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Accelerating BRPF1b hit identification with BioPhysical and Active Learning Screening (BioPALS)

ChemMedChem, 2024-03, Vol.19 (6), p.e202300590-n/a

2024

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Ring-Closing Metathesis as a Basis for the Construction of Aromatic Compounds

Angewandte Chemie (International ed.), 2006-04, Vol.45 (17), p.2664-2670

2006

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1504 Epithelial to mesenchymal transition (EMT) can be driven by macrophages through multiple signalling pathways

Journal for immunotherapy of cancer, 2023-11, Vol.11 (Suppl 1), p.A1668-A1668

2023

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Preface

Progress in medicinal chemistry, 2023-01, Vol.62, p.ix-x

2023

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Flexible metathesis-based approaches to highly functionalised furans and pyrroles

Tetrahedron, 2008-01, Vol.64 (5), p.809-820

2008

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A Simple Route to Functionalized Δ1-Pyrrolenines

Heterocycles, 2014, Vol.88 (2), p.953-960

2014

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Drug discovery for psychiatric disorders

1, 2012

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Biophysical screening and characterisation in medicinal chemistry

Progress in medicinal chemistry, 2023, Vol.62, p.61-104

2023

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Transporters as Targets for Drugs

1. Aufl., 2009

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Abstract A122: Deciphering macrophage targeting cancer immunotherapies using a novel in vitro assay modelling the tumor microenvironment

Molecular cancer therapeutics, 2023-12, Vol.22 (12_Supplement), p.A122-A122

2023

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Abstract 3764: Porcupine inhibitor RXC004 enhances immune response in pre-clinical models of cancer

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.3764-3764

2018

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Novel C-7 carbon substituted fourth generation fluoroquinolones targeting N. Gonorrhoeae infections

Bioorganic & medicinal chemistry letters, 2020-10, Vol.30 (20), p.127428-127428, Article 127428

2020

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Novel porcupine (PORCN) inhibitor RXC004: Evaluation in models of RNF43 loss of function cancers

Journal of clinical oncology, 2017-05, Vol.35 (15_suppl), p.e14094-e14094

2017

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Development of an organo- and enzyme-catalysed one-pot, sequential three-component reaction

Tetrahedron, 2012-09, Vol.68 (37), p.7719-7722

2012

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Abstract A199: Development of a series of novel, potent and selective inhibitors of cFMS as a potential treatment for CSF1 expressing cancers via the modulation of the tumor microenvironment and the repolarization of macrophages

Molecular cancer therapeutics, 2015-12, Vol.14 (12_Supplement_2), p.A199-A199

2015

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Abstract 5581: Development of 2nd generation indoleamine 2,3-dioxygenase 1 (IDO1) selective inhibitors

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.5581-5581

2017

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The Wnt Pathway Inhibitor RXC004 Blocks Tumor Growth and Reverses Immune Evasion in Wnt Ligand-dependent Cancer Models

Cancer research communications, 2022-09, Vol.2 (9), p.914-928

2022

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Abstract 5160: Development of REDX05358, a novel highly selective and potent pan RAF inhibitor and a potential therapeutic for BRAF and RAS mutant tumors

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.5160-5160

2017

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Abstract 4795: Development of novel, selective, reversible inhibitors equipotent against wild-type and C481S Bruton's tyrosine kinase (BTK)

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.4795-4795

2016

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Abstract 419: The development of BRPF1 degraders as a potential treatment for acute myeloid leukemia

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.419-419

2022

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CHAPTER 18 - Medicinal Chemistry Challenges in CNS Drug Discovery

Drug Discovery for Psychiatric Disorders, 2012, p.465-509

2012

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Development of REDX05194, a Novel, Potent and Selective Inhibitor of Bruton's Tyrosine Kinase (BTK) As a Potential Treatment for B-Cell Malignancies

Blood, 2015-12, Vol.126 (23), p.4848-4848

2015

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A Metathesis Approach to Aromatic Heterocycles

European Journal of Organic Chemistry, 2005-05, Vol.2005 (10), p.1969-1971

2005

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A study of some molecularly imprinted polymers as protic catalysts for the isomerisation of α-pinene oxide to trans-carveol

Tetrahedron, 2004-03, Vol.60 (14), p.3231-3241

2004

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Accelerating BRPF1b hit identification with BioPhysical and Active Learning Screening (BioPALS)

Ring-Closing Metathesis as a Basis for the Construction of Aromatic Compounds

1504 Epithelial to mesenchymal transition (EMT) can be driven by macrophages through multiple signalling pathways

Preface

Flexible metathesis-based approaches to highly functionalised furans and pyrroles

A Simple Route to Functionalized Δ1-Pyrrolenines

Drug discovery for psychiatric disorders

Biophysical screening and characterisation in medicinal chemistry

Transporters as Targets for Drugs

Abstract A122: Deciphering macrophage targeting cancer immunotherapies using a novel in vitro assay modelling the tumor microenvironment

Abstract 3764: Porcupine inhibitor RXC004 enhances immune response in pre-clinical models of cancer

Novel C-7 carbon substituted fourth generation fluoroquinolones targeting N. Gonorrhoeae infections

Novel porcupine (PORCN) inhibitor RXC004: Evaluation in models of RNF43 loss of function cancers

Development of an organo- and enzyme-catalysed one-pot, sequential three-component reaction

Abstract A199: Development of a series of novel, potent and selective inhibitors of cFMS as a potential treatment for CSF1 expressing cancers via the modulation of the tumor microenvironment and the repolarization of macrophages

Abstract 5581: Development of 2nd generation indoleamine 2,3-dioxygenase 1 (IDO1) selective inhibitors

The Wnt Pathway Inhibitor RXC004 Blocks Tumor Growth and Reverses Immune Evasion in Wnt Ligand-dependent Cancer Models

Abstract 5160: Development of REDX05358, a novel highly selective and potent pan RAF inhibitor and a potential therapeutic for BRAF and RAS mutant tumors

Abstract 4795: Development of novel, selective, reversible inhibitors equipotent against wild-type and C481S Bruton's tyrosine kinase (BTK)

Abstract 419: The development of BRPF1 degraders as a potential treatment for acute myeloid leukemia

CHAPTER 18 - Medicinal Chemistry Challenges in CNS Drug Discovery

Development of REDX05194, a Novel, Potent and Selective Inhibitor of Bruton's Tyrosine Kinase (BTK) As a Potential Treatment for B-Cell Malignancies

REDX08608, a Novel, Potent and Selective, Reversible BTK Inhibitor with Efficacy and Equivalent Potency Against Wild-Type and Mutant C481S BTK

A Metathesis Approach to Aromatic Heterocycles

A study of some molecularly imprinted polymers as protic catalysts for the isomerisation of α-pinene oxide to trans-carveol

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