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Novel DNA Damage Checkpoints Mediating Cell Death Induced by the NEDD8-Activating Enzyme Inhibitor MLN4924

Cancer research (Chicago, Ill.), 2013, Vol.73 (1), p.225-234

2013

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Quantitative Proteomic Analysis of Cellular Protein Modulation upon Inhibition of the NEDD8-Activating Enzyme by MLN4924

Molecular & cellular proteomics, 2011-11, Vol.10 (11), p.M111.009183-M111.009183, Article M111.009183

2011

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Genome-Wide siRNA Screen for Modulators of Cell Death Induced by Proteasome Inhibitor Bortezomib

Cancer research (Chicago, Ill.), 2010-06, Vol.70 (11), p.4318-4326

2010

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p38 Mitogen-activated protein kinase mediates cell death and p21-activated kinase mediates cell survival during chemotherapeutic drug-induced mitotic arrest

Molecular biology of the cell, 2003-05, Vol.14 (5), p.2071-2087

2003

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The JAMM motif of human deubiquitinase Poh1 is essential for cell viability

Molecular cancer therapeutics, 2007-01, Vol.6 (1), p.262-268

2007

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Cloning of a Novel Mitogen-activated Protein Kinase Kinase Kinase, MEKK4, That Selectively Regulates the c-Jun Amino Terminal Kinase Pathway

The Journal of biological chemistry, 1997-03, Vol.272 (13), p.8288-8295

1997

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Comparison of biochemical and biological effects of ML858 (salinosporamide A) and bortezomib

Molecular cancer therapeutics, 2006-12, Vol.5 (12), p.3052-3061

2006

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Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S β5-subunit

Biochemical journal, 2010-09, Vol.430 (3), p.461-476

2010

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The ups and downs of MEK kinase interactions

Cellular Signalling, 2001-12, Vol.13 (12), p.863-875

2001

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A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK

Nature cell biology, 2002-11, Vol.4 (11), p.901-906

2002

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Nedd8-activating enzyme inhibitor MLN4924 provides synergy with mitomycin C through interactions with ATR, BRCA1/BRCA2, and chromatin dynamics pathways

Molecular cancer therapeutics, 2014-06, Vol.13 (6), p.1625-1635

2014

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Interferon-γ-induced upregulation of immunoproteasome subunit assembly overcomes bortezomib resistance in human hematological cell lines

Journal of hematology and oncology, 2014-01, Vol.7 (1), p.7-7, Article 7

2014

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Human adenosine A1 receptor and P2Y2‐purinoceptor‐mediated activation of the mitogen‐activated protein kinase cascade in transfected CHO cells

British journal of pharmacology, 1998-08, Vol.124 (7), p.1491-1499

1998

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Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome

Bioorganic & medicinal chemistry letters, 2010-11, Vol.20 (22), p.6581-6586

2010

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Group‐I metabotropic glutamate receptors, mGlu1a and mGlu5a, couple to extracellular signal‐regulated kinase (ERK) activation via distinct, but overlapping, signalling pathways

Journal of neurochemistry, 2002-12, Vol.83 (5), p.1139-1153

2002

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MEK Kinase 3 Directly Activates MKK6 and MKK7, Specific Activators of the p38 and c-Jun NH2-terminal Kinases

The Journal of biological chemistry, 1999-06, Vol.274 (23), p.16604-16610

1999

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MEKK3 interacts with the PA28 gamma regulatory subunit of the proteasome

Biochemical journal, 2003-07, Vol.373 (Pt 1), p.71-79

2003

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Pharmacodynamic monitoring of (immuno)proteasome inhibition during bortezomib treatment of a critically ill patient with lupus nephritis and myocarditis

Lupus science & medicine, 2015-01, Vol.2 (1), p.e000121-e000121

2015

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Phospholipase C-β1 is a GTPase-activating protein for Gq/11, its physiologic regulator

Cell, 1992-08, Vol.70 (3), p.411-418

1992

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A Region of Adenylyl Cyclase 2 Critical for Regulation by G Protein βγ Subunits

Science (American Association for the Advancement of Science), 1995-05, Vol.268 (5214), p.1166-1169

1995

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Evidence for cross‐talk between M 2 and M 3 muscarinic acetylcholine receptors in the regulation of second messenger and extracellular signal‐regulated kinase signalling pathways in Chinese hamster ovary cells

