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FN3: a new protein scaffold reaches the clinic

Drug discovery today, 2009-10, Vol.14 (19), p.949-955

2009

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Establishing in vitro in vivo correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics

mAbs, 2018-02, Vol.10 (2), p.244-255

2018

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IL-21 receptor is critical for the development of memory B cell responses

The Journal of immunology (1950), 2011-01, Vol.186 (2), p.667-674

2011

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In vitro affinity optimization of an anti-BDNF monoclonal antibody translates to improved potency in targeting chronic pain states in vivo

mAbs, 2020-01, Vol.12 (1), p.1755000-1755000

2020

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Discovery and optimization of a novel anti-GUCY2c x CD3 bispecific antibody for the treatment of solid tumors

mAbs, 2021-01, Vol.13 (1), p.1850395

2021

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Development of PF-06671008, a Highly Potent Anti-P-cadherin/Anti-CD3 Bispecific DART Molecule with Extended Half-Life for the Treatment of Cancer

Antibodies (Basel), 2016-03, Vol.5 (1), p.6

2016

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C. elegans CARMIL negatively regulates UNC-73/Trio function during neuronal development

Development (Cambridge), 2009-04, Vol.136 (7), p.1201-1210

2009

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Abl kinase inhibits the engulfment of apoptotic [corrected] cells in Caenorhabditis elegans

PLoS biology, 2009-04, Vol.7 (4), p.e99-e99

2009

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In vitro potency, pharmacokinetic profiles and pharmacological activity of optimized anti-IL-21R antibodies in a mouse model of lupus

mAbs, 2010-05, Vol.2 (3), p.335-346

2010

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Fibronectin regulates assembly of actin filaments and focal contacts in cultured cells via the heparin-binding site in repeat III13

Molecular biology of the cell, 1999-05, Vol.10 (5), p.1521-1536

1999

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The Caenorhabditis elegans Gene unc-76 and its Human Homologs Define a new Gene Family Involved in Axonal Outgrowth and Fasciculation

Proceedings of the National Academy of Sciences - PNAS, 1997-04, Vol.94 (7), p.3414-3419

1997

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Correlation of pharmacodynamic activity, pharmacokinetics, and anti-product antibody responses to anti-IL-21R antibody therapeutics following IV administration to cynomolgus monkeys

Journal of translational medicine, 2010-04, Vol.8 (1), p.41-41, Article 41

2010

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Correction: Abl Kinase Inhibits the Engulfment of Apopotic Cells in Caenorhabditis elegans

PLoS biology, 2009-06, Vol.7 (6)

2009

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Development and application of a biomarker assay for determining the pharmacodynamic activity of an antagonist candidate biotherapeutic antibody to IL21R in whole blood

Journal of translational medicine, 2010-05, Vol.8 (1), p.51-51, Article 51

2010

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A Novel GUCY2C-CD3 T-Cell Engaging Bispecific Construct (PF-07062119) for the Treatment of Gastrointestinal Cancers

Clinical cancer research, 2020-05, Vol.26 (9), p.2188-2202

2020

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Assessing agonistic potential of a candidate therapeutic anti-IL21R antibody

Journal of translational medicine, 2010-05, Vol.8 (1), p.50-50, Article 50

2010

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IL-21 receptor is required for the systemic accumulation of activated B and T lymphocytes in MRL/MpJ-Fas(lpr/lpr)/J mice

The Journal of immunology (1950), 2012-02, Vol.188 (4), p.1656-1667

2012

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Phage Display: A Powerful Technology for the Generation of High-Specificity Affinity Reagents from Alternative Immune Sources

Methods in molecular biology (Clifton, N.J.), 2017-01, Vol.1485, p.85

2017

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Optimized Generation of High-Affinity, High-Specificity Single-Chain Fv Antibodies from Multi-Antigen Immunized Chickens

Methods in molecular biology (Clifton, N.J.), 2017, Vol.1485, p.319

2017

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Metabolic Engineering of Glycofusion Bispecific Antibodies for α-Dystroglycanopathies

