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The Discovery and Development of Liraglutide and Semaglutide

Frontiers in endocrinology (Lausanne), 2019-04, Vol.10, p.155-155

2019

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The GLP-1 Analogs Liraglutide and Semaglutide Reduce Atherosclerosis in ApoE−/− and LDLr−/− Mice by a Mechanism That Includes Inflammatory Pathways

JACC. Basic to translational science, 2018-12, Vol.3 (6), p.844-857

2018

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Glucagon-Like Peptide-1 Receptor Agonists Activate Rodent Thyroid C-Cells Causing Calcitonin Release and C-Cell Proliferation

Endocrinology (Philadelphia), 2010-04, Vol.151 (4), p.1473-1486

2010

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Long-term characterization of the diet-induced obese and diet-resistant rat model: a polygenetic rat model mimicking the human obesity syndrome

Journal of endocrinology, 2010-09, Vol.206 (3), p.287-296

2010

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The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss

The Journal of clinical investigation, 2014-10, Vol.124 (10), p.4473-4488

2014

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Transcellular stomach absorption of a derivatized glucagon-like peptide-1 receptor agonist

Science translational medicine, 2018-11, Vol.10 (467)

2018

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Characterization of the Glucagonlike Peptide-1 Receptor in Male Mouse Brain Using a Novel Antibody and In Situ Hybridization

Endocrinology (Philadelphia), 2018-02, Vol.159 (2), p.665-675

2018

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The GLP-1 receptor agonist liraglutide reduces pathology-specific tau phosphorylation and improves motor function in a transgenic hTauP301L mouse model of tauopathy

Brain research, 2016-03, Vol.1634, p.158-170

2016

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The GLP-1 Receptor Agonist Liraglutide Improves Memory Function and Increases Hippocampal CA1 Neuronal Numbers in a Senescence-Accelerated Mouse Model of Alzheimer's Disease

Journal of Alzheimer's disease, 2015-06, Vol.46 (4), p.877-888

2015

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The Human GLP-1 Analog Liraglutide and the Pancreas: Evidence for the Absence of Structural Pancreatic Changes in Three Species

Diabetes (New York, N.Y.), 2012-05, Vol.61 (5), p.1243-1249

2012

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Crystal Structure of Glucagon-like Peptide-1 in Complex with the Extracellular Domain of the Glucagon-like Peptide-1 Receptor

The Journal of biological chemistry, 2010-01, Vol.285 (1), p.723-730

2010

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Integrated Brain Atlas for Unbiased Mapping of Nervous System Effects Following Liraglutide Treatment

Scientific reports, 2018-07, Vol.8 (1), p.10310-12, Article 10310

2018

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Treatment with glucagon‐like peptide‐1 receptor agonists and incidence of dementia: Data from pooled double‐blind randomized controlled trials and nationwide disease and prescription registers

Alzheimer's & dementia : translational research & clinical interventions, 2022, Vol.8 (1), p.e12268-n/a

2022

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Long-Term Treatment with Liraglutide, a Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist, Has No Effect on β-Amyloid Plaque Load in Two Transgenic APP/PS1 Mouse Models of Alzheimer's Disease

PloS one, 2016-07, Vol.11 (7), p.e0158205-e0158205

2016

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Distribution and ultrastructural localization of the glucagon-like peptide-1 receptor (GLP-1R) in the rat brain

Brain Structure and Function, 2021-01, Vol.226 (1), p.225-245

2021

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Expression of the GLP-1 Receptor in Mouse, Rat, and Human Pancreas

The journal of histochemistry and cytochemistry, 2008-09, Vol.56 (9), p.841-851

2008

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Suppression of food intake by Glp1r/Lepr-coexpressing neurons prevents obesity in mouse models

The Journal of clinical investigation, 2023-10, Vol.133 (19), p.1-11

2023

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A survey of the mouse hindbrain in the fed and fasted states using single-nucleus RNA sequencing

Molecular metabolism (Germany), 2021-11, Vol.53, p.101240, Article 101240

2021

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Liraglutide, a Long-Acting Glucagon-Like Peptide-1 Analog, Reduces Body Weight and Food Intake in Obese Candy-Fed Rats, Whereas a Dipeptidyl Peptidase-IV Inhibitor, Vildagliptin, Does Not

