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EMD 1214063 and EMD 1204831 Constitute a New Class of Potent and Highly Selective c-Met Inhibitors

Clinical cancer research, 2013-06, Vol.19 (11), p.2941-2951

2013

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Insulin-Like Growth Factor-1 Receptor Inhibition Induces a Resistance Mechanism via the Epidermal Growth Factor Receptor/HER3/AKT Signaling Pathway: Rational Basis for Cotargeting Insulin-Like Growth Factor-1 Receptor and Epidermal Growth Factor Receptor in Hepatocellular Carcinoma

Clinical cancer research, 2009-09, Vol.15 (17), p.5445-5456

2009

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The c-Met Inhibitor MSC2156119J Effectively Inhibits Tumor Growth in Liver Cancer Models

Cancers, 2014-08, Vol.6 (3), p.1736-1752

2014

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Protective autophagy is involved in resistance towards MET inhibitors in human gastric adenocarcinoma cells

Biochemical and biophysical research communications, 2013-02, Vol.431 (2), p.264-269

2013

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Nck adaptor proteins control the organization of neuronal circuits important for walking

Proceedings of the National Academy of Sciences - PNAS, 2007-12, Vol.104 (52), p.20973-20978

2007

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Enteropathogenic E. coli Tir binds Nck to initiate actin pedestal formation in host cells

Nature cell biology, 2001-09, Vol.3 (9), p.856-859

2001

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KRAS and HRAS mutations confer resistance to MET targeting in preclinical models of MET-expressing tumor cells

Molecular oncology, 2015-08, Vol.9 (7), p.1434-1446

2015

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The Murine Nck SH2/SH3 Adaptors Are Important for the Development of Mesoderm-Derived Embryonic Structures and for Regulating the Cellular Actin Network

Molecular and Cellular Biology, 2003-07, Vol.23 (13), p.4586-4597

2003

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Scatter factor/hepatocyte growth factor is essential for liver development

Nature (London), 1995-02, Vol.373 (6516), p.699-702

1995

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The role of SF/HGF and c-Met in the development of skeletal muscle

Development (Cambridge), 1999-04, Vol.126 (8), p.1621-1629

1999

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Nck adaptors are positive regulators of the size and sensitivity of the T-cell repertoire

Proceedings of the National Academy of Sciences - PNAS, 2010-08, Vol.107 (35), p.15529-15534

2010

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Hepatocyte Growth Factor/Scatter Factor Is an Axonal Chemoattractant and a Neurotrophic Factor for Spinal Motor Neurons

Neuron (Cambridge, Mass.), 1996-12, Vol.17 (6), p.1157-1172

1996

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The branchial arches and HGF are growth-promoting and chemoattractant for cranial motor axons

Development (Cambridge), 2000-04, Vol.127 (8), p.1751-1766

2000

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Epidermolysis Bullosa and Embryonic Lethality in Mice Lacking the Multi-PDZ Domain Protein GRIP1

Proceedings of the National Academy of Sciences - PNAS, 2002-05, Vol.99 (10), p.6816-6821

2002

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Abstract 4663: Combination of c-Met inhibitor tepotinib (MSC2156119J) and a third-generation EGFR inhibitor can overcome double resistance mediated by EGFR T790M mutation and c-Met amplification in non-small cell lung cancer models

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.4663-4663

2016

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First-in-Man Phase I Trial of the Selective MET Inhibitor Tepotinib in Patients with Advanced Solid Tumors

Clinical cancer research, 2020-03, Vol.26 (6), p.1237-1246

2020

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Abstract 2591: Activity of MSC2156119J in non-small cell lung cancer models with activating EGFR mutation

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.2591-2591

2015

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The selective c-Met inhibitor tepotinib can overcome epidermal growth factor receptor inhibitor resistance mediated by aberrant c-Met activation in NSCLC models

American journal of cancer research, 2017-01, Vol.7 (4), p.962-972

2017

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A Humanized Anti-IGF-1R Monoclonal Antibody (AVE1642) Synergizes with Bortezomib To Induce Apoptosis in CD45neg Myeloma Cells

