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Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway

The Journal of pharmacology and experimental therapeutics, 2012-04, Vol.341 (1), p.274-284

2012

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Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

Brain (London, England : 1878), 2011-03, Vol.134 (3), p.678-692

2011

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STAR-0215 is a Novel, Long-Acting Monoclonal Antibody Inhibitor of Plasma Kallikrein for the Potential Treatment of Hereditary Angioedema

The Journal of pharmacology and experimental therapeutics, 2023-11, Vol.387 (2), p.214-225

2023

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Pharmacodynamics of Dimethyl Fumarate Are Tissue Specific and Involve NRF2-Dependent and -Independent Mechanisms

Antioxidants & redox signaling, 2016-06, Vol.24 (18), p.1058-1071

2016

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Structure of STAR-0215 Bound to Active Plasma Kallikrein Reveals a Novel Mechanism of Enzyme Inhibition

Journal of allergy and clinical immunology, 2023-02, Vol.151 (2), p.AB142-AB142

2023

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Dipeptidyl Peptidase 2 is an essential survival factor in the regulation of cell quiescence

Cell cycle (Georgetown, Tex.), 2009-08, Vol.8 (15), p.2425-2434

2009

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QLS-215 is a Long-Acting Monoclonal Antibody Plasma Kallikrein Inhibitor in Development for Treatment of HAE

Journal of allergy and clinical immunology, 2022-02, Vol.149 (2), p.AB167-AB167

2022

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Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

Brain (London, England : 1878), 2011-03, Vol.134 (Pt 3), p.678-692

2011

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Initial Results from a Phase 1 Single Ascending Dose Clinical Trial of STAR-0215, an Investigational Long-Acting Monoclonal Antibody Plasma Kallikrein Inhibitor for Hereditary Angioedema (HAE), in Healthy Subjects Followed for at Least 3 Months

Journal of allergy and clinical immunology, 2023-02, Vol.151 (2), p.AB136-AB136

2023

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TRAF3 Controls Activation of the Canonical and Alternative NFκB by the Lymphotoxin Beta Receptor

The Journal of biological chemistry, 2010-04, Vol.285 (17), p.12971-12978

2010

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Disease-modifying effects of edasalonexent, an NF-κB inhibitor, in young boys with Duchenne muscular dystrophy: Results of the MoveDMD phase 2 and open label extension trial

Neuromuscular disorders : NMD, 2021-05, Vol.31 (5), p.385-396

2021

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Preservation of Mitochondrial Bioenergetics with CAT-4001 after Peroxide Injury

Biochimica et biophysica acta. Bioenergetics, 2018-09, Vol.1859, p.e48-e49

2018

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Move DMD Results: Effects of Edasalonexent, an NF-kB Inhibitor, in 4 to 7 Year Old Patients with Duchenne Muscular Dystrophy (P3.210)

Neurology, 2017-04, Vol.88 (16_supplement)

2017

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Synthesis and Characterization of Fatty Acid Conjugates of Niacin and Salicylic Acid

Journal of medicinal chemistry, 2016-02, Vol.59 (3), p.1217-1231

2016

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Abstract 237: CAT-2003 is a Novel Small Molecule That Activates Lipoprotein Lipase and Reduces Fasting and Postprandial Triglycerides

Arteriosclerosis, thrombosis, and vascular biology, 2014-05, Vol.34 (suppl_1)

2014

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Abstract 6: CAT-2003 is a Novel Small Molecule That Inhibits Proprotein Convertase Subtilisin/Kexin Type 9 Production and Lowers Non--High-Density Lipoprotein Cholesterol

Arteriosclerosis, thrombosis, and vascular biology, 2014-05, Vol.34 (suppl_1)

2014

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Phase 1 Study of Edasalonexent (CAT-1004), an Oral NF-κB Inhibitor, in Pediatric Patients with Duchenne Muscular Dystrophy

Journal of neuromuscular diseases, 2019-01, Vol.6 (1), p.43-54

2019

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72 A Novel Salicylate Based NF-κB Inhibitor CAT-1004 Provides Superior Efficacy and Potency Compared to 5-ASA and Is Efficacious in Multiple Rodent Models of Inflammatory Bowel Disease

Gastroenterology (New York, N.Y. 1943), 2014-05, Vol.146 (5), p.S-20-S-20

2014

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BG-12 (Dimethyl Fumarate) Pharmacodynamic Responses Have Distinct Temporal Profiles and Are Dose-Dependent (P05.146)

