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CNS-Derived Blood Exosomes as a Promising Source of Biomarkers: Opportunities and Challenges

Frontiers in molecular neuroscience, 2020-03, Vol.13, p.38-38

2020

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Molecular tweezers for lysine and arginine - powerful inhibitors of pathologic protein aggregation

Chemical communications (Cambridge, England), 2016-01, Vol.52 (76), p.11318-11334

2016

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Structural Study of Metastable Amyloidogenic Protein Oligomers by Photo‐Induced Cross‐Linking of Unmodified Proteins

Amyloid, Prions, and Other Protein Aggregates, Part C, 2006, Vol.413, p.217-236

Bitan, Gal

2006

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Recent advances and future therapy development for Alzheimer's disease and related disorders

Neural regeneration research, 2024-09, Vol.19 (9), p.1877-1878

2024

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Disrupting self-assembly and toxicity of amyloidogenic protein oligomers by "molecular tweezers" - from the test tube to animal models

Current pharmaceutical design, 2014, Vol.20 (15), p.2469

2014

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Amyloid β-Protein (Aβ) Assembly: Aβ40 and Aβ42 Oligomerize through Distinct Pathways

Proceedings of the National Academy of Sciences - PNAS, 2003-01, Vol.100 (1), p.330-335

2003

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α-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes Parkinson’s disease from multiple system atrophy

Acta neuropathologica, 2021-09, Vol.142 (3), p.495-511

2021

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Modulating Self-Assembly of Amyloidogenic Proteins as a Therapeutic Approach for Neurodegenerative Diseases: Strategies and Mechanisms

ChemMedChem, 2012-03, Vol.7 (3), p.359-374

2012

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A minute fraction of α-synuclein in extracellular vesicles may be a major contributor to α-synuclein spreading following autophagy inhibition

Frontiers in molecular neuroscience, 2022-09, Vol.15, p.1001382-1001382

2022

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CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson's disease

Nature communications, 2020-09, Vol.11 (1), p.4885-4885, Article 4885

2020

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Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins

Journal of the American Chemical Society, 2011-10, Vol.133 (42), p.16958-16969

2011

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A shortened Barnes maze protocol reveals memory deficits at 4-months of age in the triple-transgenic mouse model of Alzheimer's disease

PloS one, 2013-11, Vol.8 (11), p.e80355-e80355

2013

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Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation

Alzheimer's research & therapy, 2019-10, Vol.11 (1), p.86-13, Article 86

2019

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Inhibition of Staphylococcus aureus biofilm-forming functional amyloid by molecular tweezers

Cell chemical biology, 2021-09, Vol.28 (9), p.1310-1320.e5

2021

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The molecular tweezer CLR01 inhibits aberrant superoxide dismutase 1 (SOD1) self-assembly in vitro and in the G93A-SOD1 mouse model of ALS

The Journal of biological chemistry, 2019-03, Vol.294 (10), p.3501-3513

2019

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Editorial: Trends in biomarkers for neurodegenerative diseases: Current research and future perspectives

Frontiers in aging neuroscience, 2023-02, Vol.15, p.1153932-1153932

2023

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Editorial: Exosomes: Message in a vesicle

Frontiers in pharmacology, 2022-09, Vol.13, p.1018928-1018928

2022

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Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: The emerging role of oligomeric assemblies

Journal of neuroscience research, 2002-09, Vol.69 (5), p.567-577

2002

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Computational On-Chip Imaging of Nanoparticles and Biomolecules using Ultraviolet Light

Scientific reports, 2017-03, Vol.7 (1), p.44157-44157, Article 44157

2017

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Comparison of Three Amyloid Assembly Inhibitors: The Sugar scyllo-Inositol, the Polyphenol Epigallocatechin Gallate, and the Molecular Tweezer CLR01

ACS chemical neuroscience, 2012-06, Vol.3 (6), p.451-458

2012

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Disease-modifying therapy for proteinopathies: Can the exception become the rule?

Progress in molecular biology and translational science, 2019, Vol.168, p.277-287

Bitan, Gal

2019

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C-terminal peptides coassemble into Aβ42 oligomers and protect neurons against Aβ42-induced neurotoxicity

Proceedings of the National Academy of Sciences - PNAS, 2008-09, Vol.105 (37), p.14175-14180

2008

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Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes

Communications biology, 2021-09, Vol.4 (1), p.1076-1076, Article 1076

2021

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Molecular Lysine Tweezers Counteract Aberrant Protein Aggregation

Frontiers in chemistry, 2019-10, Vol.7, p.657

2019

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Correction to: α-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes Parkinson’s disease from multiple system atrophy

Acta neuropathologica, 2021-09, Vol.142 (3), p.513-513

2021

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CNS-Derived Blood Exosomes as a Promising Source of Biomarkers: Opportunities and Challenges

Molecular tweezers for lysine and arginine - powerful inhibitors of pathologic protein aggregation

Structural Study of Metastable Amyloidogenic Protein Oligomers by Photo‐Induced Cross‐Linking of Unmodified Proteins

Recent advances and future therapy development for Alzheimer's disease and related disorders

Disrupting self-assembly and toxicity of amyloidogenic protein oligomers by "molecular tweezers" - from the test tube to animal models

Amyloid β-Protein (Aβ) Assembly: Aβ40 and Aβ42 Oligomerize through Distinct Pathways

α-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes Parkinson’s disease from multiple system atrophy

Modulating Self-Assembly of Amyloidogenic Proteins as a Therapeutic Approach for Neurodegenerative Diseases: Strategies and Mechanisms

A minute fraction of α-synuclein in extracellular vesicles may be a major contributor to α-synuclein spreading following autophagy inhibition

CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson's disease

Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins

A shortened Barnes maze protocol reveals memory deficits at 4-months of age in the triple-transgenic mouse model of Alzheimer's disease

Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation

Inhibition of Staphylococcus aureus biofilm-forming functional amyloid by molecular tweezers

The molecular tweezer CLR01 inhibits aberrant superoxide dismutase 1 (SOD1) self-assembly in vitro and in the G93A-SOD1 mouse model of ALS

Editorial: Trends in biomarkers for neurodegenerative diseases: Current research and future perspectives

Editorial: Exosomes: Message in a vesicle

Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: The emerging role of oligomeric assemblies

Computational On-Chip Imaging of Nanoparticles and Biomolecules using Ultraviolet Light

Comparison of Three Amyloid Assembly Inhibitors: The Sugar scyllo-Inositol, the Polyphenol Epigallocatechin Gallate, and the Molecular Tweezer CLR01

Disease-modifying therapy for proteinopathies: Can the exception become the rule?

C-terminal peptides coassemble into Aβ42 oligomers and protect neurons against Aβ42-induced neurotoxicity

Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes

Molecular Lysine Tweezers Counteract Aberrant Protein Aggregation

Correction to: α-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes Parkinson’s disease from multiple system atrophy

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