Blood, 2006-11, Vol.108 (11), p.845-845

2006

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Identification and optimization of pyridazinones as potent and selective c-Met kinase inhibitors

Bioorganic & medicinal chemistry letters, 2015-04, Vol.25 (7), p.1597-1602

2015

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Depletion of FOXM1 via MET Targeting Underlies Establishment of a DNA Damage-Induced Senescence Program in Gastric Cancer

Clinical cancer research, 2016-11, Vol.22 (21), p.5322-5336

2016

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Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes

Nature, 2006-04, Vol.440 (7085), p.818-823

2006

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227 Th-Labeled Anti-CD22 Antibody (BAY 1862864) in Relapsed/Refractory CD22-Positive Non-Hodgkin Lymphoma: A First-in-Human, Phase I Study

Cancer biotherapy & radiopharmaceuticals, 2021-10, Vol.36 (8), p.672

2021

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Essential role for the c- met receptor in the migration of myogenic precursor cells into the limb bud

Nature (London), 1995-08, Vol.376 (6543), p.768-771

1995

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EMD 1214063 and EMD 1204831 Constitute a New Class of Potent and Highly Selective c-Met Inhibitors

Insulin-Like Growth Factor-1 Receptor Inhibition Induces a Resistance Mechanism via the Epidermal Growth Factor Receptor/HER3/AKT Signaling Pathway: Rational Basis for Cotargeting Insulin-Like Growth Factor-1 Receptor and Epidermal Growth Factor Receptor in Hepatocellular Carcinoma

The c-Met Inhibitor MSC2156119J Effectively Inhibits Tumor Growth in Liver Cancer Models

Protective autophagy is involved in resistance towards MET inhibitors in human gastric adenocarcinoma cells

Nck adaptor proteins control the organization of neuronal circuits important for walking

Enteropathogenic E. coli Tir binds Nck to initiate actin pedestal formation in host cells

KRAS and HRAS mutations confer resistance to MET targeting in preclinical models of MET-expressing tumor cells

The Murine Nck SH2/SH3 Adaptors Are Important for the Development of Mesoderm-Derived Embryonic Structures and for Regulating the Cellular Actin Network

Scatter factor/hepatocyte growth factor is essential for liver development

The role of SF/HGF and c-Met in the development of skeletal muscle

Nck adaptors are positive regulators of the size and sensitivity of the T-cell repertoire

Hepatocyte Growth Factor/Scatter Factor Is an Axonal Chemoattractant and a Neurotrophic Factor for Spinal Motor Neurons

The branchial arches and HGF are growth-promoting and chemoattractant for cranial motor axons

Epidermolysis Bullosa and Embryonic Lethality in Mice Lacking the Multi-PDZ Domain Protein GRIP1

Abstract 4663: Combination of c-Met inhibitor tepotinib (MSC2156119J) and a third-generation EGFR inhibitor can overcome double resistance mediated by EGFR T790M mutation and c-Met amplification in non-small cell lung cancer models

First-in-Human Trial of the Oral Ataxia Telangiectasia and RAD3-Related (ATR) Inhibitor BAY 1895344 in Patients with Advanced Solid Tumors

First-in-Man Phase I Trial of the Selective MET Inhibitor Tepotinib in Patients with Advanced Solid Tumors

Abstract 2591: Activity of MSC2156119J in non-small cell lung cancer models with activating EGFR mutation

The selective c-Met inhibitor tepotinib can overcome epidermal growth factor receptor inhibitor resistance mediated by aberrant c-Met activation in NSCLC models

A Humanized Anti-IGF-1R Monoclonal Antibody (AVE1642) Synergizes with Bortezomib To Induce Apoptosis in CD45neg Myeloma Cells

Identification and optimization of pyridazinones as potent and selective c-Met kinase inhibitors

Depletion of FOXM1 via MET Targeting Underlies Establishment of a DNA Damage-Induced Senescence Program in Gastric Cancer

Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes

227 Th-Labeled Anti-CD22 Antibody (BAY 1862864) in Relapsed/Refractory CD22-Positive Non-Hodgkin Lymphoma: A First-in-Human, Phase I Study

Essential role for the c- met receptor in the migration of myogenic precursor cells into the limb bud

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