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Seocalcitol (EB 1089): a vitamin D analogue of anti-cancer potential. Background, design, synthesis, pre-clinical and clinical evaluation

Current pharmaceutical design, 2000-05, Vol.6 (7), p.803-828

2000

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20-epi-vitamin D3 analogues : a novel class of potent regulators of cell growth and immune responses

Biochemical pharmacology, 1991-09, Vol.42 (8), p.1569-1575

1991

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EB1627: a soluble prodrug of the potent anticancer cyanoguanidine CHS828

Bioorganic & medicinal chemistry letters, 2005-05, Vol.15 (10), p.2491-2494

2005

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Metabolism of the vitamin D 3 analogue EB1089 alters receptor complex formation and reduces promoter selectivity

British journal of pharmacology, 2009-02, Vol.125 (4), p.607-614

2009

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Chemistry and Biology of 23-oxa-aro- and 23-thia-aro-Vitamin D Analogues with High Antiproliferative and Low Calcemic Activity

Vitamin D, 2020, p.75-76

2020

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An Efficient Synthesis of a Key Intermediate for the Biologically Active Vitamin D Analogue, Seocalcitol

Organic process research & development, 2004-01, Vol.8 (1), p.133-135

2004

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THE 20-EPI MODIFICATION IN THE VITAMIN D SERIES: SELECTIVE ENHANCEMENT OF "NON-CLASSICAL" RECEPTOR-MEDIATED EFFECTS

Vitamin D, 2019, p.163-164

Originally published 1991, 2019

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SYNTHESIS AND BIOLOGICAL ACTIVITY OF 1a-HYDROXYLATED VITAMIN D ANALOGUES WITH POLY-UNSATURATED SIDE CHAINS

Vitamin D, 2019, p.192-193

Originally published 1991, 2019

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Metabolism of the vitamin D analog EB 1089: Identification of in vivo and in vitro liver metabolites and their biological activities

Biochemical pharmacology, 1997-04, Vol.53 (8), p.1087-1097

1997

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Chlorosulfates as Reagents in the Synthesis of Carboxylic Acid Esters Under Phase-Transfer Conditions

Synthetic communications, 1984-07, Vol.14 (9), p.857-864

1984

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Synthesis of tritium labelled CHS 828 and its prodrug EB 1627

Journal of labelled compounds & radiopharmaceuticals, 2005-10, Vol.48 (11), p.789-795

2005

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The synthesis of [26,27- 11C]dihydroxyvitamin D 3, a tracer for positron emission tomography (PET)

Bioorganic & medicinal chemistry, 2001-12, Vol.9 (12), p.3123-3128

2001

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Metabolism of the vitamin D analog EB1089 by cultured human cells: redirection of hydroxylation site to distal carbons of the side-chain

Biochemical pharmacology, 1997-03, Vol.53 (6), p.783-793

1997

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The synthesis of [26,27-11C]dihydroxyvitamin D(3), a tracer for positron emission tomography (PET)

Bioorganic & medicinal chemistry, 2001-12, Vol.9 (12), p.3123-3128

2001

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Examination of structurally selective derivatization of vitamin D(3) analogues by electrospray mass spectrometry

Journal of mass spectrometry., 2001-01, Vol.36 (1), p.71

2001

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Polyclonal antibodies to EB1089 (seocalcitol), an analog of 1α,25-dihydroxyvitamin D 3

Steroids, 2001-07, Vol.66 (7), p.539-548

2001

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Mutual pro-drugs of beta-lactam antibiotics and beta-lactamase inhibitors

Journal of antibiotics, 1980-01, Vol.33 (10), p.1183-1192

1980

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The vitamin D analog, KH1060, is rapidly degraded both in vivo and in vitro via several pathways: principal metabolites generated retain significant biological activity

Endocrinology (Philadelphia), 1997-12, Vol.138 (12), p.5485-5496

1997

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Polyclonal antibodies to EB1089 (seocalcitol), an analog of 1alpha,25-dihydroxyvitamin D(3)

Steroids, 2001-07, Vol.66 (7), p.539-548

2001

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Structural variants of the vitamin D analogue EB1089 reduce its ligand sensitivity and promoter selectivity

