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Design, Synthesis, Docking, and Biological Evaluation of Novel Diazide-Containing Isoxazole- and Pyrazole-Based Histone Deacetylase Probes

Journal of medicinal chemistry, 2011-07, Vol.54 (13), p.4350-4364

2011

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Novel histone deacetylase 8 ligands without a zinc chelating group: Exploring an ‘upside-down’ binding pose

Bioorganic & medicinal chemistry letters, 2012-11, Vol.22 (21), p.6621-6627

2012

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Photoreactive “Nanorulers” Detect a Novel Conformation of Full Length HDAC3-SMRT Complex in Solution

ACS chemical biology, 2013-11, Vol.8 (11), p.2538-2549

2013

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Retention of Misfolded Mutant Transthyretin by the Chaperone BiP/GRP78 Mitigates Amyloidogenesis

Journal of molecular biology, 2006-02, Vol.356 (2), p.469-482

2006

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From a Natural Product Lead to the Identification of Potent and Selective Benzofuran-3-yl-(indol-3-yl)maleimides as Glycogen Synthase Kinase 3β Inhibitors That Suppress Proliferation and Survival of Pancreatic Cancer Cells

Journal of medicinal chemistry, 2009-04, Vol.52 (7), p.1853-1863

2009

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Binding Ensemble Profiling with Photoaffinity Labeling (BEProFL) Approach: Mapping the Binding Poses of HDAC8 Inhibitors

Journal of medicinal chemistry, 2009-11, Vol.52 (22), p.7003-7013

2009

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Structure-Based Design Leads to the Identification of Lithium Mimetics That Block Mania-like Effects in Rodents. Possible New GSK-3β Therapies for Bipolar Disorders

Journal of the American Chemical Society, 2007-07, Vol.129 (26), p.8328-8332

2007

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Catalytically Active Monomer of Glutathione S-Transferase π and Key Residues Involved in the Electrostatic Interaction between Subunits

The Journal of biological chemistry, 2008-11, Vol.283 (47), p.32880-32888

2008

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Highly Potent and Specific GSK-3β Inhibitors That Block Tau Phosphorylation and Decrease α-Synuclein Protein Expression in a Cellular Model of Parkinson's Disease

ChemMedChem, 2006-02, Vol.1 (2), p.256-266

2006

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Interaction of Murine BiP/GRP78 with the DnaJ Homologue MTJ1

The Journal of biological chemistry, 2000-06, Vol.275 (26), p.19620-19627

2000

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Inhibitors of Human Histone Deacetylase: Synthesis and Enzyme Assay of Hydroxamates with Piperazine Linker

Archiv der Pharmazie (Weinheim), 2010-03, Vol.343 (3), p.167-172

2010

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BIP co-chaperone MTJ1/ERDJ1 interacts with inter-α-trypsin inhibitor heavy chain 4

Biochemical and biophysical research communications, 2005-12, Vol.338 (3), p.1467-1477

2005

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Structural and Functional Consequences of Inactivation of Human Glutathione S-Transferase P1-1 Mediated by the Catechol Metabolite of Equine Estrogens, 4-Hydroxyequilenin

Biochemistry (Easton), 2001-04, Vol.40 (15), p.4811-4820

2001

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Inhibition of Glutathione S-Transferase Activity by the Quinoid Metabolites of Equine Estrogens

Chemical research in toxicology, 1998-07, Vol.11 (7), p.758-765

1998

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Inhibition of Cellular Enzymes by Equine Catechol Estrogens in Human Breast Cancer Cells: Specificity for Glutathione S-Transferase P1-1

Chemical research in toxicology, 2002-07, Vol.15 (7), p.935-942

2002

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Substrate Binding Induces Depolymerization of the C-terminal Peptide Binding Domain of Murine GRP78/BiP

The Journal of biological chemistry, 1998-10, Vol.273 (41), p.26827-26835

1998

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Isolation, Expression, and Characterization of Fully Functional Nontoxic BiP/GRP78 Mutants

Protein expression and purification, 2001-06, Vol.22 (1), p.148-158

2001

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The SANT2 Domain of the Murine Tumor Cell DnaJ-like Protein 1 Human Homologue Interacts with α1-Antichymotrypsin and Kinetically Interferes with Its Serpin Inhibitory Activity

The Journal of biological chemistry, 2004-03, Vol.279 (12), p.11432-11443

2004

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Use of molecular modeling, docking, and 3D-QSAR studies for the determination of the binding mode of benzofuran-3-yl-(indol-3-yl)maleimides as GSK-3β inhibitors

Journal of molecular modeling, 2009-12, Vol.15 (12), p.1463-1479

2009

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Catalytically Active Monomer of Glutathione S-Transferase Ï and Key Residues Involved in the Electrostatic Interaction between Subunits

The Journal of biological chemistry, 2008-11, Vol.283 (47), p.32880

2008

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Structure-based design leads to the identification of lithium mimetics that block mania-like effects in rodents. possible new GSK-3beta therapies for bipolar disorders

