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APX005M, a CD40 agonist antibody with unique epitope specificity and Fc receptor binding profile for optimal therapeutic application

Cancer Immunology, Immunotherapy, 2021-07, Vol.70 (7), p.1853-1865

2021

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Isolation and characterization of plasmacytoid dendritic cells from Flt3 ligand and granulocyte-macrophage colony-stimulating factor–treated mice

Blood, 2001-12, Vol.98 (13), p.3520-3526

Björck, Pia

2001

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Influenza A virus elevates active cathepsin B in primary murine DC

International immunology, 2007-05, Vol.19 (5), p.645-655

2007

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CD40 ligation counteracts Fas-induced apoptosis of human dendritic cells

International immunology, 1997-03, Vol.9 (3), p.365-372

1997

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Abstract 5546: A murine reactive version of TAK-573 (anti-CD38 attenuated IFNα fusion protein) shows immunomodulatory and antitumor activity, alone and in combination with standard-of-care agents, in IFNa-insensitive, immunocompetent murine multiple myeloma tumor models

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.5546-5546

2020

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Plasmacytoid Dendritic Cells Take Up Opsonized Antigen Leading to CD4+ and CD8+ T Cell Activation In Vivo

The Journal of immunology (1950), 2008-09, Vol.181 (6), p.3811-3817

2008

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Dendritic cells exposed to herpes simplex virus in vivo do not produce IFN-alpha after rechallenge with virus in vitro and exhibit decreased T cell alloreactivity

The Journal of immunology (1950), 2004-05, Vol.172 (9), p.5396-5404

Bjoerck, Pia

2004

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A murine reactive version of TAK-573 (anti-CD38-targeted attenuated IFNα fusion protein) shows immunomodulatory and

Clinical lymphoma, myeloma and leukemia, 2019-10, Vol.19 (10), p.e116-e117

2019

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Cutting Edge: CD19+ Pro-B Cells Can Give Rise to Dendritic Cells In Vitro

The Journal of immunology (1950), 1998-12, Vol.161 (11), p.5795-5799

1998

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TAK-573, an anti-CD38-targeted attenuated interferon alpha (IFNα) fusion protein, showed anti-myeloma tumor responses in combination with standard of care (SOC) agents in multiple myeloma (MM) xenograft tumor models in vivo

Clinical lymphoma, myeloma and leukemia, 2019-10, Vol.19 (10), p.e116-e116

2019

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The CD40 agonistic monoclonal antibody APX005M has potent immune stimulatory capabilities

Journal for immunotherapy of cancer, 2015-11, Vol.3 (Suppl 2), p.P198-P198

2015

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ITOC2 – 011. Identification of second-generation potent and selective inhibitors of indoleamine-2,3-dioxygenase-1 (IDO1) for the treatment of cancer

European journal of cancer (1990), 2015-03, Vol.51, p.S4-S4

2015

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Human Interdigitating Dendritic Cells Induce Isotype Switching and IL-13-Dependent IgM Production in CD40-Activated Naive B Cells

The Journal of immunology (1950), 2000-02, Vol.164 (4), p.1847-1854

2000

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Plasmacytoid dendritic cell dichotomy: identification of IFN-α producing cells as a phenotypically and functionally distinct subset

The Journal of immunology (1950), 2011-02, Vol.186 (3), p.1477-1485

2011

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Abstract 5004: APX005M, a humanized anti-CD40 antibody with strong immune-modulatory activities capable of tumor eradication in vivo

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.5004-5004

2016

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Human interdigitating dendritic cells directly stimulate CD40‐activated naive B cells

European journal of immunology, 1997-05, Vol.27 (5), p.1266-1274

1997

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Abstract 4867: The CD40 agonistic antibody APX005M ‘licenses’ antigen presenting cells to promote tumor-specific T-cell responses

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.4867-4867

2016

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Prevention of Acute Graft-Versus-Host Disease by CD4+CD25+ Regulatory T Cells Is Dependent on the CD30/CD153 Pathway

Blood, 2005-11, Vol.106 (11), p.1299-1299

2005

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Dendritic Cells Exposed to Herpes Simplex Virus In Vivo Do Not Produce IFN-{alpha} after Rechallenge with Virus In Vitro and Exhibit Decreased T Cell Alloreactivity

The Journal of immunology (1950), 2004-05, Vol.172 (9), p.5396

Bjorck, Pia

2004

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Plasmacytoid dendritic cell dichotomy: identification of interferon-α producing cells as a phenotypically and functionally distinct subset

