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Novel prodrugs which are activated to cytotoxic alkylating agents by carboxypeptidase G2

Journal of medicinal chemistry, 1990-02, Vol.33 (2), p.677-681

1990

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Folate-Based Inhibitors of Thymidylate Synthase: Synthesis and Antitumor Activity of γ-Linked Sterically Hindered Dipeptide Analogues of 2-Desamino-2-methyl-N10-propargyl-5,8-dideazafolic Acid (ICI 198583)

Journal of medicinal chemistry, 1997-05, Vol.40 (10), p.1495-1510

1997

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Syntheses and thymidylate synthase inhibitory activity of the poly-.gamma.-glutamyl conjugates of N-[5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino]-2-thenoyl]-L-glutamic acid (ICI D1694) and other quinazoline antifolates

Journal of medicinal chemistry, 1992-03, Vol.35 (5), p.859-866

1992

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Pharmacokinetic studies with the antifolate C2-desamino-C2-methyl-N10-propargyl-2'-trifluoromethyl-5,8-dideazafolic acid (CB3988) in mice and rats using in vivo 19F-NMR spectroscopy

British journal of cancer, 1990-11, Vol.62 (5), p.766-772

1990

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Mechanism of photooxidation of bacteriochlorophyll c derivatives. A possible model for natural chlorophyll breakdown

The Journal of biological chemistry, 1980-09, Vol.255 (17), p.8063-8068

1980

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Quinazoline Antifolate Thymidylate Synthase Inhibitors: γ-Linked l-d, d-d, and d-l Dipeptide Analogues of 2-Desamino-2-methyl-N10-propargyl-5,8-dideazafolic Acid (ICI 198583)

Journal of medicinal chemistry, 1996-01, Vol.39 (1), p.73-85

1996

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The in vivo metabolic stability of dipeptide analogues of the quinazoline antifolate, ICI 198583, in mice

Biochemical pharmacology, 1993-12, Vol.46 (12), p.2229-2234

1993

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Quinazoline-antifolate thymidylate synthase inhibitors: benzoyl ring modifications in the C2-methyl series

Journal of medicinal chemistry, 1990-11, Vol.33 (11), p.3072-3078

1990

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Antihypertensive ureidopiperidines

Journal of medicinal chemistry, 1980-08, Vol.23 (8), p.857-861

1980

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The Synthesis and Thymidylate Synthase Inhibitory Activity of L-.gamma.-L-Linked Dipeptide and L-.gamma.-Amide Analogs of 2-Desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583)

Journal of medicinal chemistry, 1994-09, Vol.37 (20), p.3294-3302

1994

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Prodrugs of thymidylate synthase inhibitors: potential for antibody directed enzyme prodrug therapy (ADEPT)

Anti-cancer drug design, 1996-12, Vol.11 (8), p.625

1996

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Quinazoline-based thymidylate synthase inhibitors: relationship between structural modifications and polyglutamation

Anti-cancer drug design, 1995-10, Vol.10 (7), p.573

1995

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Electrospray ionization mass spectrometry for analysis of low-molecular-weight anticancer drugs and their analogues

Journal of the American Society for Mass Spectrometry, 1993-07, Vol.4 (7), p.588-595

1993

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The measurement of polyglutamate metabolites of the thymidylate synthase inhibitoR, ICI D1694, in mouse and human cultured cells

Biochemical pharmacology, 1993-02, Vol.45 (4), p.863-869

1993

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Convenient Preparation of α-Tert-Butyl N-Blocked Glutamates Through γ-Allyl Ester Protection

Synthetic communications, 1995-04, Vol.25 (7), p.947-958

1995

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Electrospray ionization mass spectrometry for analysis of low-molecular-weight anticancer drugs and their analogues: Electrospray ionization

Journal of the American Society for Mass Spectrometry, 1993, Vol.4 (7), p.588-595

1993

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Synthesis of a tetrafluorinated analogue of the quinazoline antifolate 2-desamino-2-methyl- N10-propargyl-5,8-dideazafolic acid

Journal of fluorine chemistry, 1993, Vol.60 (1), p.31-38

1993

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Quinazoline antifolates inhibiting thymidylate synthase: synthesis of gamma-linked peptide and amide analogues of 2-desamino-2-methyl-N10-propargyl- 5,8-dideazafolic acid (ICI 198583)

Advances in experimental medicine and biology, 1993, Vol.338, p.593

1993

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The measurement of polyglutamate metabolites of the thymidylate synthase inhibitor, IC D1694, in mouse and human cultured cells

Biochemical pharmacology, 1993, Vol.45 (4), p.863-869

1993

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Gamma-linked dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8- dideazafolate as antitumour agents

Advances in experimental medicine and biology, 1993, Vol.338, p.579

1993

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ChemInform Abstract: Convenient Preparation of α-tert-Butyl N-Blocked Glutamates Through γ-Allyl Ester Protection

