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The pump, the exchanger, and the holy spirit: origins and 40-year evolution of ideas about the ouabain-Na + pump endocrine system

American Journal of Physiology: Cell Physiology, 2018-01, Vol.314 (1), p.C3-C26

Blaustein, Mordecai P

2018

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How does pressure overload cause cardiac hypertrophy and dysfunction? High-ouabain affinity cardiac Na + pumps are crucial

American journal of physiology. Heart and circulatory physiology, 2017-11, Vol.313 (5), p.H919-H930

Blaustein, Mordecai P

2017

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How NaCl raises blood pressure: a new paradigm for the pathogenesis of salt-dependent hypertension

American journal of physiology. Heart and circulatory physiology, 2012-03, Vol.302 (5), p.H1031-H1049

2012

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Na+/Ca2+ exchange and Na+/K+‐ATPase in the heart

The Journal of physiology, 2015-03, Vol.593 (6), p.1361-1382

2015

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Central and peripheral slow-pressor mechanisms contributing to Angiotensin II-salt hypertension in rats

Cardiovascular research, 2018-02, Vol.114 (2), p.233-246

2018

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Sodium/Calcium Exchange: Its Physiological Implications

Physiological reviews, 1999-07, Vol.79 (3), p.763-854

1999

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Neuroendocrine humoral and vascular components in the pressor pathway for brain angiotensin II: a new axis in long term blood pressure control

PloS one, 2014-10, Vol.9 (9), p.e108916-e108916

2014

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Preparation of primary cultured mesenteric artery smooth muscle cells for fluorescent imaging and physiological studies

Nature protocols, 2007-01, Vol.1 (6), p.2681-2687

2007

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Ouabain, endogenous ouabain and ouabain-like factors: The Na+ pump/ouabain receptor, its linkage to NCX, and its myriad functions

Cell calcium (Edinburgh), 2020-03, Vol.86, p.102159-102159, Article 102159

2020

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Sensational site: the sodium pump ouabain-binding site and its ligands

American Journal of Physiology: Cell Physiology, 2024-04, Vol.326 (4), p.C1120

2024

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Evolution of our understanding of cell volume regulation by the pump-leak mechanism

The Journal of general physiology, 2019-04, Vol.151 (4), p.407-416

2019

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Endogenous Ouabain: Recent Advances and Controversies

Hypertension (Dallas, Tex. 1979), 2016-09, Vol.68 (3), p.526-532

2016

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Why isn't endogenous ouabain more widely accepted?

American journal of physiology. Heart and circulatory physiology, 2014-09, Vol.307 (5), p.H635-H639

Blaustein, Mordecai P

2014

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Reply to "Letter to the editor: Comments on Blaustein (2018): 'The pump, the exchanger, and the holy spirit: origins and 40-year evolution of ideas about the ouabain-Na + pump endocrine system'"

American Journal of Physiology: Cell Physiology, 2018-05, Vol.314 (5), p.C641-C642

Blaustein, Mordecai P

2018

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Upregulation of Na+ and Ca2+ transporters in arterial smooth muscle from ouabain-induced hypertensive rats

American journal of physiology. Heart and circulatory physiology, 2010-01, Vol.298 (1), p.H263-H274

2010

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Increased arterial smooth muscle Ca2+ signaling, vasoconstriction, and myogenic reactivity in Milan hypertensive rats

American journal of physiology. Heart and circulatory physiology, 2012-02, Vol.302 (3), p.H611-H620

2012

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Sodium pump α2 subunits control myogenic tone and blood pressure in mice

The Journal of physiology, 2005-11, Vol.569 (1), p.243-256

2005

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Knockout of Na+/Ca2+ exchanger in smooth muscle attenuates vasoconstriction and L-type Ca2+ channel current and lowers blood pressure

American journal of physiology. Heart and circulatory physiology, 2010-05, Vol.298 (5), p.H1472-H1483

2010

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Local Subplasma Membrane Ca²⁺ Signals Detected by a Tethered Ca²⁺ Sensor

Proceedings of the National Academy of Sciences - PNAS, 2006-08, Vol.103 (35), p.13232-13237

2006

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Letter to the Editor concerning Baecher et al. (Clin Chim Acta 2014;431:87–92)

Clinica chimica acta, 2015-08, Vol.448, p.248-249

Blaustein, Mordecai P.

