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Antiviral drugs for cytomegalovirus diseases

Antiviral research, 2006-09, Vol.71 (2), p.154-163

Biron, Karen K.

2006

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Potent and Selective Inhibition of Human Cytomegalovirus Replication by 1263W94, a Benzimidazole l-Riboside with a Unique Mode of Action

Antimicrobial Agents and Chemotherapy, 2002-08, Vol.46 (8), p.2365-2372

2002

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In Vitro Activities of Benzimidazole d- and l-Ribonucleosides against Herpesviruses

Antimicrobial Agents and Chemotherapy, 2003-07, Vol.47 (7), p.2186-2192

2003

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The Human Cytomegalovirus UL44 Protein Is a Substrate for the UL97 Protein Kinase

Journal of Virology, 2003-07, Vol.77 (14), p.7720-7727

2003

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Mutations in the Human Cytomegalovirus UL27 Gene That Confer Resistance to Maribavir

Journal of Virology, 2004-07, Vol.78 (13), p.7124-7130

2004

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Preclinical and Toxicology Studies of 1263W94, a Potent and Selective Inhibitor of Human Cytomegalovirus Replication

Antimicrobial Agents and Chemotherapy, 2002-08, Vol.46 (8), p.2373-2380

2002

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Mechanism of Action of the Ribopyranoside Benzimidazole GW275175X against Human Cytomegalovirus

Antimicrobial Agents and Chemotherapy, 2004-05, Vol.48 (5), p.1647-1651

2004

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Activities of Benzimidazole d- and l-Ribonucleosides in Animal Models of Cytomegalovirus Infections

Antimicrobial Agents and Chemotherapy, 2004-05, Vol.48 (5), p.1749-1755

2004

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Interactions of 1263W94 with Other Antiviral Agents in Inhibition of Human Cytomegalovirus Replication

Antimicrobial Agents and Chemotherapy, 2003-04, Vol.47 (4), p.1468-1471

2003

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Acyclovir Is Phosphorylated by the Human Cytomegalovirus UL97 Protein

Antimicrobial Agents and Chemotherapy, 1999-08, Vol.43 (8), p.1941-1946

1999

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Mutations Conferring Ganciclovir Resistance in a Cohort of Patients with Acquired Immunodeficiency Syndrome and Cytomegalovirus Retinitis

The Journal of infectious diseases, 2001-01, Vol.183 (2), p.333-337

2001

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Phosphorylation of β-d-Ribosylbenzimidazoles Is Not Required for Activity against Human Cytomegalovirus

Antimicrobial Agents and Chemotherapy, 2002-02, Vol.46 (2), p.478-486

2002

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The Cys607→Tyr Change in the UL97 Phosphotransferase Confers Ganciclovir Resistance to Two Human Cytomegalovirus Strains Recovered from Two Immunocompromised Patients

Antimicrobial Agents and Chemotherapy, 1998-02, Vol.42 (2), p.444-446

1998

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Inhibition of Human Cytomegalovirus DNA Maturation by a Benzimidazole Ribonucleoside Is Mediated through the UL89 Gene Product

Journal of Virology, 1998-01, Vol.72 (1), p.717-725

1998

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Resistance of Human Cytomegalovirus to Benzimidazole Ribonucleosides Maps to Two Open Reading Frames: UL89 and UL56

Journal of Virology, 1998-06, Vol.72 (6), p.4721-4728

1998

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"The end of innocence" revisited: resistance of herpesviruses to antiviral drugs

Clinical Microbiology Reviews, 1994-01, Vol.7 (1), p.1-13

1994

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Inhibition of Epstein-Barr Virus Replication by a Benzimidazole l-Riboside: Novel Antiviral Mechanism of 5,6-Dichloro-2-(Isopropylamino)-1-β-l-Ribofuranosyl-1H-Benzimidazole

Journal of Virology, 1999-09, Vol.73 (9), p.7271-7277

1999

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Inhibition of Ganciclovir-Susceptible and -Resistant Human Cytomegalovirus Clinical Isolates by the Benzimidazole l-Riboside 1263W94

Clinical and Diagnostic Laboratory Immunology, 2001-11, Vol.8 (6), p.1279

2001

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An Enantiospecific Synthesis of the Human Cytomegalovirus Antiviral Agent [(R)-3-((2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-4- hydroxybutyl]phosphonic Acid

Journal of medicinal chemistry, 1994-04, Vol.37 (9), p.1371-1377

1994

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Progressive disease due to ganciclovir-resistant cytomegalovirus in immunocompromised patients

