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The grapefruit polyphenol naringenin inhibits multiple cardiac ion channels

Naunyn-Schmiedeberg's archives of pharmacology, 2022-06, Vol.395 (6), p.735-740

2022

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The atypic antipsychotic clozapine inhibits multiple cardiac ion channels

Naunyn-Schmiedeberg's archives of pharmacology, 2023, Vol.396 (1), p.161-166

2023

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Automated Patch-Clamp Methods for the hERG Cardiac Potassium Channel

Methods in molecular biology (Clifton, N.J.), 2017, Vol.1641, p.187

2017

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In vitro ion channel profile and ex vivo cardiac electrophysiology properties of the R(-) and S(+) enantiomers of hydroxychloroquine

European journal of pharmacology, 2022-01, Vol.915, p.174670-174670, Article 174670

2022

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Electrophysiological and Pharmacological Characterization of Human Inwardly Rectifying K ir 2.1 Channels on an Automated Patch-Clamp Platform

Assay and drug development technologies, 2019-04, Vol.17 (3), p.89-99

2019

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TC‐1734: An Orally Active Neuronal Nicotinic Acetylcholine Receptor Modulator with Antidepressant, Neuroprotective and Long‐Lasting Cognitive Effects

CNS drug reviews, 2004-06, Vol.10 (2), p.147-166

2004

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The effect of riluzole and mannitol on cerebral oedema after cryogenic injury in the mouse

Neuroscience letters, 1999-09, Vol.272 (3), p.143-146

1999

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Pharmacological properties of ureido-acetamides, new potent and selective non-peptide CCKB/gastrin receptor antagonists

European journal of pharmacology, 1994-09, Vol.262 (3), p.233-245

1994

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Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse

Human molecular genetics, 2003-09, Vol.12 (18), p.2277-2291

2003

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Altered Synaptic Plasticity and Memory Formation in Nitric Oxide Synthase Inhibitor-Treated Rats

Proceedings of the National Academy of Sciences - PNAS, 1993-10, Vol.90 (19), p.9191-9194

1993

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Impaired Long-Term Potentiation Induction in Dentate Gyrus of Calretinin-Deficient Mice

Proceedings of the National Academy of Sciences - PNAS, 1997-09, Vol.94 (19), p.10415-10420

1997

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Selective inhibition of inducible nitric oxide synthase prevents ischaemic brain injury

British journal of pharmacology, 1999-05, Vol.127 (2), p.546-552

1999

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Antisense Oligodeoxynucleotide to Inducible Nitric Oxide Synthase Protects Against Transient Focal Cerebral Ischemia-Induced Brain Injury

Journal of cerebral blood flow and metabolism, 2001-01, Vol.21 (1), p.15-21

2001

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RPR 119990, a novel alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid antagonist: synthesis, pharmacological properties, and activity in an animal model of amyotrophic lateral sclerosis

The Journal of pharmacology and experimental therapeutics, 2001-10, Vol.299 (1), p.314

2001

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9-Carboxymethyl-5H, 10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one-2-carbocylic acid (RPR117824): Selective anticonvulsive and neuroprotective AMPA antagonist

Bioorganic & medicinal chemistry, 2002-05, Vol.10 (5), p.1627-1637

2002

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Indeno[1,2-b]pyrazin-2,3-diones: A New Class of Antagonists at the Glycine Site of the NMDA Receptor with Potent in Vivo Activity

Journal of medicinal chemistry, 2000-06, Vol.43 (12), p.2371-2381

2000

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A Role for Nitric Oxide in Long-term Potentiation

The European journal of neuroscience, 1992-05, Vol.4 (5), p.420-424

1992

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Effect of Chronic Treatment with Riluzole on the Nigrostriatal Dopaminergic System in Weaver Mutant Mice

Experimental neurology, 2002-07, Vol.176 (1), p.247-253

2002

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Riluzole reduces hyperactivity of subthalamic neurons induced by unilateral 6-OHDA lesion in the rat brain

Movement disorders, 2001-11, Vol.16 (6), p.1110-1114

2001

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4,10-Dihydro-4-oxo-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-2-carboxylic acid derivatives: highly potent and selective AMPA receptors antagonists with in vivo activity

Bioorganic & medicinal chemistry letters, 2000-05, Vol.10 (10), p.1133

2000

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Bioisosteres of 9-carboxymethyl-4-oxo-imidazo[1,2-a]indeno-[1,2-e]pyrazin-2-carboxylic acid derivatives. Progress towards selective, potent in vivo AMPA antagonists with longer durations of action