The Journal of immunology (1950), 2010-12, Vol.186 (3), p.1477-1485

2010

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Dormant or defiant? Dendritic cells in CVID

Blood, 2004-10, Vol.104 (8), p.2213-2213

Bjoörck, Pia

2004

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The multifaceted murine plasmacytoid dendritic cell

Human immunology, 2002-12, Vol.63 (12), p.1094-1102

Bjoerck, P

2002

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CD40 ligation on human cord blood CD34+ hematopoietic progenitors induces their proliferation and differentiation into functional dendritic cells

The Journal of experimental medicine, 1997-01, Vol.185 (2), p.341-350

1997

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Plasmacytoid Dendritic Cells Take Up Opsonized Antigen Leading to CD4+ and CD8+ T Cell Activation In Vivo1

The Journal of immunology (1950), 2008-09, Vol.181 (6), p.3811-3817

2008

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Stimulation of CD40 in human bladder carcinoma cells inhibits anti‐FAS/APO‐1 (CD95)‐induced apoptosis

International journal of cancer, 1998-09, Vol.77 (6), p.849-853

1998

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APX005M, a CD40 agonist antibody with unique epitope specificity and Fc receptor binding profile for optimal therapeutic application

Isolation and characterization of plasmacytoid dendritic cells from Flt3 ligand and granulocyte-macrophage colony-stimulating factor–treated mice

Influenza A virus elevates active cathepsin B in primary murine DC

CD40 ligation counteracts Fas-induced apoptosis of human dendritic cells

Abstract 5546: A murine reactive version of TAK-573 (anti-CD38 attenuated IFNα fusion protein) shows immunomodulatory and antitumor activity, alone and in combination with standard-of-care agents, in IFNa-insensitive, immunocompetent murine multiple myeloma tumor models

Plasmacytoid Dendritic Cells Take Up Opsonized Antigen Leading to CD4+ and CD8+ T Cell Activation In Vivo

Dendritic cells exposed to herpes simplex virus in vivo do not produce IFN-alpha after rechallenge with virus in vitro and exhibit decreased T cell alloreactivity

A murine reactive version of TAK-573 (anti-CD38-targeted attenuated IFNα fusion protein) shows immunomodulatory and

Cutting Edge: CD19+ Pro-B Cells Can Give Rise to Dendritic Cells In Vitro

TAK-573, an anti-CD38-targeted attenuated interferon alpha (IFNα) fusion protein, showed anti-myeloma tumor responses in combination with standard of care (SOC) agents in multiple myeloma (MM) xenograft tumor models in vivo

The CD40 agonistic monoclonal antibody APX005M has potent immune stimulatory capabilities

ITOC2 – 011. Identification of second-generation potent and selective inhibitors of indoleamine-2,3-dioxygenase-1 (IDO1) for the treatment of cancer

Human Interdigitating Dendritic Cells Induce Isotype Switching and IL-13-Dependent IgM Production in CD40-Activated Naive B Cells

Plasmacytoid dendritic cell dichotomy: identification of IFN-α producing cells as a phenotypically and functionally distinct subset

Abstract 5004: APX005M, a humanized anti-CD40 antibody with strong immune-modulatory activities capable of tumor eradication in vivo

Human interdigitating dendritic cells directly stimulate CD40‐activated naive B cells

Abstract 4867: The CD40 agonistic antibody APX005M ‘licenses’ antigen presenting cells to promote tumor-specific T-cell responses

Prevention of Acute Graft-Versus-Host Disease by CD4+CD25+ Regulatory T Cells Is Dependent on the CD30/CD153 Pathway

Dendritic Cells Exposed to Herpes Simplex Virus In Vivo Do Not Produce IFN-{alpha} after Rechallenge with Virus In Vitro and Exhibit Decreased T Cell Alloreactivity

Plasmacytoid dendritic cell dichotomy: identification of interferon-α producing cells as a phenotypically and functionally distinct subset

Dormant or defiant? Dendritic cells in CVID

The multifaceted murine plasmacytoid dendritic cell

CD40 ligation on human cord blood CD34+ hematopoietic progenitors induces their proliferation and differentiation into functional dendritic cells

Plasmacytoid Dendritic Cells Take Up Opsonized Antigen Leading to CD4+ and CD8+ T Cell Activation In Vivo1

Stimulation of CD40 in human bladder carcinoma cells inhibits anti‐FAS/APO‐1 (CD95)‐induced apoptosis

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