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Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

Science (American Association for the Advancement of Science), 2013-03, Vol.339 (6124), p.1216-1219

2013

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The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept

Nature reviews. Drug discovery, 2007-05, Vol.6 (5), p.357-372

2007

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Discovery of Thieno[3,2‑d]pyrimidine-6-carboxamides as Potent Inhibitors of SIRT1, SIRT2, and SIRT3

Journal of medicinal chemistry, 2013-05, Vol.56 (9), p.3666-3679

2013

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Crystallographic structure of a small molecule SIRT1 activator-enzyme complex

Nature communications, 2015-07, Vol.6 (1), p.7645, Article 7645

2015

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SIRT1 Modulation as a Novel Approach to the Treatment of Diseases of Aging

Journal of medicinal chemistry, 2011-01, Vol.54 (2), p.417-432

2011

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Discovery and evaluation of pyrazolo[1,5- a]pyrimidines as neuropeptide Y1 receptor antagonists

Bioorganic & medicinal chemistry letters, 2011-05, Vol.21 (9), p.2641-2645

2011

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Discovery of Novel 6,6-Heterocycles as Transient Receptor Potential Vanilloid (TRPV1) Antagonists

Journal of medicinal chemistry, 2010-04, Vol.53 (8), p.3330-3348

2010

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Design, Synthesis, and Biological Evaluation of Substituted 2-Cyclohexyl-4-phenyl-1H-imidazoles: Potent and Selective Neuropeptide Y Y5-Receptor Antagonists

Journal of medicinal chemistry, 2004-04, Vol.47 (9), p.2318-2325

2004

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Pyrido[2,3-b]pyrazines, discovery of TRPV1 antagonists with reduced potential for the formation of reactive metabolites

Bioorganic & medicinal chemistry letters, 2010-08, Vol.20 (15), p.4359-4363

2010

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Aminoquinazolines as TRPV1 antagonists: Modulation of drug-like properties through the exploration of 2-position substitution

Bioorganic & medicinal chemistry, 2008-08, Vol.18 (16), p.4573-4577

2008

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The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept

Nature reviews. Drug discovery, 2007-05, Vol.6 (5), p.1-1

2007

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From arylureas to biarylamides to aminoquinazolines: Discovery of a novel, potent TRPV1 antagonist

Bioorganic & medicinal chemistry letters, 2006-10, Vol.16 (19), p.5217-5221

2006

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Substituted 3-(2-benzoxazyl)-benzimidazol-2-(1H)-ones : A new class of GABAA brain receptor ligands

Bioorganic & medicinal chemistry letters, 2000-12, Vol.10 (24), p.2723-2726

2000

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The chemistry of vicinal tricarbonyls. Use of vinyl and acetylenic derivatives in the synthesis of substituted indoles

Tetrahedron letters, 1994-12, Vol.35 (52), p.9787-9790

1994

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Bis-heteroannulation. 15. Enantiospecific syntheses of (+)- and (-)-norsecurinine

Journal of the American Chemical Society, 1991-07, Vol.113 (14), p.5384-5392

1991

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Erratum: The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept

Nature reviews. Drug discovery, 2007-06, Vol.6 (6), p.500-500

2007

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Design, Synthesis, and Biological Evaluation of Substituted 2-Cyclohexyl-4-phenyl-1 H -imidazoles: Potent and Selective Neuropeptide Y Y5-Receptor Antagonists

Journal of medicinal chemistry, 2004-04, Vol.47 (9), p.2318-2325

2004

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Substituted 3-(2-benzoxazyl)-benzimidazol-2-(1 H)-ones: A new class of GABA A brain receptor ligands

Bioorganic & medicinal chemistry letters, 2000-12, Vol.10 (24), p.2723-2726

2000

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The conversion of carboxylic acids to keto phosphorane precursors of 1,2,3-vicinal tricarbonyl compounds

Tetrahedron letters, 1992-09, Vol.33 (40), p.6003-6006

1992

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Total synthesis of (+)- and (−)-norsecurinine

