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The c-Met Tyrosine Kinase Inhibitor JNJ-38877605 Causes Renal Toxicity through Species-Specific Insoluble Metabolite Formation

Clinical cancer research, 2015-05, Vol.21 (10), p.2297-2304

2015

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In Search of a Novel Anti-HIV Drug: Multidisciplinary Coordination in the Discovery of 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, Rilpivirine)

Journal of medicinal chemistry, 2005-03, Vol.48 (6), p.1901-1909

2005

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Clinical pharmacology of alcaftadine, a novel antihistamine for the prevention of allergic conjunctivitis

Journal of ocular pharmacology and therapeutics, 2011-04, Vol.27 (2), p.187-195

2011

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The Novel Azole R126638 Is a Selective Inhibitor of Ergosterol Synthesis in Candida albicans, Trichophyton spp., and Microsporum canis

Antimicrobial Agents and Chemotherapy, 2004-09, Vol.48 (9), p.3272-3278

2004

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Metabolism and disposition in rats, dogs, and humans of erdafitinib, an orally administered potent pan-fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor

Xenobiotica, 2021-02, Vol.51 (2), p.177-193

2021

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CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6α-hydroxylase activity in human liver microsomes

Biochemical pharmacology, 2002-12, Vol.64 (11), p.1579-1589

2002

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Strategies for absorption screening in drug discovery and development

Current topics in medicinal chemistry, 2001-11, Vol.1 (5), p.367-383

2001

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Correlation between the in vitro cytotoxicity to cultured fathead minnow fish cells and fish lethality data for 50 chemicals

Chemosphere (Oxford), 1992, Vol.25 (4), p.553-562

1992

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Cytotoxicity of mercury compounds in LLC-PK1, MDCK and human proximal tubular cells

Kidney international, 1995-02, Vol.47 (2), p.395-403

1995

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Abstract 2606: Rational combinations with the HDAC inhibitor, JNJ-26481585, in prostate cancer

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8_Supplement), p.2606-2606

2011

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Isolation and characterisation of the class alpha, mu and pi glutathione transferases in LLC-PK1 and pig kidney

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 1996-07, Vol.114 (3), p.261-267

1996

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Recombinant Escherichia coli cells immobilized in Ca-alginate beads for metabolite production

Biocatalysis and biotransformation, 2009, p.1-12

2009

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Absence of an active metabolite for the triazole antifungal pramiconazole

Acta dermato-venereologica, 2007, Vol.87 (1), p.22-26

2007

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Recombinant Escherichia coli cells immobilized in Ca-alginate beads for metabolite production

Biocatalysis and biotransformation, 2009, Vol.27 (5-6), p.348-359

2009

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CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6alpha-hydroxylase activity in human liver microsomes

Biochemical pharmacology, 2002-12, Vol.64 (11), p.1579-1589

2002

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Genetically characterized human liver cell lines (HEPG2) with distinct metabolic and toxicologic properties

Journal of hepatology, 2001-04, Vol.34, p.196-196

2001

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THE IMPORTANCE OF DOSE‐ AND TIME‐DEPENDENT PHARMACOKINETICS DURING EARLY METABOLITE SAFETY ASSESSMENT IN HUMANS

Metabolite Safety in Drug Development, 2016, p.293-303

2016

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The cytosolic glutathione S-transferase isoenzymes in the dog kidney cortex as compared with the corresponding MDCK renal cell line

Biochimica et biophysica acta, 1996-04, Vol.1311 (2), p.93-101

1996

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Characterization of the major cytosolic glutathione transferase in two monkey kidney derived cell lines

Cell biology international, 1993-06, Vol.17 (6), p.625-626

1993

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Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans

Pharmacogenetics (London), 2000-07, Vol.10 (5), p.415

2000

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The c-Met Tyrosine Kinase Inhibitor JNJ-38877605 Causes Renal Toxicity through Species-Specific Insoluble Metabolite Formation

In Search of a Novel Anti-HIV Drug: Multidisciplinary Coordination in the Discovery of 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, Rilpivirine)

Clinical pharmacology of alcaftadine, a novel antihistamine for the prevention of allergic conjunctivitis

The Novel Azole R126638 Is a Selective Inhibitor of Ergosterol Synthesis in Candida albicans, Trichophyton spp., and Microsporum canis

Metabolism and disposition in rats, dogs, and humans of erdafitinib, an orally administered potent pan-fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor

CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6α-hydroxylase activity in human liver microsomes

Strategies for absorption screening in drug discovery and development

Correlation between the in vitro cytotoxicity to cultured fathead minnow fish cells and fish lethality data for 50 chemicals

Cytotoxicity of mercury compounds in LLC-PK1, MDCK and human proximal tubular cells

Abstract 2606: Rational combinations with the HDAC inhibitor, JNJ-26481585, in prostate cancer

Isolation and characterisation of the class alpha, mu and pi glutathione transferases in LLC-PK1 and pig kidney

Recombinant Escherichia coli cells immobilized in Ca-alginate beads for metabolite production

Absence of an active metabolite for the triazole antifungal pramiconazole

Recombinant Escherichia coli cells immobilized in Ca-alginate beads for metabolite production

CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6alpha-hydroxylase activity in human liver microsomes

Genetically characterized human liver cell lines (HEPG2) with distinct metabolic and toxicologic properties

THE IMPORTANCE OF DOSE‐ AND TIME‐DEPENDENT PHARMACOKINETICS DURING EARLY METABOLITE SAFETY ASSESSMENT IN HUMANS

Correlations between factors determining the pharmacokinetics and antiviral activity of HIV-1 non-nucleoside reverse transcriptase inhibitors of the diaryltriazine and diarylpyrimidine classes of compounds

The cytosolic glutathione S-transferase isoenzymes in the dog kidney cortex as compared with the corresponding MDCK renal cell line

Characterization of the major cytosolic glutathione transferase in two monkey kidney derived cell lines

Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans

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