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The epigenetic immunomodulator, HBI-8000, enhances the response and reverses resistance to checkpoint inhibitors

BMC cancer, 2021-08, Vol.21 (1), p.1-969, Article 969

2021

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Induction of apoptosis by HBI‐8000 in adult T‐cell leukemia/lymphoma is associated with activation of Bim and NLRP3

Cancer science, 2016-08, Vol.107 (8), p.1124-1133

2016

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The rexinoid bexarotene represses cyclin D1 transcription by inducing the DEC2 transcriptional repressor

Breast cancer research and treatment, 2011-08, Vol.128 (3), p.667-677

2011

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The combination of tamoxifen and the rexinoid LG100268 prevents ER-positive and ER-negative mammary tumors in p53-null mammary gland mice

Cancer prevention research (Philadelphia, Pa.), 2012-10, Vol.5 (10), p.1195-1202

2012

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The Rexinoid LG100268 Prevents the Development of Preinvasive and Invasive Estrogen Receptor–Negative Tumors in MMTV-erbB2 Mice

Clinical cancer research, 2007-10, Vol.13 (20), p.6224-6231

2007

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Apoptotic cell death induced by c- myc is inhibited by bcl -2

Nature (London), 1992-10, Vol.359 (6395), p.552-554

1992

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Cancer-preventive rexinoid modulates neutral lipid contents of mammary epithelial cells through a peroxisome proliferator-activated receptor γ-dependent mechanism

Molecular pharmacology, 2012-02, Vol.81 (2), p.228-238

2012

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A Selective Retinoid X Receptor Agonist Bexarotene (Targretin) Prevents and Overcomes Acquired Paclitaxel (Taxol) Resistance in Human Non–Small Cell Lung Cancer

Clinical cancer research, 2004-12, Vol.10 (24), p.8656-8664

2004

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G0S2 is an all-trans-retinoic acid target gene

International journal of oncology, 2008-08, Vol.33 (2), p.397-404

2008

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Rexinoid-induced Expression of IGFBP-6 Requires RARβ-dependent Permissive Cooperation of Retinoid Receptors and AP-1

The Journal of biological chemistry, 2009-01, Vol.284 (1), p.345-353

2009

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Synthesis and Characterization of Nonsteroidal Glucocorticoid Receptor Modulators for Multiple Myeloma

Journal of medicinal chemistry, 2007-09, Vol.50 (19), p.4699-4709

2007

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In vivo and Microarray Analysis of Rexinoid-Responsive Anaplastic Thyroid Carcinoma

Clinical cancer research, 2008-01, Vol.14 (2), p.589-596

2008

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FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway

Immunity (Cambridge, Mass.), 1995-04, Vol.2 (4), p.341-351

1995

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Role for c-myc in Activation-Induced Apoptotic Cell Death in T Cell Hybridomas

Science (American Association for the Advancement of Science), 1992-07, Vol.257 (5067), p.212-214

1992

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Receptor-selective retinoids inhibit the growth of normal and malignant breast cells by inducing G1 cell cycle blockade

Breast cancer research and treatment, 2006-03, Vol.96 (2), p.147-157

2006

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Combination chemoprevention of HER2/neu-induced breast cancer using a cyclooxygenase-2 inhibitor and a retinoid X receptor-selective retinoid

Cancer prevention research (Philadelphia, Pa.), 2008-08, Vol.1 (3), p.208-214

2008

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Transcriptomic signature of bexarotene (rexinoid LGD1069) on mammary gland from three transgenic mouse mammary cancer models

BMC medical genomics, 2008-09, Vol.1 (1), p.40-40, Article 40

2008

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Retinoid-X receptor signalling in the developing spinal cord

Nature (London), 1998-09, Vol.395 (6700), p.398-402

1998

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The retinoid X receptor agonist bexarotene (Targretin) synergistically enhances the growth inhibitory activity of cytotoxic drugs in non-small cell lung cancer cells

