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Toxicology Strategies for Drug Discovery: Present and Future

Chemical research in toxicology, 2016-04, Vol.29 (4), p.473-504

2016

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Aldosterone induces a vascular inflammatory phenotype in the rat heart

American journal of physiology. Heart and circulatory physiology, 2002-11, Vol.283 (5), p.H1802-H1810

2002

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Comparison of RNA-Seq and Microarray Gene Expression Platforms for the Toxicogenomic Evaluation of Liver From Short-Term Rat Toxicity Studies

Frontiers in genetics, 2019-01, Vol.9, p.636-636

2019

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A human immunodeficiency virus protease inhibitor is a novel functional inhibitor of human pregnane X receptor

Drug metabolism and disposition, 2008-03, Vol.36 (3), p.500

2008

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Trovafloxacin-induced gene expression changes in liver-derived in vitro systems: comparison of primary human hepatocytes to HepG2 cells

Drug metabolism and disposition, 2008-02, Vol.36 (2), p.223

2008

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Identification of VEGF Signaling Inhibition-Induced Glomerular Injury in Rats through Site-Specific Urinary Biomarkers

International journal of molecular sciences, 2021-11, Vol.22 (23), p.12629

2021

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Novel Computational Approach to Predict Off-Target Interactions for Small Molecules

Frontiers in big data, 2019-07, Vol.2, p.25

2019

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Preclinical species gene expression database: Development and meta-analysis

Frontiers in genetics, 2023-01, Vol.13, p.1078050-1078050

2023

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N-vinylpyrrolidone dimer, a novel formulation excipient, causes hepatic and thyroid hypertrophy through the induction of hepatic microsomal enzymes in rats

Toxicology letters, 2012-01, Vol.208 (1), p.82-91

2012

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Comparison of immunohistochemistry for activated caspase-3 and cleaved cytokeratin 18 with the TUNEL method for quantification of apoptosis in histological sections of PC-3 subcutaneous xenografts

The Journal of pathology, 2003-02, Vol.199 (2), p.221-228

2003

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Microarray analysis of lipopolysaccharide potentiation of trovafloxacin-induced liver injury in rats suggests a role for proinflammatory chemokines and neutrophils

The Journal of pharmacology and experimental therapeutics, 2006-03, Vol.316 (3), p.1080

2006

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Acute Molecular Markers of Rodent Hepatic Carcinogenesis Identified by Transcription Profiling

Chemical research in toxicology, 2004-04, Vol.17 (4), p.463-470

2004

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Acyl glucuronide metabolites: Implications for drug safety assessment

Toxicology letters, 2017-04, Vol.272, p.1-7

2017

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Toxicogenomics Approaches to Address Toxicity and Carcinogenicity in the Liver

Toxicologic pathology, 2023-10, Vol.51 (7-8), p.470-481

2023

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Potential functional and pathological side effects related to off-target pharmacological activity

Journal of pharmacological and toxicological methods, 2017-09, Vol.87, p.108-126

2017

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Gene expression profiles in livers from diclofenac-treated rats reveal intestinal bacteria-dependent and -independent pathways associated with liver injury

The Journal of pharmacology and experimental therapeutics, 2008-12, Vol.327 (3), p.634

2008

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Assessing renal function: Some significant improvements on the horizon

The veterinary journal (1997), 2011-05, Vol.188 (2), p.128-129

2011

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Use of toxicogenomics to understand mechanisms of drug-induced hepatotoxicity during drug discovery and development

Toxicology letters, 2009-04, Vol.186 (1), p.22-31

2009

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Aldosterone/salt induces renal inflammation and fibrosis in hypertensive rats

Kidney international, 2003-05, Vol.63 (5), p.1791-1800

2003

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Off-target pharmacological activity at various kinases: Potential functional and pathological side effects

Journal of pharmacological and toxicological methods, 2023-09, Vol.123, p.107468-107468, Article 107468

2023

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Comparison of TNFα to lipopolysaccharide as an inflammagen to characterize the idiosyncratic hepatotoxicity potential of drugs: Trovafloxacin as an example

International journal of molecular sciences, 2010-11, Vol.11 (11), p.4697-4714

2010

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Global transcriptomic profiling using small volumes of whole blood: a cost-effective method for translational genomic biomarker identification in small animals

International journal of molecular sciences, 2011-04, Vol.12 (4), p.2502-2517

2011

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Role of cytochrome P450c17α in dibromoacetic acid-induced testicular toxicity in rats

Archives of toxicology, 2011-05, Vol.85 (5), p.513-523

2011

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Transgenic Model of Aldosterone-Driven Cardiac Hypertrophy and Heart Failure

Circulation research, 2003-07, Vol.93 (1), p.69-76

2003

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Use of toxicogenomics in drug safety evaluation: Current status and an industry perspective

Regulatory toxicology and pharmacology, 2018-07, Vol.96, p.18-29

2018

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Toxicology Strategies for Drug Discovery: Present and Future

Aldosterone induces a vascular inflammatory phenotype in the rat heart

Comparison of RNA-Seq and Microarray Gene Expression Platforms for the Toxicogenomic Evaluation of Liver From Short-Term Rat Toxicity Studies

A human immunodeficiency virus protease inhibitor is a novel functional inhibitor of human pregnane X receptor

Trovafloxacin-induced gene expression changes in liver-derived in vitro systems: comparison of primary human hepatocytes to HepG2 cells

Identification of VEGF Signaling Inhibition-Induced Glomerular Injury in Rats through Site-Specific Urinary Biomarkers

Novel Computational Approach to Predict Off-Target Interactions for Small Molecules

Preclinical species gene expression database: Development and meta-analysis

N-vinylpyrrolidone dimer, a novel formulation excipient, causes hepatic and thyroid hypertrophy through the induction of hepatic microsomal enzymes in rats

Comparison of immunohistochemistry for activated caspase-3 and cleaved cytokeratin 18 with the TUNEL method for quantification of apoptosis in histological sections of PC-3 subcutaneous xenografts

Microarray analysis of lipopolysaccharide potentiation of trovafloxacin-induced liver injury in rats suggests a role for proinflammatory chemokines and neutrophils

Acute Molecular Markers of Rodent Hepatic Carcinogenesis Identified by Transcription Profiling

Acyl glucuronide metabolites: Implications for drug safety assessment

Toxicogenomics Approaches to Address Toxicity and Carcinogenicity in the Liver

Potential functional and pathological side effects related to off-target pharmacological activity

Gene expression profiles in livers from diclofenac-treated rats reveal intestinal bacteria-dependent and -independent pathways associated with liver injury

Assessing renal function: Some significant improvements on the horizon

Use of toxicogenomics to understand mechanisms of drug-induced hepatotoxicity during drug discovery and development

Aldosterone/salt induces renal inflammation and fibrosis in hypertensive rats

Off-target pharmacological activity at various kinases: Potential functional and pathological side effects

Comparison of TNFα to lipopolysaccharide as an inflammagen to characterize the idiosyncratic hepatotoxicity potential of drugs: Trovafloxacin as an example

Global transcriptomic profiling using small volumes of whole blood: a cost-effective method for translational genomic biomarker identification in small animals

Role of cytochrome P450c17α in dibromoacetic acid-induced testicular toxicity in rats

Transgenic Model of Aldosterone-Driven Cardiac Hypertrophy and Heart Failure

Use of toxicogenomics in drug safety evaluation: Current status and an industry perspective

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