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HIV capsid is a tractable target for small molecule therapeutic intervention

PLoS pathogens, 2010-12, Vol.6 (12), p.e1001220

2010

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HIV envelope antibodies and TLR7 agonist partially prevent viral rebound in chronically SHIV-infected monkeys

PLoS pathogens, 2022-04, Vol.18 (4), p.e1010467-e1010467

2022

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A restricted role for TYK2 catalytic activity in human cytokine responses revealed by novel TYK2-selective inhibitors

The Journal of immunology (1950), 2013-09, Vol.191 (5), p.2205-2216

2013

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A broadly neutralizing human monoclonal antibody directed against a novel conserved epitope on the influenza virus H3 hemagglutinin globular head

Journal of virology, 2014-06, Vol.88 (12), p.6743-6750

2014

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Lead identification of novel and selective TYK2 inhibitors

European journal of medicinal chemistry, 2013-09, Vol.67 (C), p.175-187

2013

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Discovery of Potent and Selective Pyrazolopyrimidine Janus Kinase 2 Inhibitors

Journal of medicinal chemistry, 2012-11, Vol.55 (22), p.10090-10107

2012

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New Small-Molecule Inhibitor Class Targeting Human Immunodeficiency Virus Type 1 Virion Maturation

Antimicrobial Agents and Chemotherapy, 2009-12, Vol.53 (12), p.5080-5087

2009

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Inhibitors of HIV-1 attachment. Part 4: A study of the effect of piperazine substitution patterns on antiviral potency in the context of indole-based derivatives

Bioorganic & medicinal chemistry letters, 2009-09, Vol.19 (17), p.5140-5145

2009

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Inhibitors of HIV-1 attachment. Part 2: An initial survey of indole substitution patterns

Bioorganic & medicinal chemistry letters, 2009-04, Vol.19 (7), p.1977-1981

2009

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Inhibitors of HIV-1 attachment. Part 3: A preliminary survey of the effect of structural variation of the benzamide moiety on antiviral activity

Bioorganic & medicinal chemistry letters, 2009-09, Vol.19 (17), p.5136-5139

2009

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BMS-232632, a Highly Potent Human Immunodeficiency Virus Protease Inhibitor That Can Be Used in Combination with Other Available Antiretroviral Agents

Antimicrobial Agents and Chemotherapy, 2000-08, Vol.44 (8), p.2093-2099

2000

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High-Throughput Human Immunodeficiency Virus Type 1 (HIV-1) Full Replication Assay That Includes HIV-1 Vif as an Antiviral Target

Antimicrobial Agents and Chemotherapy, 2005-09, Vol.49 (9), p.3833-3841

2005

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A survey of core replacements in indole-based HIV-1 attachment inhibitors

Bioorganic & medicinal chemistry letters, 2019-06, Vol.29 (11), p.1423-1429

2019

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Compensatory substitutions in the HIV-1 capsid reduce the fitness cost associated with resistance to a capsid-targeting small-molecule inhibitor

Journal of virology, 2015-01, Vol.89 (1), p.208-219

2015

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Identification and Characterization of UK-201844, a Novel Inhibitor That Interferes with Human Immunodeficiency Virus Type 1 gp160 Processing

Antimicrobial Agents and Chemotherapy, 2007-10, Vol.51 (10), p.3554-3561

2007

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Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model

Bioorganic & medicinal chemistry letters, 2017-09, Vol.27 (18), p.4370-4376

2017

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A novel HIV-1 antiviral high throughput screening approach for the discovery of HIV-1 inhibitors

Antiviral research, 2005-02, Vol.65 (2), p.107-116

2005

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HIV-1 entry – an expanding portal for drug discovery

Drug Discovery Today, 2000-05, Vol.5 (5), p.183-194

2000

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Identification of C‑2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2

Journal of medicinal chemistry, 2013-06, Vol.56 (11), p.4764-4785

2013

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2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitors

Bioorganic & medicinal chemistry letters, 2013-09, Vol.23 (17), p.5014-5021

2013

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Discovery and Optimization of C-2 Methyl Imidazopyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2

Journal of medicinal chemistry, 2012-07, Vol.55 (13), p.6176-6193

2012

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Discovery of 4-Benzoyl-1-[(4-methoxy-1H- pyrrolo[2,3-b]pyridin-3-yl)oxoacetyl]-2- (R)-methylpiperazine (BMS-378806): A Novel HIV-1 Attachment Inhibitor That Interferes with CD4-gp120 Interactions

Journal of medicinal chemistry, 2003-09, Vol.46 (20), p.4236-4239

2003

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Design and evaluation of novel 8-oxo-pyridopyrimidine Jak1/2 inhibitors

Bioorganic & medicinal chemistry letters, 2013-11, Vol.23 (21), p.5923-5930

2013

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Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1

Bioorganic & medicinal chemistry letters, 2013-06, Vol.23 (12), p.3592-3598

2013

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Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2

Bioorganic & medicinal chemistry letters, 2012-12, Vol.22 (24), p.7627-7633

2012

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HIV capsid is a tractable target for small molecule therapeutic intervention

HIV envelope antibodies and TLR7 agonist partially prevent viral rebound in chronically SHIV-infected monkeys

A restricted role for TYK2 catalytic activity in human cytokine responses revealed by novel TYK2-selective inhibitors

A broadly neutralizing human monoclonal antibody directed against a novel conserved epitope on the influenza virus H3 hemagglutinin globular head

Lead identification of novel and selective TYK2 inhibitors

Discovery of Potent and Selective Pyrazolopyrimidine Janus Kinase 2 Inhibitors

New Small-Molecule Inhibitor Class Targeting Human Immunodeficiency Virus Type 1 Virion Maturation

Inhibitors of HIV-1 attachment. Part 4: A study of the effect of piperazine substitution patterns on antiviral potency in the context of indole-based derivatives

Inhibitors of HIV-1 attachment. Part 2: An initial survey of indole substitution patterns

Inhibitors of HIV-1 attachment. Part 3: A preliminary survey of the effect of structural variation of the benzamide moiety on antiviral activity

BMS-232632, a Highly Potent Human Immunodeficiency Virus Protease Inhibitor That Can Be Used in Combination with Other Available Antiretroviral Agents

High-Throughput Human Immunodeficiency Virus Type 1 (HIV-1) Full Replication Assay That Includes HIV-1 Vif as an Antiviral Target

A survey of core replacements in indole-based HIV-1 attachment inhibitors

Compensatory substitutions in the HIV-1 capsid reduce the fitness cost associated with resistance to a capsid-targeting small-molecule inhibitor

Identification and Characterization of UK-201844, a Novel Inhibitor That Interferes with Human Immunodeficiency Virus Type 1 gp160 Processing

Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model

A novel HIV-1 antiviral high throughput screening approach for the discovery of HIV-1 inhibitors

HIV-1 entry – an expanding portal for drug discovery

Identification of C‑2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2

2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitors

Discovery and Optimization of C-2 Methyl Imidazopyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2

Discovery of 4-Benzoyl-1-[(4-methoxy-1H- pyrrolo[2,3-b]pyridin-3-yl)oxoacetyl]-2- (R)-methylpiperazine (BMS-378806): A Novel HIV-1 Attachment Inhibitor That Interferes with CD4-gp120 Interactions

Design and evaluation of novel 8-oxo-pyridopyrimidine Jak1/2 inhibitors

Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1

Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2

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