Antibodies (Basel), 2024-10, Vol.13 (4), p.83

2024

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Comprehensive Interrogation of a Minimalist Synthetic CDR-H3 Library and Its Ability to Generate Antibodies with Therapeutic Potential

Journal of molecular biology, 2013-05, Vol.425 (10), p.1712-1730

2013

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Quantitative Analysis of Target Coverage and Germinal Center Response by a CXCL13 Neutralizing Antibody in a T-Dependent Mouse Immunization Model

Pharmaceutical research, 2014-03, Vol.31 (3), p.635-648

2014

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Abl Kinase Inhibits the Engulfment of Apopotic Cells in Caenorhabditis elegans

PLoS biology, 2009-04, Vol.7 (4), p.e1000099

2009

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Phage display: a powerful technology for the generation of high specificity affinity reagents from alternative immune sources

Methods in molecular biology (Clifton, N.J.), 2011-01, Vol.681, p.87

2011

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FN3: a new protein scaffold reaches the clinic

Establishing in vitro in vivo correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics

IL-21 receptor is critical for the development of memory B cell responses

In vitro affinity optimization of an anti-BDNF monoclonal antibody translates to improved potency in targeting chronic pain states in vivo

Discovery and optimization of a novel anti-GUCY2c x CD3 bispecific antibody for the treatment of solid tumors

Development of PF-06671008, a Highly Potent Anti-P-cadherin/Anti-CD3 Bispecific DART Molecule with Extended Half-Life for the Treatment of Cancer

C. elegans CARMIL negatively regulates UNC-73/Trio function during neuronal development

Abl kinase inhibits the engulfment of apoptotic [corrected] cells in Caenorhabditis elegans

In vitro potency, pharmacokinetic profiles and pharmacological activity of optimized anti-IL-21R antibodies in a mouse model of lupus

Fibronectin regulates assembly of actin filaments and focal contacts in cultured cells via the heparin-binding site in repeat III13

The Caenorhabditis elegans Gene unc-76 and its Human Homologs Define a new Gene Family Involved in Axonal Outgrowth and Fasciculation

Correlation of pharmacodynamic activity, pharmacokinetics, and anti-product antibody responses to anti-IL-21R antibody therapeutics following IV administration to cynomolgus monkeys

Correction: Abl Kinase Inhibits the Engulfment of Apopotic Cells in Caenorhabditis elegans

Development and application of a biomarker assay for determining the pharmacodynamic activity of an antagonist candidate biotherapeutic antibody to IL21R in whole blood

A Novel GUCY2C-CD3 T-Cell Engaging Bispecific Construct (PF-07062119) for the Treatment of Gastrointestinal Cancers

Assessing agonistic potential of a candidate therapeutic anti-IL21R antibody

IL-21 receptor is required for the systemic accumulation of activated B and T lymphocytes in MRL/MpJ-Fas(lpr/lpr)/J mice

Phage Display: A Powerful Technology for the Generation of High-Specificity Affinity Reagents from Alternative Immune Sources

Optimized Generation of High-Affinity, High-Specificity Single-Chain Fv Antibodies from Multi-Antigen Immunized Chickens

Metabolic Engineering of Glycofusion Bispecific Antibodies for α-Dystroglycanopathies

Comprehensive Interrogation of a Minimalist Synthetic CDR-H3 Library and Its Ability to Generate Antibodies with Therapeutic Potential

Quantitative Analysis of Target Coverage and Germinal Center Response by a CXCL13 Neutralizing Antibody in a T-Dependent Mouse Immunization Model

Abl Kinase Inhibits the Engulfment of Apopotic Cells in Caenorhabditis elegans

CDR-restricted engineering of native human scFvs creates highly stable and soluble bifunctional antibodies for subcutaneous delivery

Phage display: a powerful technology for the generation of high specificity affinity reagents from alternative immune sources

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