Tetrahedron letters, 1989, Vol.30 (51), p.7173-7176

1989

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The conversion of car☐ylic acids to keto phosphorane precursors of 1,2,3-vicinal tricarbonyl compounds

Tetrahedron letters, 1992-09, Vol.33 (40), p.6003-6006

1992

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Total synthesis of (+)- and (-)-norsecurinine

Blum, Charles A

1990

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ChemInform Abstract: Substituted 3-(2-Benzoxazyl)-benzimidazol-2-(1H)-ones: A New Class of GABAA Brain Receptor Ligands

ChemInform, 2001-03, Vol.32 (10), p.no-no

2001

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ChemInform Abstract: Substituted 3‐(2‐Benzoxazyl)‐benzimidazol‐2‐(1H)‐ones: A New Class of GABA A Brain Receptor Ligands

ChemInform, 2001-03, Vol.32 (10)

2001

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Improved syntheses of 6-hydroxy-5-methoxy- and 5-hydroxy-6-methoxyindoles and their O-acetates, analogs of natural eumelanin precursors

Journal of heterocyclic chemistry, 1987-07, Vol.24 (4), p.941-943

1987

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Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept

Discovery of Thieno[3,2‑d]pyrimidine-6-carboxamides as Potent Inhibitors of SIRT1, SIRT2, and SIRT3

Crystallographic structure of a small molecule SIRT1 activator-enzyme complex

SIRT1 Modulation as a Novel Approach to the Treatment of Diseases of Aging

Discovery and evaluation of pyrazolo[1,5- a]pyrimidines as neuropeptide Y1 receptor antagonists

Discovery of Novel 6,6-Heterocycles as Transient Receptor Potential Vanilloid (TRPV1) Antagonists

Design, Synthesis, and Biological Evaluation of Substituted 2-Cyclohexyl-4-phenyl-1H-imidazoles: Potent and Selective Neuropeptide Y Y5-Receptor Antagonists

Pyrido[2,3-b]pyrazines, discovery of TRPV1 antagonists with reduced potential for the formation of reactive metabolites

Aminoquinazolines as TRPV1 antagonists: Modulation of drug-like properties through the exploration of 2-position substitution

The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept

From arylureas to biarylamides to aminoquinazolines: Discovery of a novel, potent TRPV1 antagonist

Substituted 3-(2-benzoxazyl)-benzimidazol-2-(1H)-ones : A new class of GABAA brain receptor ligands

The chemistry of vicinal tricarbonyls. Use of vinyl and acetylenic derivatives in the synthesis of substituted indoles

Bis-heteroannulation. 15. Enantiospecific syntheses of (+)- and (-)-norsecurinine

Erratum: The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept

Design, Synthesis, and Biological Evaluation of Substituted 2-Cyclohexyl-4-phenyl-1 H -imidazoles: Potent and Selective Neuropeptide Y Y5-Receptor Antagonists

Substituted 3-(2-benzoxazyl)-benzimidazol-2-(1 H)-ones: A new class of GABA A brain receptor ligands

The conversion of carboxylic acids to keto phosphorane precursors of 1,2,3-vicinal tricarbonyl compounds

Total synthesis of (+)- and (−)-norsecurinine

The conversion of car☐ylic acids to keto phosphorane precursors of 1,2,3-vicinal tricarbonyl compounds

Total synthesis of (+)- and (-)-norsecurinine

ChemInform Abstract: Substituted 3-(2-Benzoxazyl)-benzimidazol-2-(1H)-ones: A New Class of GABAA Brain Receptor Ligands

ChemInform Abstract: Substituted 3‐(2‐Benzoxazyl)‐benzimidazol‐2‐(1H)‐ones: A New Class of GABA A Brain Receptor Ligands

Improved syntheses of 6-hydroxy-5-methoxy- and 5-hydroxy-6-methoxyindoles and their O-acetates, analogs of natural eumelanin precursors

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