Bioorganic & medicinal chemistry letters, 2001-01, Vol.11 (2), p.127-132

2001

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8-methylureido-10-amino-10-methyl-imidazo[1,2-a]indeno[1,2-e] pyrazine-4-ones : Highly in vivo potent and selective AMPA receptor antagonists

Bioorganic & medicinal chemistry, 2000-08, Vol.8 (8), p.2211-2217

2000

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Evidence for an endogenous cholecystokininergic balance in social memory

Neuroreport, 1992-10, Vol.3 (10), p.929-932

1992

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8-Methylureido-4,5-dihydro-4-oxo-10H-imidazo[1,2-a]indeno-[1,2-e]pyrazines : Highly potent in vivo AMPA antagonists

Bioorganic & medicinal chemistry letters, 2000-03, Vol.10 (6), p.591-596

2000

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Synthesis and potent anticonvulsant activities of 4-oxo-imidazo[1,2- a]indeno[1,2- e]pyrazin-8- and -9-carboxylic (acetic) acid AMPA antagonists

Bioorganic & medicinal chemistry letters, 2000-12, Vol.10 (24), p.2749-2754

2000

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The grapefruit polyphenol naringenin inhibits multiple cardiac ion channels

The atypic antipsychotic clozapine inhibits multiple cardiac ion channels

Automated Patch-Clamp Methods for the hERG Cardiac Potassium Channel

In vitro ion channel profile and ex vivo cardiac electrophysiology properties of the R(-) and S(+) enantiomers of hydroxychloroquine

Electrophysiological and Pharmacological Characterization of Human Inwardly Rectifying K ir 2.1 Channels on an Automated Patch-Clamp Platform

TC‐1734: An Orally Active Neuronal Nicotinic Acetylcholine Receptor Modulator with Antidepressant, Neuroprotective and Long‐Lasting Cognitive Effects

The effect of riluzole and mannitol on cerebral oedema after cryogenic injury in the mouse

Pharmacological properties of ureido-acetamides, new potent and selective non-peptide CCKB/gastrin receptor antagonists

Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse

Altered Synaptic Plasticity and Memory Formation in Nitric Oxide Synthase Inhibitor-Treated Rats

Impaired Long-Term Potentiation Induction in Dentate Gyrus of Calretinin-Deficient Mice

Selective inhibition of inducible nitric oxide synthase prevents ischaemic brain injury

Antisense Oligodeoxynucleotide to Inducible Nitric Oxide Synthase Protects Against Transient Focal Cerebral Ischemia-Induced Brain Injury

RPR 119990, a novel alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid antagonist: synthesis, pharmacological properties, and activity in an animal model of amyotrophic lateral sclerosis

9-Carboxymethyl-5H, 10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one-2-carbocylic acid (RPR117824): Selective anticonvulsive and neuroprotective AMPA antagonist

Indeno[1,2-b]pyrazin-2,3-diones: A New Class of Antagonists at the Glycine Site of the NMDA Receptor with Potent in Vivo Activity

A Role for Nitric Oxide in Long-term Potentiation

Effect of Chronic Treatment with Riluzole on the Nigrostriatal Dopaminergic System in Weaver Mutant Mice

Riluzole reduces hyperactivity of subthalamic neurons induced by unilateral 6-OHDA lesion in the rat brain

4,10-Dihydro-4-oxo-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-2-carboxylic acid derivatives: highly potent and selective AMPA receptors antagonists with in vivo activity

Bioisosteres of 9-carboxymethyl-4-oxo-imidazo[1,2-a]indeno-[1,2-e]pyrazin-2-carboxylic acid derivatives. Progress towards selective, potent in vivo AMPA antagonists with longer durations of action

8-methylureido-10-amino-10-methyl-imidazo[1,2-a]indeno[1,2-e] pyrazine-4-ones : Highly in vivo potent and selective AMPA receptor antagonists

Evidence for an endogenous cholecystokininergic balance in social memory

8-Methylureido-4,5-dihydro-4-oxo-10H-imidazo[1,2-a]indeno-[1,2-e]pyrazines : Highly potent in vivo AMPA antagonists

Synthesis and potent anticonvulsant activities of 4-oxo-imidazo[1,2- a]indeno[1,2- e]pyrazin-8- and -9-carboxylic (acetic) acid AMPA antagonists

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