The New England journal of medicine, 1989-02, Vol.320 (5), p.289

1989

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Interpreting Human Cytomegalovirus Antiviral Drug Susceptibility Testing: The Role of Mixed Virus Populations [with Reply]

The Journal of infectious diseases, 1998-03, Vol.177 (3), p.823-824

1998

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Emergence of acyclovir-resistant varicella zoster virus in an AIDS patient on prolonged acyclovir therapy

AIDS (London), 1990-06, Vol.4 (6), p.577-579

1990

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Analysis of the UL97 phosphotransferase coding sequence in clinical cytomegalovirus isolates and identification of mutations conferring ganciclovir resistance

The Journal of infectious diseases, 1995-03, Vol.171 (3), p.576

1995

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Maribavir: A Novel Benzimidazole Ribonucleoside for the Prevention and Treatment of Cytomegalovirus Diseases

Antiviral Drug Strategies, 2011, Vol.50, p.209-226

2011

Volltextzugriff (PDF)

Single amino acid changes in the DNA polymerase confer foscarnet resistance and slow-growth phenotype, while mutations in the UL97-encoded phosphotransferase confer ganciclovir resistance in three double-resistant human cytomegalovirus strains recovered from patients with AIDS

Journal of Virology, 1996-03, Vol.70 (3), p.1390-1395

1996

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Antiviral drugs for cytomegalovirus diseases

Potent and Selective Inhibition of Human Cytomegalovirus Replication by 1263W94, a Benzimidazole l-Riboside with a Unique Mode of Action

In Vitro Activities of Benzimidazole d- and l-Ribonucleosides against Herpesviruses

The Human Cytomegalovirus UL44 Protein Is a Substrate for the UL97 Protein Kinase

Mutations in the Human Cytomegalovirus UL27 Gene That Confer Resistance to Maribavir

Preclinical and Toxicology Studies of 1263W94, a Potent and Selective Inhibitor of Human Cytomegalovirus Replication

Mechanism of Action of the Ribopyranoside Benzimidazole GW275175X against Human Cytomegalovirus

Activities of Benzimidazole d- and l-Ribonucleosides in Animal Models of Cytomegalovirus Infections

Interactions of 1263W94 with Other Antiviral Agents in Inhibition of Human Cytomegalovirus Replication

Acyclovir Is Phosphorylated by the Human Cytomegalovirus UL97 Protein

Mutations Conferring Ganciclovir Resistance in a Cohort of Patients with Acquired Immunodeficiency Syndrome and Cytomegalovirus Retinitis

Phosphorylation of β-d-Ribosylbenzimidazoles Is Not Required for Activity against Human Cytomegalovirus

The Cys607→Tyr Change in the UL97 Phosphotransferase Confers Ganciclovir Resistance to Two Human Cytomegalovirus Strains Recovered from Two Immunocompromised Patients

Inhibition of Human Cytomegalovirus DNA Maturation by a Benzimidazole Ribonucleoside Is Mediated through the UL89 Gene Product

Resistance of Human Cytomegalovirus to Benzimidazole Ribonucleosides Maps to Two Open Reading Frames: UL89 and UL56

"The end of innocence" revisited: resistance of herpesviruses to antiviral drugs

Inhibition of Epstein-Barr Virus Replication by a Benzimidazole l-Riboside: Novel Antiviral Mechanism of 5,6-Dichloro-2-(Isopropylamino)-1-β-l-Ribofuranosyl-1H-Benzimidazole

Inhibition of Ganciclovir-Susceptible and -Resistant Human Cytomegalovirus Clinical Isolates by the Benzimidazole l-Riboside 1263W94

An Enantiospecific Synthesis of the Human Cytomegalovirus Antiviral Agent [(R)-3-((2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-4- hydroxybutyl]phosphonic Acid

Progressive disease due to ganciclovir-resistant cytomegalovirus in immunocompromised patients

Interpreting Human Cytomegalovirus Antiviral Drug Susceptibility Testing: The Role of Mixed Virus Populations [with Reply]

Emergence of acyclovir-resistant varicella zoster virus in an AIDS patient on prolonged acyclovir therapy

Analysis of the UL97 phosphotransferase coding sequence in clinical cytomegalovirus isolates and identification of mutations conferring ganciclovir resistance

Maribavir: A Novel Benzimidazole Ribonucleoside for the Prevention and Treatment of Cytomegalovirus Diseases

Single amino acid changes in the DNA polymerase confer foscarnet resistance and slow-growth phenotype, while mutations in the UL97-encoded phosphotransferase confer ganciclovir resistance in three double-resistant human cytomegalovirus strains recovered from patients with AIDS

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