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pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures

Journal of medicinal chemistry, 2015-05, Vol.58 (9), p.4066-4072

2015

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SDM: a server for predicting effects of mutations on protein stability

Nucleic acids research, 2017-07, Vol.45 (W1), p.W229

2017

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mCSM: predicting the effects of mutations in proteins using graph-based signatures

Bioinformatics, 2014-02, Vol.30 (3), p.335-342

2014

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Using a synthetic switch to regulate insulin receptor activation

Proceedings of the National Academy of Sciences - PNAS, 2021-08, Vol.118 (33), p.1

Blundell, Tom L

2021

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Human DNA-dependent protein kinase activation mechanism

Nature structural & molecular biology, 2023-02, Vol.30 (2), p.140

2023

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DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair

Science (American Association for the Advancement of Science), 2017-02, Vol.355 (6324), p.520-524

2017

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Protein crystallography and drug discovery: recollections of knowledge exchange between academia and industry

IUCrJ, 2017-07, Vol.4 (Pt 4), p.308-321

Blundell, Tom L

2017

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The first resolution revolution in protein structure analysis: X-ray diffraction of polypeptide conformations and globular protein folds in 1950s and 1960s

Progress in biophysics and molecular biology, 2021-12, Vol.167, p.32-40

Blundell, Tom L.

2021

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Does a More Precise Chemical Description of Protein–Ligand Complexes Lead to More Accurate Prediction of Binding Affinity?

Journal of chemical information and modeling, 2014-03, Vol.54 (3), p.944-955

2014

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From revolutionary technologies for understanding genes and proteins to a focus on new therapeutics

Progress in biophysics and molecular biology, 2021-09, Vol.164, p.1-2

Blundell, Tom L.

2021

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Prediction of impacts of mutations on protein structure and interactions: SDM, a statistical approach, and mCSM, using machine learning

Protein science, 2020-01, Vol.29 (1), p.247-257

2020

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A base measure of precision for protein stability predictors: structural sensitivity

BMC bioinformatics, 2021-02, Vol.22 (1), p.88-14, Article 88

2021

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Arpeggio: A Web Server for Calculating and Visualising Interatomic Interactions in Protein Structures

Journal of molecular biology, 2017-02, Vol.429 (3), p.365-371

2017

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Interdisciplinary research in physics, chemistry and biology is central to understanding biological processes

Progress in biophysics and molecular biology, 2020-10, Vol.156, p.1-2

Blundell, Tom L.

2020

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SDM--a server for predicting effects of mutations on protein stability and malfunction

Nucleic acids research, 2011-07, Vol.39 (Web Server issue), p.W215

2011

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Targeting tuberculosis using structure-guided fragment-based drug design

Drug discovery today, 2017-03, Vol.22 (3), p.546-554

2017

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Multicomponent assemblies in DNA-double-strand break repair by NHEJ

Current opinion in structural biology, 2019-04, Vol.55, p.154-160

2019

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Decoding the similarities and differences among mycobacterial species

PLoS neglected tropical diseases, 2017-08, Vol.11 (8), p.e0005883-e0005883

2017

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Systematic Investigation of the Data Set Dependency of Protein Stability Predictors

Journal of chemical information and modeling, 2020-10, Vol.60 (10), p.4772-4784

2020

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mCSM-lig: quantifying the effects of mutations on protein-small molecule affinity in genetic disease and emergence of drug resistance

Scientific reports, 2016-07, Vol.6 (1), p.29575-29575, Article 29575

2016

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Flexibility and small pockets at protein–protein interfaces: New insights into druggability

Progress in biophysics and molecular biology, 2015-10, Vol.119 (1), p.2-9

2015

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Structural biology and drug discovery for protein–protein interactions

Trends in pharmacological sciences (Regular ed.), 2012-05, Vol.33 (5), p.241-248

2012

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Dimers of DNA-PK create a stage for DNA double-strand break repair

Nature structural & molecular biology, 2021-01, Vol.28 (1), p.13

2021

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Three Simple Properties Explain Protein Stability Change upon Mutation

Journal of chemical information and modeling, 2021-04, Vol.61 (4), p.1981-1988

2021

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Mutations at protein-protein interfaces: Small changes over big surfaces have large impacts on human health

Progress in biophysics and molecular biology, 2017-09, Vol.128, p.3-13

2017

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pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures

SDM: a server for predicting effects of mutations on protein stability

mCSM: predicting the effects of mutations in proteins using graph-based signatures

Using a synthetic switch to regulate insulin receptor activation

Human DNA-dependent protein kinase activation mechanism

DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair

Protein crystallography and drug discovery: recollections of knowledge exchange between academia and industry

The first resolution revolution in protein structure analysis: X-ray diffraction of polypeptide conformations and globular protein folds in 1950s and 1960s

Does a More Precise Chemical Description of Protein–Ligand Complexes Lead to More Accurate Prediction of Binding Affinity?

From revolutionary technologies for understanding genes and proteins to a focus on new therapeutics

Prediction of impacts of mutations on protein structure and interactions: SDM, a statistical approach, and mCSM, using machine learning

A base measure of precision for protein stability predictors: structural sensitivity

Arpeggio: A Web Server for Calculating and Visualising Interatomic Interactions in Protein Structures

Interdisciplinary research in physics, chemistry and biology is central to understanding biological processes

SDM--a server for predicting effects of mutations on protein stability and malfunction

Targeting tuberculosis using structure-guided fragment-based drug design

Multicomponent assemblies in DNA-double-strand break repair by NHEJ

Decoding the similarities and differences among mycobacterial species

Systematic Investigation of the Data Set Dependency of Protein Stability Predictors

mCSM-lig: quantifying the effects of mutations on protein-small molecule affinity in genetic disease and emergence of drug resistance

Flexibility and small pockets at protein–protein interfaces: New insights into druggability

Structural biology and drug discovery for protein–protein interactions

Dimers of DNA-PK create a stage for DNA double-strand break repair

Three Simple Properties Explain Protein Stability Change upon Mutation

Mutations at protein-protein interfaces: Small changes over big surfaces have large impacts on human health

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