British journal of pharmacology, 2003-04, Vol.138 (7), p.1340-1350

2003

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Abstract C55: Nedd8-activating enzyme inhibitor pevonedistat synergizes with cisplatin and carboplatin through interference with nucleotide excision repair and interstrand cross-link repair mechanisms in non-small cell lung cancer

Molecular cancer therapeutics, 2015-12, Vol.14 (12_Supplement_2), p.C55-C55

2015

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Abstract C233: Activation of p53 by the NEDD8 activating enzyme inhibitor MLN4924 is independent of Cdt1 and involves the cullin-RING ligase CRL4-DTL

Molecular cancer therapeutics, 2013-11, Vol.12 (11_Supplement), p.C233-C233

2013

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Characterization of the Mitogen-activated Protein Kinase Kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 Pathways Regulated by MEK Kinases 2 and 3

The Journal of biological chemistry, 1997-05, Vol.272 (22), p.14489-14496

1997

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Human adenosine A 1 receptor and P2Y 2 ‐purinoceptor‐mediated activation of the mitogen‐activated protein kinase cascade in transfected CHO cells

British journal of pharmacology, 2009-02, Vol.124 (7), p.1491-1499

2009

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Novel DNA Damage Checkpoints Mediating Cell Death Induced by the NEDD8-Activating Enzyme Inhibitor MLN4924

Quantitative Proteomic Analysis of Cellular Protein Modulation upon Inhibition of the NEDD8-Activating Enzyme by MLN4924

Genome-Wide siRNA Screen for Modulators of Cell Death Induced by Proteasome Inhibitor Bortezomib

p38 Mitogen-activated protein kinase mediates cell death and p21-activated kinase mediates cell survival during chemotherapeutic drug-induced mitotic arrest

The JAMM motif of human deubiquitinase Poh1 is essential for cell viability

Cloning of a Novel Mitogen-activated Protein Kinase Kinase Kinase, MEKK4, That Selectively Regulates the c-Jun Amino Terminal Kinase Pathway

Comparison of biochemical and biological effects of ML858 (salinosporamide A) and bortezomib

Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S β5-subunit

The ups and downs of MEK kinase interactions

A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK

Nedd8-activating enzyme inhibitor MLN4924 provides synergy with mitomycin C through interactions with ATR, BRCA1/BRCA2, and chromatin dynamics pathways

Interferon-γ-induced upregulation of immunoproteasome subunit assembly overcomes bortezomib resistance in human hematological cell lines

Human adenosine A1 receptor and P2Y2‐purinoceptor‐mediated activation of the mitogen‐activated protein kinase cascade in transfected CHO cells

Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome

Group‐I metabotropic glutamate receptors, mGlu1a and mGlu5a, couple to extracellular signal‐regulated kinase (ERK) activation via distinct, but overlapping, signalling pathways

MEK Kinase 3 Directly Activates MKK6 and MKK7, Specific Activators of the p38 and c-Jun NH2-terminal Kinases

MEKK3 interacts with the PA28 gamma regulatory subunit of the proteasome

Pharmacodynamic monitoring of (immuno)proteasome inhibition during bortezomib treatment of a critically ill patient with lupus nephritis and myocarditis

Phospholipase C-β1 is a GTPase-activating protein for Gq/11, its physiologic regulator

A Region of Adenylyl Cyclase 2 Critical for Regulation by G Protein βγ Subunits

Evidence for cross‐talk between M 2 and M 3 muscarinic acetylcholine receptors in the regulation of second messenger and extracellular signal‐regulated kinase signalling pathways in Chinese hamster ovary cells

Abstract C55: Nedd8-activating enzyme inhibitor pevonedistat synergizes with cisplatin and carboplatin through interference with nucleotide excision repair and interstrand cross-link repair mechanisms in non-small cell lung cancer

Abstract C233: Activation of p53 by the NEDD8 activating enzyme inhibitor MLN4924 is independent of Cdt1 and involves the cullin-RING ligase CRL4-DTL

Characterization of the Mitogen-activated Protein Kinase Kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 Pathways Regulated by MEK Kinases 2 and 3

Human adenosine A 1 receptor and P2Y 2 ‐purinoceptor‐mediated activation of the mitogen‐activated protein kinase cascade in transfected CHO cells

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