ChemInform, 1995-07, Vol.26 (30), p.no-no

1995

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ChemInform Abstract: Synthesis of a Tetrafluorinated Analogue (VII) of the Quinazoline Antifolate 2-Desamino-2-methyl-N10-propargyl-5,8-dideazafolic Acid

ChemInform, 1993-08, Vol.24 (35), p.no-no

1993

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ChemInform Abstract: MESO (METHINE) FUNCTIONALIZATION OF OCTAALKYLPORPHYRINS

Chemischer Informationsdienst, 1981-12, Vol.12 (51)

1981

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ChemInform Abstract: Synthesis of Novel Quinazoline-Based Antifolates with Modified Glutamate Side Chains as Potential Inhibitors of Thymidylate Synthase and Antitumor Agents

ChemInform, 1998-02, Vol.29 (5), p.no-no

1998

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ChemInform Abstract: Quinazoline Antifolate Thymidylate Synthase Inhibitors: γ-Linked L-D, D-D, and D-L Dipeptide Analogues of 2-Desamino-2-methyl-N10- propargyl-5,8-dideazafolic Acid (ICI 198583)

ChemInform, 1996-04, Vol.27 (18), p.no-no

1996

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Novel prodrugs which are activated to cytotoxic alkylating agents by carboxypeptidase G2

Folate-Based Inhibitors of Thymidylate Synthase: Synthesis and Antitumor Activity of γ-Linked Sterically Hindered Dipeptide Analogues of 2-Desamino-2-methyl-N10-propargyl-5,8-dideazafolic Acid (ICI 198583)

Syntheses and thymidylate synthase inhibitory activity of the poly-.gamma.-glutamyl conjugates of N-[5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino]-2-thenoyl]-L-glutamic acid (ICI D1694) and other quinazoline antifolates

Pharmacokinetic studies with the antifolate C2-desamino-C2-methyl-N10-propargyl-2'-trifluoromethyl-5,8-dideazafolic acid (CB3988) in mice and rats using in vivo 19F-NMR spectroscopy

Mechanism of photooxidation of bacteriochlorophyll c derivatives. A possible model for natural chlorophyll breakdown

Quinazoline Antifolate Thymidylate Synthase Inhibitors: γ-Linked l-d, d-d, and d-l Dipeptide Analogues of 2-Desamino-2-methyl-N10-propargyl-5,8-dideazafolic Acid (ICI 198583)

The in vivo metabolic stability of dipeptide analogues of the quinazoline antifolate, ICI 198583, in mice

Quinazoline-antifolate thymidylate synthase inhibitors: benzoyl ring modifications in the C2-methyl series

Antihypertensive ureidopiperidines

The Synthesis and Thymidylate Synthase Inhibitory Activity of L-.gamma.-L-Linked Dipeptide and L-.gamma.-Amide Analogs of 2-Desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583)

Prodrugs of thymidylate synthase inhibitors: potential for antibody directed enzyme prodrug therapy (ADEPT)

Quinazoline-based thymidylate synthase inhibitors: relationship between structural modifications and polyglutamation

Electrospray ionization mass spectrometry for analysis of low-molecular-weight anticancer drugs and their analogues

The measurement of polyglutamate metabolites of the thymidylate synthase inhibitoR, ICI D1694, in mouse and human cultured cells

Convenient Preparation of α-Tert-Butyl N-Blocked Glutamates Through γ-Allyl Ester Protection

Electrospray ionization mass spectrometry for analysis of low-molecular-weight anticancer drugs and their analogues: Electrospray ionization

Synthesis of a tetrafluorinated analogue of the quinazoline antifolate 2-desamino-2-methyl- N10-propargyl-5,8-dideazafolic acid

Quinazoline antifolates inhibiting thymidylate synthase: synthesis of gamma-linked peptide and amide analogues of 2-desamino-2-methyl-N10-propargyl- 5,8-dideazafolic acid (ICI 198583)

The measurement of polyglutamate metabolites of the thymidylate synthase inhibitor, IC D1694, in mouse and human cultured cells

Gamma-linked dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8- dideazafolate as antitumour agents

ChemInform Abstract: Convenient Preparation of α-tert-Butyl N-Blocked Glutamates Through γ-Allyl Ester Protection

ChemInform Abstract: Synthesis of a Tetrafluorinated Analogue (VII) of the Quinazoline Antifolate 2-Desamino-2-methyl-N10-propargyl-5,8-dideazafolic Acid

ChemInform Abstract: MESO (METHINE) FUNCTIONALIZATION OF OCTAALKYLPORPHYRINS

ChemInform Abstract: Synthesis of Novel Quinazoline-Based Antifolates with Modified Glutamate Side Chains as Potential Inhibitors of Thymidylate Synthase and Antitumor Agents

ChemInform Abstract: Quinazoline Antifolate Thymidylate Synthase Inhibitors: γ-Linked L-D, D-D, and D-L Dipeptide Analogues of 2-Desamino-2-methyl-N10- propargyl-5,8-dideazafolic Acid (ICI 198583)

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