2015

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Plasma Membrane-Cytoskeleton-Endoplasmic Reticulum Complexes in Neurons and Astrocytes

The Journal of biological chemistry, 2004-01, Vol.279 (4), p.2885-2893

2004

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Na+ Pump Low and High Ouabain Affinity α Subunit Isoforms are Differently Distributed in Cells

Proceedings of the National Academy of Sciences - PNAS, 1997-03, Vol.94 (5), p.1800-1805

1997

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In vivo assessment of artery smooth muscle [Ca2+]i and MLCK activation in FRET-based biosensor mice

American journal of physiology. Heart and circulatory physiology, 2010-09, Vol.299 (3), p.H946-H956

2010

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Multipurpose Na+ ions mediate excitation and cellular homeostasis: Evolution of the concept of Na+ pumps and Na+/Ca2+ exchangers

Cell calcium (Edinburgh), 2020-05, Vol.87, p.102166, Article 102166

2020

Volltextzugriff (PDF)

Attenuated renal vascular responses to acute angiotensin II infusion in smooth muscle-specific Na+/Ca2+ exchanger knockout mice

American journal of physiology. Renal physiology, 2011-09, Vol.301 (3), p.F574-F579

2011

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The pump, the exchanger, and the holy spirit: origins and 40-year evolution of ideas about the ouabain-Na + pump endocrine system

How does pressure overload cause cardiac hypertrophy and dysfunction? High-ouabain affinity cardiac Na + pumps are crucial

How NaCl raises blood pressure: a new paradigm for the pathogenesis of salt-dependent hypertension

Na+/Ca2+ exchange and Na+/K+‐ATPase in the heart

Central and peripheral slow-pressor mechanisms contributing to Angiotensin II-salt hypertension in rats

Sodium/Calcium Exchange: Its Physiological Implications

Neuroendocrine humoral and vascular components in the pressor pathway for brain angiotensin II: a new axis in long term blood pressure control

Preparation of primary cultured mesenteric artery smooth muscle cells for fluorescent imaging and physiological studies

Ouabain, endogenous ouabain and ouabain-like factors: The Na+ pump/ouabain receptor, its linkage to NCX, and its myriad functions

Sensational site: the sodium pump ouabain-binding site and its ligands

Evolution of our understanding of cell volume regulation by the pump-leak mechanism

Endogenous Ouabain: Recent Advances and Controversies

Why isn't endogenous ouabain more widely accepted?

Reply to "Letter to the editor: Comments on Blaustein (2018): 'The pump, the exchanger, and the holy spirit: origins and 40-year evolution of ideas about the ouabain-Na + pump endocrine system'"

Upregulation of Na+ and Ca2+ transporters in arterial smooth muscle from ouabain-induced hypertensive rats

Increased arterial smooth muscle Ca2+ signaling, vasoconstriction, and myogenic reactivity in Milan hypertensive rats

Sodium pump α2 subunits control myogenic tone and blood pressure in mice

Knockout of Na+/Ca2+ exchanger in smooth muscle attenuates vasoconstriction and L-type Ca2+ channel current and lowers blood pressure

Local Subplasma Membrane Ca²⁺ Signals Detected by a Tethered Ca²⁺ Sensor

Letter to the Editor concerning Baecher et al. (Clin Chim Acta 2014;431:87–92)

Plasma Membrane-Cytoskeleton-Endoplasmic Reticulum Complexes in Neurons and Astrocytes

Na+ Pump Low and High Ouabain Affinity α Subunit Isoforms are Differently Distributed in Cells

In vivo assessment of artery smooth muscle [Ca2+]i and MLCK activation in FRET-based biosensor mice

Multipurpose Na+ ions mediate excitation and cellular homeostasis: Evolution of the concept of Na+ pumps and Na+/Ca2+ exchangers

Attenuated renal vascular responses to acute angiotensin II infusion in smooth muscle-specific Na+/Ca2+ exchanger knockout mice

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