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Singlicate analysis in regulated bioanalysis using ligand-binding assays: where are we heading?

Bioanalysis, 2017-09, Vol.9 (18), p.1357-1359

2017

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Subset analysis of patients experiencing clinical events of a potentially immunogenic nature in the pivotal clinical trials of tocilizumab for rheumatoid arthritis: Evaluation of an antidrug antibody ELISA using clinical adverse event-driven immunogenicity testing

Clinical therapeutics, 2010-08, Vol.32 (9), p.1597-1609

2010

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Antitumor activity of erlotinib (OSI-774, Tarceva) alone or in combination in human non-small cell lung cancer tumor xenograft models

Anti-cancer drugs, 2004-06, Vol.15 (5), p.503-512

2004

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Low immunogenicity of tocilizumab in patients with rheumatoid arthritis

Annals of the rheumatic diseases, 2017-06, Vol.76 (6), p.1078-1085

2017

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Pharmacokinetics and pharmacodynamics of the endothelin-receptor antagonist bosentan in healthy human subjects

Clinical pharmacology and therapeutics, 1996-08, Vol.60 (2), p.124-137

1996

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Effect of the Endothelin-Receptor Antagonist Bosentan on the Pharmacokinetics and Pharmacodynamics of Warfarin

Journal of clinical pharmacology, 1999-08, Vol.39 (8), p.847-854

1999

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Multiple-Dose Pharmacokinetics, Safety, and Tolerability of Bosentan, an Endothelin Receptor Antagonist, in Healthy Male Volunteers

Journal of clinical pharmacology, 1999-07, Vol.39 (7), p.703-714

1999

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Validation of a ligand-binding assay for active protein drug quantification following the 'free analyte QC concept'

Bioanalysis, 2016-12, Vol.9 (1), p.2537-2549

2016

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2017 White Paper on recent issues in bioanalysis: a global perspective on immunogenicity guidelines & biomarker assay performance (Part 3 - LBA: immunogenicity, biomarkers and PK assays)

Bioanalysis, 2017-12, Vol.9 (24), p.1967-1996

2017

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Subcutaneous versus intravenous administration of rituximab: pharmacokinetics, CD20 target coverage and B-cell depletion in cynomolgus monkeys

PloS one, 2013-11, Vol.8 (11), p.e80533

2013

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2015 White Paper on recent issues in bioanalysis: focus on new technologies and biomarkers (Part 3--LBA, biomarkers and immunogenicity)

Bioanalysis, 2015-12, Vol.7 (24), p.3107-3124

2015

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2016 White Paper on recent issues in bioanalysis: focus on biomarker assay validation (BAV): (Part 3 - LBA, biomarkers and immunogenicity)

Bioanalysis, 2016-12, Vol.8 (23), p.2475-2496

2016

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Comparison of B Cell Depletion Mediated by Intravenous (IV) Rituxan® and Rituxan Given Subcutaneous (SC) In Cynomolgus Monkeys

Blood, 2010-11, Vol.116 (21), p.3980-3980

2010

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Lack of Interaction between Tolcapone and Tolbutamide in Healthy Volunteers

Journal of clinical pharmacology, 2000-05, Vol.40 (5), p.544-551

2000

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In vivo and in vitro characterization of ethyl methanesulfonate pharmacokinetics in animals and in human

Toxicology letters, 2009-11, Vol.190 (3), p.303-309

2009

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The effect of bosentan on the pharmacokinetics of digoxin in healthy male subjects

British journal of clinical pharmacology, 1999-06, Vol.47 (6), p.701-706

1999

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Lack of Interaction between Tolcapone and Tolbutamide in Healthy Volunteers

Journal of clinical pharmacology, 2000-05, Vol.40 (5), p.544-551

2000

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Multiple-Dose Pharmacokinetics, Safety, and Tolerability of Bosentan, an Endothelin Receptor Antagonist, in Healthy Male Volunteers

Journal of clinical pharmacology, 1999-07, Vol.39 (7), p.703-714

1999

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Computerized determination of growth kinetic curves and doubling times from cells in microculture

Analytical biochemistry, 1990-06, Vol.187 (2), p.262-267

1990

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Sulfate derivatives of 2-phenylindols as novel steroid sulfatase inhibitors: An in vitro study on structure-activity-relationship

Biochemical pharmacology, 1990-01, Vol.39 (11), p.1709-1713

1990

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Synthesis and Biological Properties of a 1-(6-Aziridinylhexyl)-2-phenylindole, a Potential Fluorescence Label for Estrogen Receptors

Archiv der Pharmazie (Weinheim), 1990, Vol.323 (8), p.459-463

1990

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Singlicate analysis in regulated bioanalysis using ligand-binding assays: where are we heading?

Subset analysis of patients experiencing clinical events of a potentially immunogenic nature in the pivotal clinical trials of tocilizumab for rheumatoid arthritis: Evaluation of an antidrug antibody ELISA using clinical adverse event-driven immunogenicity testing

Antitumor activity of erlotinib (OSI-774, Tarceva) alone or in combination in human non-small cell lung cancer tumor xenograft models

Low immunogenicity of tocilizumab in patients with rheumatoid arthritis

Pharmacokinetics and pharmacodynamics of the endothelin-receptor antagonist bosentan in healthy human subjects

Effect of the Endothelin-Receptor Antagonist Bosentan on the Pharmacokinetics and Pharmacodynamics of Warfarin

Multiple-Dose Pharmacokinetics, Safety, and Tolerability of Bosentan, an Endothelin Receptor Antagonist, in Healthy Male Volunteers

Validation of a ligand-binding assay for active protein drug quantification following the 'free analyte QC concept'

2017 White Paper on recent issues in bioanalysis: a global perspective on immunogenicity guidelines & biomarker assay performance (Part 3 - LBA: immunogenicity, biomarkers and PK assays)

Subcutaneous versus intravenous administration of rituximab: pharmacokinetics, CD20 target coverage and B-cell depletion in cynomolgus monkeys

2015 White Paper on recent issues in bioanalysis: focus on new technologies and biomarkers (Part 3--LBA, biomarkers and immunogenicity)

2016 White Paper on recent issues in bioanalysis: focus on biomarker assay validation (BAV): (Part 3 - LBA, biomarkers and immunogenicity)

Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration

Comparison of B Cell Depletion Mediated by Intravenous (IV) Rituxan® and Rituxan Given Subcutaneous (SC) In Cynomolgus Monkeys

Lack of Interaction between Tolcapone and Tolbutamide in Healthy Volunteers

In vivo and in vitro characterization of ethyl methanesulfonate pharmacokinetics in animals and in human

The effect of bosentan on the pharmacokinetics of digoxin in healthy male subjects

Lack of Interaction between Tolcapone and Tolbutamide in Healthy Volunteers

Multiple-Dose Pharmacokinetics, Safety, and Tolerability of Bosentan, an Endothelin Receptor Antagonist, in Healthy Male Volunteers

Computerized determination of growth kinetic curves and doubling times from cells in microculture

Sulfate derivatives of 2-phenylindols as novel steroid sulfatase inhibitors: An in vitro study on structure-activity-relationship

Synthesis and Biological Properties of a 1-(6-Aziridinylhexyl)-2-phenylindole, a Potential Fluorescence Label for Estrogen Receptors

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