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Fragment‐based drug discovery—the importance of high‐quality molecule libraries

Molecular oncology, 2022-11, Vol.16 (21), p.3761-3777

2022

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Cancer prevention and therapy through the modulation of the tumor microenvironment

Seminars in cancer biology, 2015-12, Vol.35 (Suppl), p.S199-S223

2015

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Automated Generation of Novel Fragments Using Screening Data, a Dual SMILES Autoencoder, Transfer Learning and Syntax Correction

Journal of chemical information and modeling, 2021-06, Vol.61 (6), p.2547-2559

2021

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Implementation of an AI-assisted fragment-generator in an open-source platform

RSC medicinal chemistry, 2022-10, Vol.13 (1), p.125-1211

2022

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Reactivity of Covalent Fragments and Their Role in Fragment Based Drug Discovery

Pharmaceuticals (Basel, Switzerland), 2022-11, Vol.15 (11), p.1366

2022

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A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds

PLoS genetics, 2017-08, Vol.13 (8), p.e1006942

2017

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A matrisome RNA signature from early-pregnancy mouse mammary fibroblasts predicts distant metastasis-free breast cancer survival in humans

Breast cancer research : BCR, 2021-09, Vol.23 (1), p.90-90, Article 90

2021

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A Novel Pyrazolopyrimidine Ligand of Human PGK1 and Stress Sensor DJ1 Modulates the Shelterin Complex and Telomere Length Regulation

Neoplasia (New York, N.Y.), 2019-09, Vol.21 (9), p.893-907

2019

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Mathematical model of a telomerase transcriptional regulatory network developed by cell-based screening: analysis of inhibitor effects and telomerase expression mechanisms

PLoS computational biology, 2014-02, Vol.10 (2), p.e1003448

2014

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Identification of a Selective G1-Phase Benzimidazolone Inhibitor by a Senescence-Targeted Virtual Screen Using Artificial Neural Networks

Neoplasia (New York, N.Y.), 2015-09, Vol.17 (9), p.704-715

2015

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Therapeutic targeting of replicative immortality

Seminars in cancer biology, 2015-12, Vol.35 (S), p.S104-S128

2015

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Dynamic telomerase gene suppression via network effects of GSK3 inhibition

PloS one, 2009-07, Vol.4 (7), p.e6459

2009

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Cancer cell senescence: a new frontier in drug development

Drug discovery today, 2012-03, Vol.17 (5-6), p.269-276

2012

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Targeting the telomere and shelterin complex for cancer therapy: current views and future perspectives

Journal of cellular and molecular medicine, 2011-02, Vol.15 (2), p.179-186

2011

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MicroRNA and senescence: the senectome, integration and distributed control

Critical reviews in oncogenesis, 2013, Vol.18 (4), p.373

2013

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Virotherapy: cancer gene therapy at last? [version 1; peer review: 2 approved]

F1000 research, 2016, Vol.5, p.2105

2016

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Modulation of telomerase promoter tumor selectivity in the context of oncolytic adenoviruses

Cancer research (Chicago, Ill.), 2007-02, Vol.67 (3), p.1299-1307

2007

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Transcriptional repression of telomerase RNA gene expression by c-Jun-NH2-kinase and Sp1/Sp3

Cancer research (Chicago, Ill.), 2006-02, Vol.66 (3), p.1363-1370

2006

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Selective ablation of human cancer cells by telomerase-specific adenoviral suicide gene therapy vectors expressing bacterial nitroreductase

Oncogene, 2003-01, Vol.22 (3), p.370-380

2003

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TCEAL7 Inhibition of c-Myc Activity in Alternative Lengthening of Telomeres Regulates hTERT Expression

Neoplasia (New York, N.Y.), 2010-05, Vol.12 (5), p.405,IN6-414,IN6

2010

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Fragment‐based drug discovery—the importance of high‐quality molecule libraries

Cancer prevention and therapy through the modulation of the tumor microenvironment

Automated Generation of Novel Fragments Using Screening Data, a Dual SMILES Autoencoder, Transfer Learning and Syntax Correction

Implementation of an AI-assisted fragment-generator in an open-source platform

Reactivity of Covalent Fragments and Their Role in Fragment Based Drug Discovery

Sustained proliferation in cancer: Mechanisms and novel therapeutic targets

Broad targeting of resistance to apoptosis in cancer

Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition

A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds

A matrisome RNA signature from early-pregnancy mouse mammary fibroblasts predicts distant metastasis-free breast cancer survival in humans

A Novel Pyrazolopyrimidine Ligand of Human PGK1 and Stress Sensor DJ1 Modulates the Shelterin Complex and Telomere Length Regulation

A multi-targeted approach to suppress tumor-promoting inflammation

Mathematical model of a telomerase transcriptional regulatory network developed by cell-based screening: analysis of inhibitor effects and telomerase expression mechanisms

Evasion of anti-growth signaling: A key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds

Identification of a Selective G1-Phase Benzimidazolone Inhibitor by a Senescence-Targeted Virtual Screen Using Artificial Neural Networks

Therapeutic targeting of replicative immortality

Dynamic telomerase gene suppression via network effects of GSK3 inhibition

Cancer cell senescence: a new frontier in drug development

Targeting the telomere and shelterin complex for cancer therapy: current views and future perspectives

MicroRNA and senescence: the senectome, integration and distributed control

Virotherapy: cancer gene therapy at last? [version 1; peer review: 2 approved]

Modulation of telomerase promoter tumor selectivity in the context of oncolytic adenoviruses

Transcriptional repression of telomerase RNA gene expression by c-Jun-NH2-kinase and Sp1/Sp3

Selective ablation of human cancer cells by telomerase-specific adenoviral suicide gene therapy vectors expressing bacterial nitroreductase

TCEAL7 Inhibition of c-Myc Activity in Alternative Lengthening of Telomeres Regulates hTERT Expression

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