Neurology, 2013-02, Vol.80 (7_supplement)

2013

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CAT‐2003: A novel sterol regulatory element‐binding protein inhibitor that reduces steatohepatitis, plasma lipids, and atherosclerosis in apolipoprotein E3‐Leiden mice

Hepatology communications, 2017-06, Vol.1 (4), p.311-325

2017

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Lymphocyte quiescence factor Dpp2 is transcriptionally activated by KLF2 and TOB1

Molecular immunology, 2008-08, Vol.45 (13), p.3618-3623

2008

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Lymphocyte quiescence factor Dpp2 is transcriptionally activated by KLF2 and TOB11

Molecular immunology, 2008-06, Vol.45 (13), p.3618-3623

2008

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TRAF3 controls activation of the canonical and alternative NFkappaB by the lymphotoxin beta receptor

The Journal of biological chemistry, 2010-04, Vol.285 (17), p.12971-12978

2010

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Public Health Approach to Developing Palliative Care

JNMA; journal of the Nepal Medical Association, 2022-08, Vol.60 (252), p.750-752

2022

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Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

STAR-0215 is a Novel, Long-Acting Monoclonal Antibody Inhibitor of Plasma Kallikrein for the Potential Treatment of Hereditary Angioedema

Pharmacodynamics of Dimethyl Fumarate Are Tissue Specific and Involve NRF2-Dependent and -Independent Mechanisms

Structure of STAR-0215 Bound to Active Plasma Kallikrein Reveals a Novel Mechanism of Enzyme Inhibition

Dipeptidyl Peptidase 2 is an essential survival factor in the regulation of cell quiescence

QLS-215 is a Long-Acting Monoclonal Antibody Plasma Kallikrein Inhibitor in Development for Treatment of HAE

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

Initial Results from a Phase 1 Single Ascending Dose Clinical Trial of STAR-0215, an Investigational Long-Acting Monoclonal Antibody Plasma Kallikrein Inhibitor for Hereditary Angioedema (HAE), in Healthy Subjects Followed for at Least 3 Months

TRAF3 Controls Activation of the Canonical and Alternative NFκB by the Lymphotoxin Beta Receptor

Disease-modifying effects of edasalonexent, an NF-κB inhibitor, in young boys with Duchenne muscular dystrophy: Results of the MoveDMD phase 2 and open label extension trial

Preservation of Mitochondrial Bioenergetics with CAT-4001 after Peroxide Injury

Edasalonexent, an NF-kB Inhibitor, Slows Longer-Term Disease Progression on Multiple Functional and MRI Assessments Compared to Control Period in 4 to 7-Year Old Patients with Duchenne Muscular Dystrophy (S51.006)

Move DMD Results: Effects of Edasalonexent, an NF-kB Inhibitor, in 4 to 7 Year Old Patients with Duchenne Muscular Dystrophy (P3.210)

Synthesis and Characterization of Fatty Acid Conjugates of Niacin and Salicylic Acid

Abstract 237: CAT-2003 is a Novel Small Molecule That Activates Lipoprotein Lipase and Reduces Fasting and Postprandial Triglycerides

Abstract 6: CAT-2003 is a Novel Small Molecule That Inhibits Proprotein Convertase Subtilisin/Kexin Type 9 Production and Lowers Non--High-Density Lipoprotein Cholesterol

Phase 1 Study of Edasalonexent (CAT-1004), an Oral NF-κB Inhibitor, in Pediatric Patients with Duchenne Muscular Dystrophy

72 A Novel Salicylate Based NF-κB Inhibitor CAT-1004 Provides Superior Efficacy and Potency Compared to 5-ASA and Is Efficacious in Multiple Rodent Models of Inflammatory Bowel Disease

BG-12 (Dimethyl Fumarate) Pharmacodynamic Responses Have Distinct Temporal Profiles and Are Dose-Dependent (P05.146)

CAT‐2003: A novel sterol regulatory element‐binding protein inhibitor that reduces steatohepatitis, plasma lipids, and atherosclerosis in apolipoprotein E3‐Leiden mice

Lymphocyte quiescence factor Dpp2 is transcriptionally activated by KLF2 and TOB1

Lymphocyte quiescence factor Dpp2 is transcriptionally activated by KLF2 and TOB11

TRAF3 controls activation of the canonical and alternative NFkappaB by the lymphotoxin beta receptor

Public Health Approach to Developing Palliative Care

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