Journal of cellular biochemistry, 1998-12, Vol.71 (3), p.340-350

1998

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Disodium 1‐hydroxy‐3‐(1‐pyrrolidinyl)‐propylidene‐1,1‐bisphosphonate (EB‐1053) is a potent inhibitor of bone resorption in vitro and in vivo

Journal of bone and mineral research, 1992-08, Vol.7 (8), p.981-986

1992

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ORALLY ACTIVE CEPHALOGLYCIN ESTERS

The Journal of Antibiotics, 1971, Vol.24(11), pp.767-773

1971

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Metabolism of the vitamin D3 analogue EB1089 alters receptor complex formation and reduces promoter selectivity

British journal of pharmacology, 1998-10, Vol.125 (4), p.607-614

1998

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Calcipotriol

Drugs of the future, 1990, Vol.15 (1), p.15

Binderup, E.

1990

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The Decomposition of 4,4-Dialkylsubstituted Thiosemicarbazides

Acta chemica Scandinavica (Copenhagen. 1989), 1967, Vol.21, p.1984-1986

1967

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Seocalcitol (EB 1089): a vitamin D analogue of anti-cancer potential. Background, design, synthesis, pre-clinical and clinical evaluation

20-epi-vitamin D3 analogues : a novel class of potent regulators of cell growth and immune responses

EB1627: a soluble prodrug of the potent anticancer cyanoguanidine CHS828

Metabolism of the vitamin D 3 analogue EB1089 alters receptor complex formation and reduces promoter selectivity

Chemistry and Biology of 23-oxa-aro- and 23-thia-aro-Vitamin D Analogues with High Antiproliferative and Low Calcemic Activity

An Efficient Synthesis of a Key Intermediate for the Biologically Active Vitamin D Analogue, Seocalcitol

THE 20-EPI MODIFICATION IN THE VITAMIN D SERIES: SELECTIVE ENHANCEMENT OF "NON-CLASSICAL" RECEPTOR-MEDIATED EFFECTS

SYNTHESIS AND BIOLOGICAL ACTIVITY OF 1a-HYDROXYLATED VITAMIN D ANALOGUES WITH POLY-UNSATURATED SIDE CHAINS

Metabolism of the vitamin D analog EB 1089: Identification of in vivo and in vitro liver metabolites and their biological activities

Chlorosulfates as Reagents in the Synthesis of Carboxylic Acid Esters Under Phase-Transfer Conditions

Synthesis of tritium labelled CHS 828 and its prodrug EB 1627

The synthesis of [26,27- 11C]dihydroxyvitamin D 3, a tracer for positron emission tomography (PET)

Metabolism of the vitamin D analog EB1089 by cultured human cells: redirection of hydroxylation site to distal carbons of the side-chain

The synthesis of [26,27-11C]dihydroxyvitamin D(3), a tracer for positron emission tomography (PET)

Examination of structurally selective derivatization of vitamin D(3) analogues by electrospray mass spectrometry

Polyclonal antibodies to EB1089 (seocalcitol), an analog of 1α,25-dihydroxyvitamin D 3

Mutual pro-drugs of beta-lactam antibiotics and beta-lactamase inhibitors

The vitamin D analog, KH1060, is rapidly degraded both in vivo and in vitro via several pathways: principal metabolites generated retain significant biological activity

Polyclonal antibodies to EB1089 (seocalcitol), an analog of 1alpha,25-dihydroxyvitamin D(3)

Structural variants of the vitamin D analogue EB1089 reduce its ligand sensitivity and promoter selectivity

Disodium 1‐hydroxy‐3‐(1‐pyrrolidinyl)‐propylidene‐1,1‐bisphosphonate (EB‐1053) is a potent inhibitor of bone resorption in vitro and in vivo

ORALLY ACTIVE CEPHALOGLYCIN ESTERS

Metabolism of the vitamin D3 analogue EB1089 alters receptor complex formation and reduces promoter selectivity

Calcipotriol

The Decomposition of 4,4-Dialkylsubstituted Thiosemicarbazides

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