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2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity

Science translational medicine, 2017-02, Vol.9 (375)

2017

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Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair

Nature genetics, 2018-08, Vol.50 (8), p.1086-1092

2018

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Residual Convolutional Neural Network for the Determination of IDH Status in Low- and High-Grade Gliomas from MR Imaging

Clinical cancer research, 2018-03, Vol.24 (5), p.1073-1081

2018

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PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma

Nature communications, 2019-08, Vol.10 (1), p.3790-10, Article 3790

2019

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Mismatch repair proteins play a role in ATR activation upon temozolomide treatment in MGMT-methylated glioblastoma

Scientific reports, 2022-04, Vol.12 (1), p.5827-5827, Article 5827

2022

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Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130

Proceedings of the National Academy of Sciences - PNAS, 2010-02, Vol.107 (5), p.2201-2206

2010

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Loss of ATRX confers DNA repair defects and PARP inhibitor sensitivity

Translational oncology, 2021-09, Vol.14 (9), p.101147-101147, Article 101147

2021

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Microcephalin 1/BRIT1-TRF2 interaction promotes telomere replication and repair, linking telomere dysfunction to primary microcephaly

Nature communications, 2020-11, Vol.11 (1), p.5861-5861, Article 5861

2020

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Regulation of DNA repair in hypoxic cancer cells

Cancer and metastasis reviews, 2007-06, Vol.26 (2), p.249-260

2007

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Role of Radiation Therapy in the Management of Diffuse Intrinsic Pontine Glioma: A Systematic Review

Advances in radiation oncology, 2019-07, Vol.4 (3), p.520-531

2019

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Adjuvant chemotherapy and overall survival in adult medulloblastoma

Neuro-oncology (Charlottesville, Va.), 2017-02, Vol.19 (2), p.259-269

2017

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CDKN2A Copy Number Loss Is an Independent Prognostic Factor in HPV-Negative Head and Neck Squamous Cell Carcinoma

Frontiers in oncology, 2018-04, Vol.8, p.95-95

2018

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Hypoxia-induced down-regulation of BRCA1 expression by E2Fs

Cancer research (Chicago, Ill.), 2005-12, Vol.65 (24), p.11597-11604

2005

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Co-repression of mismatch repair gene expression by hypoxia in cancer cells: Role of the Myc/Max network

Cancer letters, 2007-07, Vol.252 (1), p.93-103

2007

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Targeting the DNA damage response for cancer therapy

DNA repair, 2009-09, Vol.8 (9), p.1153-1165

2009

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Down-Regulation of Rad51 and Decreased Homologous Recombination in Hypoxic Cancer Cells

Molecular and Cellular Biology, 2004-10, Vol.24 (19), p.8504-8518

2004

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Targeting IDH1/2 mutant cancers with combinations of ATR and PARP inhibitors

NAR cancer, 2021-06, Vol.3 (2)

2021

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Delayed Cerebral Vasculopathy Following Cranial Radiation Therapy for Pediatric Tumors

Pediatric neurology, 2014-06, Vol.50 (6), p.549-556

2014

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Hypoxia-induced genetic instability--a calculated mechanism underlying tumor progression

Journal of molecular medicine (Berlin, Germany), 2007-02, Vol.85 (2), p.139-148

2007

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Penetrating the brain tumor space with DNA damage response inhibitors

Neuro-oncology (Charlottesville, Va.), 2020-12, Vol.22 (12), p.1718-1720

Bindra, Ranjit S

2020

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Oncometabolites suppress DNA repair by disrupting local chromatin signalling

Nature (London), 2020-06, Vol.582 (7813), p.586-591

2020

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Postoperative Radiotherapy Patterns of Care and Survival Implications for Medulloblastoma in Young Children

JAMA oncology, 2016-12, Vol.2 (12), p.1574

2016

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Decreased Expression of the DNA Mismatch Repair Gene Mlh1 under Hypoxic Stress in Mammalian Cells

Molecular and Cellular Biology, 2003-05, Vol.23 (9), p.3265-3273

2003

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Mechanism-based design of agents that selectively target drug-resistant glioma

Science (American Association for the Advancement of Science), 2022-07, Vol.377 (6605), p.502-511

2022

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Intrathecal delivery and its applications in leptomeningeal disease

Advanced drug delivery reviews, 2022-07, Vol.186, p.114338-114338, Article 114338

2022

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2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity

Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair

Residual Convolutional Neural Network for the Determination of IDH Status in Low- and High-Grade Gliomas from MR Imaging

PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma

Mismatch repair proteins play a role in ATR activation upon temozolomide treatment in MGMT-methylated glioblastoma

Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130

Loss of ATRX confers DNA repair defects and PARP inhibitor sensitivity

Microcephalin 1/BRIT1-TRF2 interaction promotes telomere replication and repair, linking telomere dysfunction to primary microcephaly

Regulation of DNA repair in hypoxic cancer cells

Role of Radiation Therapy in the Management of Diffuse Intrinsic Pontine Glioma: A Systematic Review

Adjuvant chemotherapy and overall survival in adult medulloblastoma

CDKN2A Copy Number Loss Is an Independent Prognostic Factor in HPV-Negative Head and Neck Squamous Cell Carcinoma

Hypoxia-induced down-regulation of BRCA1 expression by E2Fs

Co-repression of mismatch repair gene expression by hypoxia in cancer cells: Role of the Myc/Max network

Targeting the DNA damage response for cancer therapy

Down-Regulation of Rad51 and Decreased Homologous Recombination in Hypoxic Cancer Cells

Targeting IDH1/2 mutant cancers with combinations of ATR and PARP inhibitors

Delayed Cerebral Vasculopathy Following Cranial Radiation Therapy for Pediatric Tumors

Hypoxia-induced genetic instability--a calculated mechanism underlying tumor progression

Penetrating the brain tumor space with DNA damage response inhibitors

Oncometabolites suppress DNA repair by disrupting local chromatin signalling

Postoperative Radiotherapy Patterns of Care and Survival Implications for Medulloblastoma in Young Children

Decreased Expression of the DNA Mismatch Repair Gene Mlh1 under Hypoxic Stress in Mammalian Cells

Mechanism-based design of agents that selectively target drug-resistant glioma

Intrathecal delivery and its applications in leptomeningeal disease

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