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A label-free, impedance-based real time assay to identify drug-induced toxicities and differentiate cytostatic from cytotoxic effects

Toxicology in vitro, 2013-08, Vol.27 (5), p.1589-1595

2013

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Inhibition of phosphodiesterase 2 increases neuronal cGMP, synaptic plasticity and memory performance

Neuropharmacology, 2004-12, Vol.47 (7), p.1081-1092

2004

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Gene Expression in Two Hepatic Cell Lines, Cultured Primary Hepatocytes, and Liver Slices Compared to the in Vivo Liver Gene Expression in Rats: Possible Implications for Toxicogenomics Use of in Vitro Systems

Toxicological sciences, 2003-06, Vol.73 (2), p.386-402

2003

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Kosten der Alzheimer-Erkrankung in Deutschland – aktuelle Ergebnisse der GERAS-Beobachtungsstudie

Gesundheitsökonomie & Qualitätsmanagement, 2016-10, Vol.21 (5), p.232-241

2016

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Minimizing DILI risk in drug discovery — A screening tool for drug candidates

Toxicology in vitro, 2015-12, Vol.30 (1), p.429-437

2015

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Molecular biology of 5-HT receptors

Neuropharmacology, 1994-03, Vol.33 (3), p.275-317

1994

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Trial of Prasinezumab in Early-Stage Parkinson’s Disease

The New England journal of medicine, 2022-08, Vol.387 (5), p.421-432

2022

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Continuation and effectiveness of tadalafil once daily during a 6-month observational study in erectile dysfunction: the EDATE study

International journal of clinical practice (Esher), 2014-09, Vol.68 (9), p.1087-1099

2014

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Characterization of Ro 04‐6790 and Ro 63‐0563: potent and selective antagonists at human and rat 5‐HT6 receptors

British journal of pharmacology, 1998-06, Vol.124 (3), p.556-562

1998

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Assessment of hepatotoxic liabilities by transcript profiling

Toxicology and applied pharmacology, 2005-09, Vol.207 (2), p.161-170

2005

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Involvement of 5‐HT6 receptors in nigro‐striatal function in rodents

British journal of pharmacology, 1998-12, Vol.125 (7), p.1562-1566

1998

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Investigation of stretching behaviour induced by the selective 5‐HT6 receptor antagonist, Ro 04–6790, in rats

British journal of pharmacology, 1999-04, Vol.126 (7), p.1537-1542

1999

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An in vitro study on 5-HT6 receptor antagonist induced hepatotoxicity based on biochemical assays and toxicogenomics

Toxicology in vitro, 2007-10, Vol.21 (7), p.1276-1286

2007

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P05-15 Large language models in drug development: deciphering discontinuationc causes to inform future strategies

Toxicology letters, 2024-09, Vol.399, p.S138-S138

2024

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Ultrastructure of the 5‐Hydroxytryptamine3 Receptor

Journal of neurochemistry, 1995-03, Vol.64 (3), p.1401-1405

1995

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Biomarkers of Flutamide-Bioactivation and Oxidative Stress In Vitro and In Vivo

Drug metabolism and disposition, 2016-04, Vol.44 (4), p.560-569

2016

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Functional and radioligand binding characterization of rat 5-HT6 receptors stably expressed in HEK293 cells

Neuropharmacology, 1997-04, Vol.36 (4-5), p.713-720

1997

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At-home Administration of Gantenerumab by Care Partners to People with Early Alzheimer’s Disease: Feasibility, Safety and Pharmacodynamic Impact

The Journal of Prevention of Alzheimer's Disease, 2024, Vol.11 (3), p.537-548

2024

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The Putative 5-ht6 Receptor: Localization and Function

Annals of the New York Academy of Sciences, 1998-12, Vol.861 (1), p.91-96

1998

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Identification of Residues in Transmembrane Regions III and VI that Contribute to the Ligand Binding Site of the Serotonin 5‐HT6 Receptor

Journal of neurochemistry, 1998-11, Vol.71 (5), p.2169-2177

1998

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Analysis of the ligand binding site of the 5-HT3 receptor using site directed mutagenesis: importance of glutamate 106

Neuropharmacology, 1997-04, Vol.36 (4-5), p.637

1997

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Discriminating Different Classes of Toxicants by Transcript Profiling

Environmental health perspectives, 2004-08, Vol.112 (12), p.1236-1248

2004

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Importance of adaption-time to galactose-medium for accurate in vitro assessment of mitochondrial toxicity

Toxicology letters, 2013-08, Vol.221, p.S148-S148

2013

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Effectiveness of Duloxetine Compared With Pregabalin and Gabapentin in Diabetic Peripheral Neuropathic Pain: Results from a German Observational Study

The Clinical journal of pain, 2014-10, Vol.30 (10), p.875-885

2014

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CAR-mediated, rodent-specific, mechanism of liver foci formation: Evidence from 8-day KO mouse study

Toxicology letters, 2013-08, Vol.221, p.S167-S167

2013

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A label-free, impedance-based real time assay to identify drug-induced toxicities and differentiate cytostatic from cytotoxic effects

Inhibition of phosphodiesterase 2 increases neuronal cGMP, synaptic plasticity and memory performance

Gene Expression in Two Hepatic Cell Lines, Cultured Primary Hepatocytes, and Liver Slices Compared to the in Vivo Liver Gene Expression in Rats: Possible Implications for Toxicogenomics Use of in Vitro Systems

Kosten der Alzheimer-Erkrankung in Deutschland – aktuelle Ergebnisse der GERAS-Beobachtungsstudie

Minimizing DILI risk in drug discovery — A screening tool for drug candidates

Molecular biology of 5-HT receptors

Trial of Prasinezumab in Early-Stage Parkinson’s Disease

Continuation and effectiveness of tadalafil once daily during a 6-month observational study in erectile dysfunction: the EDATE study

Characterization of Ro 04‐6790 and Ro 63‐0563: potent and selective antagonists at human and rat 5‐HT6 receptors

Assessment of hepatotoxic liabilities by transcript profiling

Involvement of 5‐HT6 receptors in nigro‐striatal function in rodents

Investigation of stretching behaviour induced by the selective 5‐HT6 receptor antagonist, Ro 04–6790, in rats

An in vitro study on 5-HT6 receptor antagonist induced hepatotoxicity based on biochemical assays and toxicogenomics

P05-15 Large language models in drug development: deciphering discontinuationc causes to inform future strategies

Ultrastructure of the 5‐Hydroxytryptamine3 Receptor

Biomarkers of Flutamide-Bioactivation and Oxidative Stress In Vitro and In Vivo

Functional and radioligand binding characterization of rat 5-HT6 receptors stably expressed in HEK293 cells

At-home Administration of Gantenerumab by Care Partners to People with Early Alzheimer’s Disease: Feasibility, Safety and Pharmacodynamic Impact

The Putative 5-ht6 Receptor: Localization and Function

Identification of Residues in Transmembrane Regions III and VI that Contribute to the Ligand Binding Site of the Serotonin 5‐HT6 Receptor

Analysis of the ligand binding site of the 5-HT3 receptor using site directed mutagenesis: importance of glutamate 106

Discriminating Different Classes of Toxicants by Transcript Profiling

Importance of adaption-time to galactose-medium for accurate in vitro assessment of mitochondrial toxicity

Effectiveness of Duloxetine Compared With Pregabalin and Gabapentin in Diabetic Peripheral Neuropathic Pain: Results from a German Observational Study

CAR-mediated, rodent-specific, mechanism of liver foci formation: Evidence from 8-day KO mouse study

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