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Crystal structure and stability of gyrase–fluoroquinolone cleaved complexes from Mycobacterium tuberculosis

Proceedings of the National Academy of Sciences - PNAS, 2016-02, Vol.113 (7), p.1706-1713

2016

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The phage defence island of a multidrug resistant plasmid uses both BREX and type IV restriction for complementary protection from viruses

Nucleic acids research, 2021-11, Vol.49 (19), p.11257-11273

2021

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Genomic and taxonomic evaluation of 38 Treponema prophage sequences

BMC genomics, 2024-06, Vol.25 (1), p.549-15

2024

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Fluoroquinolone interactions with Mycobacterium tuberculosis gyrase: Enhancing drug activity against wild-type and resistant gyrase

Proceedings of the National Academy of Sciences - PNAS, 2016-02, Vol.113 (7), p.E839-E846

2016

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Viral evasion of a bacterial suicide system by RNA-based molecular mimicry enables infectious altruism

PLoS genetics, 2012-10, Vol.8 (10), p.e1003023

2012

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Inducible auto-phosphorylation regulates a widespread family of nucleotidyltransferase toxins

Nature communications, 2024-09, Vol.15 (1), p.7719-20, Article 7719

2024

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The novel anti-phage system Shield co-opts an RmuC domain to mediate phage defense across Pseudomonas species

PLoS genetics, 2023-06, Vol.19 (6), p.e1010784-e1010784

2023

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phage abortive infection system, ToxIN, functions as a protein-RNA toxin-antitoxin pair

Proceedings of the National Academy of Sciences - PNAS, 2009-01, Vol.106 (3), p.894-899

2009

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MenT nucleotidyltransferase toxins extend tRNA acceptor stems and can be inhibited by asymmetrical antitoxin binding

Nature communications, 2023-08, Vol.14 (1), p.4644-4644, Article 4644

2023

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A comprehensive structural analysis of the ATPase domain of human DNA topoisomerase II beta bound to AMPPNP, ADP, and the bisdioxopiperazine, ICRF193

Structure (London), 2022-08, Vol.30 (8), p.1129-1145.e3

2022

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Allophycocyanin A is a carbon dioxide receptor in the cyanobacterial phycobilisome

Nature communications, 2022-09, Vol.13 (1), p.5289-5289, Article 5289

2022

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Conserved domains can be found across distinct phage defence systems

Molecular microbiology, 2023-07, Vol.120 (1), p.45-53

2023

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Anticancer Ruthenium Complexes with HDAC Isoform Selectivity

Molecules (Basel, Switzerland), 2020-05, Vol.25 (10), p.2383

2020

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Viruses wrap up bacterial defence systems

Nature (London), 2024-01, Vol.625 (7994), p.250-251

2024

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Crystal structure of the BREX phage defence protein BrxA

Current research in structural biology, 2022-01, Vol.4, p.211-219

2022

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Selectivity and self-assembly in the control of a bacterial toxin by an antitoxic noncoding RNA pseudoknot

Proceedings of the National Academy of Sciences - PNAS, 2013-01, Vol.110 (3), p.820-821

2013

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Mechanism of Action of Mycobacterium tuberculosis Gyrase Inhibitors: A Novel Class of Gyrase Poisons

ACS infectious diseases, 2018-08, Vol.4 (8), p.1211-1222

2018

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Toxin–antitoxin systems as mediators of phage defence and the implications for abortive infection

Current opinion in microbiology, 2023-06, Vol.73, p.102293-102293, Article 102293

2023

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Isolation and Characterisation of Bacteriophages with Activity against Invasive Non-Typhoidal Salmonella Causing Bloodstream Infection in Malawi

Viruses, 2021-03, Vol.13 (3), p.478

2021

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Using energy to go downhill-a genoprotective role for ATPase activity in DNA topoisomerase II

Nucleic acids research, 2024-02, Vol.52 (3), p.1313

2024

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Antitoxin autoregulation of M. tuberculosis toxin-antitoxin expression through negative cooperativity arising from multiple inverted repeat sequences

Biochemical journal, 2020-06, Vol.477 (12), p.2401-2419

2020

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Naturally mutagenic sequence diversity in a human type II topoisomerase

Proceedings of the National Academy of Sciences - PNAS, 2023-07, Vol.120 (28), p.e2302064120-e2302064120

2023

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A widespread family of WYL-domain transcriptional regulators co-localizes with diverse phage defence systems and islands

Nucleic acids research, 2022-05, Vol.50 (9), p.5191-5207

2022

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Recognition of DNA Supercoil Geometry by Mycobacterium tuberculosis Gyrase

Biochemistry (Easton), 2017-10, Vol.56 (40), p.5440-5448

2017

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Toxin release by conditional remodelling of ParDE1 from Mycobacterium tuberculosis leads to gyrase inhibition

Nucleic acids research, 2024-02, Vol.52 (4), p.1909

2024

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Crystal structure and stability of gyrase–fluoroquinolone cleaved complexes from Mycobacterium tuberculosis

The phage defence island of a multidrug resistant plasmid uses both BREX and type IV restriction for complementary protection from viruses

Genomic and taxonomic evaluation of 38 Treponema prophage sequences

Fluoroquinolone interactions with Mycobacterium tuberculosis gyrase: Enhancing drug activity against wild-type and resistant gyrase

Viral evasion of a bacterial suicide system by RNA-based molecular mimicry enables infectious altruism

Inducible auto-phosphorylation regulates a widespread family of nucleotidyltransferase toxins

The novel anti-phage system Shield co-opts an RmuC domain to mediate phage defense across Pseudomonas species

phage abortive infection system, ToxIN, functions as a protein-RNA toxin-antitoxin pair

MenT nucleotidyltransferase toxins extend tRNA acceptor stems and can be inhibited by asymmetrical antitoxin binding

A comprehensive structural analysis of the ATPase domain of human DNA topoisomerase II beta bound to AMPPNP, ADP, and the bisdioxopiperazine, ICRF193

Allophycocyanin A is a carbon dioxide receptor in the cyanobacterial phycobilisome

Conserved domains can be found across distinct phage defence systems

Anticancer Ruthenium Complexes with HDAC Isoform Selectivity

Viruses wrap up bacterial defence systems

Crystal structure of the BREX phage defence protein BrxA

Selectivity and self-assembly in the control of a bacterial toxin by an antitoxic noncoding RNA pseudoknot

Mechanism of Action of Mycobacterium tuberculosis Gyrase Inhibitors: A Novel Class of Gyrase Poisons

Toxin–antitoxin systems as mediators of phage defence and the implications for abortive infection

Isolation and Characterisation of Bacteriophages with Activity against Invasive Non-Typhoidal Salmonella Causing Bloodstream Infection in Malawi

Using energy to go downhill-a genoprotective role for ATPase activity in DNA topoisomerase II

Antitoxin autoregulation of M. tuberculosis toxin-antitoxin expression through negative cooperativity arising from multiple inverted repeat sequences

Naturally mutagenic sequence diversity in a human type II topoisomerase

A widespread family of WYL-domain transcriptional regulators co-localizes with diverse phage defence systems and islands

Recognition of DNA Supercoil Geometry by Mycobacterium tuberculosis Gyrase

Toxin release by conditional remodelling of ParDE1 from Mycobacterium tuberculosis leads to gyrase inhibition

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