Diabetes (New York, N.Y.), 2007-01, Vol.56 (1), p.8-15

2007

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GLP-1 Receptor Agonists and the Thyroid: C-Cell Effects in Mice Are Mediated via the GLP-1 Receptor and not Associated with RET Activation

Endocrinology (Philadelphia), 2012-03, Vol.153 (3), p.1538-1547

2012

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The Human GLP-1 Analogs Liraglutide and Semaglutide: Absence of Histopathological Effects on the Pancreas in Nonhuman Primates

Diabetes (New York, N.Y.), 2014-07, Vol.63 (7), p.2486-2497

2014

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Quantitative whole-brain 3D imaging of tyrosine hydroxylase-labeled neuron architecture in the mouse MPTP model of Parkinson's disease

Disease models & mechanisms, 2019-11, Vol.12 (11)

2019

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The Glucagon-Like Peptide-1 Receptor—or Not?

Endocrinology (Philadelphia), 2013-01, Vol.154 (1), p.4-8

2013

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Small-molecule agonists for the glucagon-like peptide 1 receptor

Proceedings of the National Academy of Sciences - PNAS, 2007-01, Vol.104 (3), p.937-942

2007

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The Discovery and Development of Liraglutide and Semaglutide

The GLP-1 Analogs Liraglutide and Semaglutide Reduce Atherosclerosis in ApoE−/− and LDLr−/− Mice by a Mechanism That Includes Inflammatory Pathways

Glucagon-Like Peptide-1 Receptor Agonists Activate Rodent Thyroid C-Cells Causing Calcitonin Release and C-Cell Proliferation

Long-term characterization of the diet-induced obese and diet-resistant rat model: a polygenetic rat model mimicking the human obesity syndrome

The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss

Transcellular stomach absorption of a derivatized glucagon-like peptide-1 receptor agonist

Characterization of the Glucagonlike Peptide-1 Receptor in Male Mouse Brain Using a Novel Antibody and In Situ Hybridization

Semaglutide lowers body weight in rodents via distributed neural pathways

The GLP-1 receptor agonist liraglutide reduces pathology-specific tau phosphorylation and improves motor function in a transgenic hTauP301L mouse model of tauopathy

The GLP-1 Receptor Agonist Liraglutide Improves Memory Function and Increases Hippocampal CA1 Neuronal Numbers in a Senescence-Accelerated Mouse Model of Alzheimer's Disease

The Human GLP-1 Analog Liraglutide and the Pancreas: Evidence for the Absence of Structural Pancreatic Changes in Three Species

Crystal Structure of Glucagon-like Peptide-1 in Complex with the Extracellular Domain of the Glucagon-like Peptide-1 Receptor

Integrated Brain Atlas for Unbiased Mapping of Nervous System Effects Following Liraglutide Treatment

Treatment with glucagon‐like peptide‐1 receptor agonists and incidence of dementia: Data from pooled double‐blind randomized controlled trials and nationwide disease and prescription registers

Long-Term Treatment with Liraglutide, a Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist, Has No Effect on β-Amyloid Plaque Load in Two Transgenic APP/PS1 Mouse Models of Alzheimer's Disease

Distribution and ultrastructural localization of the glucagon-like peptide-1 receptor (GLP-1R) in the rat brain

Expression of the GLP-1 Receptor in Mouse, Rat, and Human Pancreas

Suppression of food intake by Glp1r/Lepr-coexpressing neurons prevents obesity in mouse models

A survey of the mouse hindbrain in the fed and fasted states using single-nucleus RNA sequencing

Liraglutide, a Long-Acting Glucagon-Like Peptide-1 Analog, Reduces Body Weight and Food Intake in Obese Candy-Fed Rats, Whereas a Dipeptidyl Peptidase-IV Inhibitor, Vildagliptin, Does Not

GLP-1 Receptor Agonists and the Thyroid: C-Cell Effects in Mice Are Mediated via the GLP-1 Receptor and not Associated with RET Activation

The Human GLP-1 Analogs Liraglutide and Semaglutide: Absence of Histopathological Effects on the Pancreas in Nonhuman Primates

Quantitative whole-brain 3D imaging of tyrosine hydroxylase-labeled neuron architecture in the mouse MPTP model of Parkinson's disease

The Glucagon-Like Peptide-1 Receptor—or Not?

Small-molecule agonists for the glucagon-like peptide 1 receptor

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