after isolated calf deep vein thrombosis

How to deal with multiple treatment or dose groups in randomized clinical trials? Another approach

J-shaped relationship between blood pressure and mortality in hypertensive patients: new insights from a meta-analysis of individual-patient data

Using pharmacokinetic-pharmacodynamic relationships to predict the effect of poor compliance

QxDB: a generic database to support mathematical modelling in biology

Antihypertensive drugs in very old people: a subgroup meta-analysis of randomised controlled trials

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