Journal of the American Chemical Society, 2007-07, Vol.129 (26), p.8328

2007

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A Metabolite of Equine Estrogens, 4-Hydroxyequilenin, Induces DNA Damage and Apoptosis in Breast Cancer Cell Lines

Chemical research in toxicology, 2000-05, Vol.13 (5), p.342-350

2000

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Retention of Misfolded Mutant Transthyretin by the Chaperone BiP/GRP78 Mitigates Amyloidogenesi

Journal of molecular biology, 2006, Vol.356 (2), p.469

2006

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Use of Molecular Modelling, Docking, and 3D-QSAR Studies for the Determination of the Binding Mode of 3-Benzofuranyl-4-indolyl-maleimides as GSK-3β Inhibitors

Journal of molecular modeling, 2009-05, Vol.15 (12), p.1463-1479

2009

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The SANT2 Domain of the Murine Tumor Cell DnaJ-like Protein 1 Human Homologue Interacts with Î±1-Antichymotrypsin and Kinetically Interferes with Its Serpin Inhibitory Activity

The Journal of biological chemistry, 2004-03, Vol.279 (12), p.11432

2004

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Design, Synthesis, Docking, and Biological Evaluation of Novel Diazide-Containing Isoxazole- and Pyrazole-Based Histone Deacetylase Probes

Novel histone deacetylase 8 ligands without a zinc chelating group: Exploring an ‘upside-down’ binding pose

Photoreactive “Nanorulers” Detect a Novel Conformation of Full Length HDAC3-SMRT Complex in Solution

Retention of Misfolded Mutant Transthyretin by the Chaperone BiP/GRP78 Mitigates Amyloidogenesis

From a Natural Product Lead to the Identification of Potent and Selective Benzofuran-3-yl-(indol-3-yl)maleimides as Glycogen Synthase Kinase 3β Inhibitors That Suppress Proliferation and Survival of Pancreatic Cancer Cells

Binding Ensemble Profiling with Photoaffinity Labeling (BEProFL) Approach: Mapping the Binding Poses of HDAC8 Inhibitors

Structure-Based Design Leads to the Identification of Lithium Mimetics That Block Mania-like Effects in Rodents. Possible New GSK-3β Therapies for Bipolar Disorders

Catalytically Active Monomer of Glutathione S-Transferase π and Key Residues Involved in the Electrostatic Interaction between Subunits

Highly Potent and Specific GSK-3β Inhibitors That Block Tau Phosphorylation and Decrease α-Synuclein Protein Expression in a Cellular Model of Parkinson's Disease

Interaction of Murine BiP/GRP78 with the DnaJ Homologue MTJ1

Inhibitors of Human Histone Deacetylase: Synthesis and Enzyme Assay of Hydroxamates with Piperazine Linker

BIP co-chaperone MTJ1/ERDJ1 interacts with inter-α-trypsin inhibitor heavy chain 4

Structural and Functional Consequences of Inactivation of Human Glutathione S-Transferase P1-1 Mediated by the Catechol Metabolite of Equine Estrogens, 4-Hydroxyequilenin

Inhibition of Glutathione S-Transferase Activity by the Quinoid Metabolites of Equine Estrogens

Inhibition of Cellular Enzymes by Equine Catechol Estrogens in Human Breast Cancer Cells: Specificity for Glutathione S-Transferase P1-1

Substrate Binding Induces Depolymerization of the C-terminal Peptide Binding Domain of Murine GRP78/BiP

Isolation, Expression, and Characterization of Fully Functional Nontoxic BiP/GRP78 Mutants

The SANT2 Domain of the Murine Tumor Cell DnaJ-like Protein 1 Human Homologue Interacts with α1-Antichymotrypsin and Kinetically Interferes with Its Serpin Inhibitory Activity

Use of molecular modeling, docking, and 3D-QSAR studies for the determination of the binding mode of benzofuran-3-yl-(indol-3-yl)maleimides as GSK-3β inhibitors

Catalytically Active Monomer of Glutathione S-Transferase Ï and Key Residues Involved in the Electrostatic Interaction between Subunits

Structure-based design leads to the identification of lithium mimetics that block mania-like effects in rodents. possible new GSK-3beta therapies for bipolar disorders

A Metabolite of Equine Estrogens, 4-Hydroxyequilenin, Induces DNA Damage and Apoptosis in Breast Cancer Cell Lines

Retention of Misfolded Mutant Transthyretin by the Chaperone BiP/GRP78 Mitigates Amyloidogenesi

Use of Molecular Modelling, Docking, and 3D-QSAR Studies for the Determination of the Binding Mode of 3-Benzofuranyl-4-indolyl-maleimides as GSK-3β Inhibitors

The SANT2 Domain of the Murine Tumor Cell DnaJ-like Protein 1 Human Homologue Interacts with Î±1-Antichymotrypsin and Kinetically Interferes with Its Serpin Inhibitory Activity

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