Lung cancer (Amsterdam, Netherlands), 2005-10, Vol.50 (1), p.9-18

2005

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Combination PPARγ and RXR Agonist Treatment in Melanoma Cells: Functional Importance of S100A2

PPAR Research, 2010-01, Vol.2010 (2010), p.562-569

2010

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The activity of the HDAC inhibitor HBI-8000 (Chidamide) combined with eribulin on 4T1 spontaneous metastasis development

Journal of clinical oncology, 2017-05, Vol.35 (15_suppl), p.e14055-e14055

2017

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Bruton's Tyrosine Kinase Regulates Apoptosis and JNK/SAPK Kinase Activity

Proceedings of the National Academy of Sciences - PNAS, 1997-04, Vol.94 (8), p.3938-3942

1997

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Identification of modulated genes by three classes of chemopreventive agents at preneoplastic stages in a p53-null mouse mammary tumor model

Cancer prevention research (Philadelphia, Pa.), 2009-02, Vol.2 (2), p.175-184

2009

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RXR-induced TNF-α suppression is reversed by morphine in activated U937 cells

Journal of neuroimmunology, 2004-02, Vol.147 (1), p.99-105

2004

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Nuclear receptor activation and interaction with morphine

Journal of neuroimmunology, 2004-12, Vol.157 (1), p.61-65

2004

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The epigenetic immunomodulator, HBI-8000, enhances the response and reverses resistance to checkpoint inhibitors

Induction of apoptosis by HBI‐8000 in adult T‐cell leukemia/lymphoma is associated with activation of Bim and NLRP3

The rexinoid bexarotene represses cyclin D1 transcription by inducing the DEC2 transcriptional repressor

The combination of tamoxifen and the rexinoid LG100268 prevents ER-positive and ER-negative mammary tumors in p53-null mammary gland mice

The Rexinoid LG100268 Prevents the Development of Preinvasive and Invasive Estrogen Receptor–Negative Tumors in MMTV-erbB2 Mice

Apoptotic cell death induced by c- myc is inhibited by bcl -2

Cancer-preventive rexinoid modulates neutral lipid contents of mammary epithelial cells through a peroxisome proliferator-activated receptor γ-dependent mechanism

A Selective Retinoid X Receptor Agonist Bexarotene (Targretin) Prevents and Overcomes Acquired Paclitaxel (Taxol) Resistance in Human Non–Small Cell Lung Cancer

G0S2 is an all-trans-retinoic acid target gene

Rexinoid-induced Expression of IGFBP-6 Requires RARβ-dependent Permissive Cooperation of Retinoid Receptors and AP-1

Synthesis and Characterization of Nonsteroidal Glucocorticoid Receptor Modulators for Multiple Myeloma

In vivo and Microarray Analysis of Rexinoid-Responsive Anaplastic Thyroid Carcinoma

FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway

Role for c-myc in Activation-Induced Apoptotic Cell Death in T Cell Hybridomas

Receptor-selective retinoids inhibit the growth of normal and malignant breast cells by inducing G1 cell cycle blockade

Combination chemoprevention of HER2/neu-induced breast cancer using a cyclooxygenase-2 inhibitor and a retinoid X receptor-selective retinoid

Transcriptomic signature of bexarotene (rexinoid LGD1069) on mammary gland from three transgenic mouse mammary cancer models

Retinoid-X receptor signalling in the developing spinal cord

The retinoid X receptor agonist bexarotene (Targretin) synergistically enhances the growth inhibitory activity of cytotoxic drugs in non-small cell lung cancer cells

Combination PPARγ and RXR Agonist Treatment in Melanoma Cells: Functional Importance of S100A2

The activity of the HDAC inhibitor HBI-8000 (Chidamide) combined with eribulin on 4T1 spontaneous metastasis development

Bruton's Tyrosine Kinase Regulates Apoptosis and JNK/SAPK Kinase Activity

Identification of modulated genes by three classes of chemopreventive agents at preneoplastic stages in a p53-null mouse mammary tumor model

RXR-induced TNF-α suppression is reversed by morphine in activated U937 cells

Nuclear receptor activation and interaction with morphine

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