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Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

Nature reviews. Drug discovery, 2010-11, Vol.9 (11), p.883-897

2010

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Second generation S1P pathway modulators: Research strategies and clinical developments

Biochimica et biophysica acta, 2014-05, Vol.1841 (5), p.745-758

2014

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Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors

Nature chemical biology, 2009-06, Vol.5 (6), p.428-434

2009

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Pharmacological inhibition of RORγt suppresses the Th17 pathway and alleviates arthritis in vivo

PloS one, 2017-11, Vol.12 (11), p.e0188391-e0188391

2017

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Orally Active 7‑Substituted (4-Benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as Active-Site Inhibitors of Sphingosine 1‑Phosphate Lyase for the Treatment of Multiple Sclerosis

Journal of medicinal chemistry, 2014-06, Vol.57 (12), p.5074-5084

2014

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Phosphorylation of the Immunomodulatory Drug FTY720 by Sphingosine Kinases

The Journal of biological chemistry, 2003-11, Vol.278 (48), p.47408-47415

2003

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Brain penetration of the oral immunomodulatory drug FTY720 and its phosphorylation in the central nervous system during experimental autoimmune encephalomyelitis: consequences for mode of action in multiple sclerosis

The Journal of pharmacology and experimental therapeutics, 2007-11, Vol.323 (2), p.469-475

2007

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A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis

The Journal of experimental medicine, 2012-11, Vol.209 (12), p.2165-2181

2012

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Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720

Blood, 2006-02, Vol.107 (4), p.1454-1458

2006

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Interferon regulatory factor 5 and nuclear factor kappa‐B exhibit cooperating but also divergent roles in the regulation of pro‐inflammatory cytokines important for the development of TH1 and TH17 responses

The FEBS journal, 2018-08, Vol.285 (16), p.3097-3113

2018

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Sphingosine 1-Phosphate Produced by Sphingosine Kinase 2 Intrinsically Controls Platelet Aggregation In Vitro and In Vivo

Circulation research, 2015-07, Vol.117 (4), p.376-387

2015

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Synthesis of Borondipyrromethene (BODIPY)-Labeled Sphingosine Derivatives by Cross-metathesis Reaction

Journal of organic chemistry, 2007-03, Vol.72 (5), p.1842-1845

2007

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Partial deficiency of sphingosine-1-phosphate lyase confers protection in experimental autoimmune encephalomyelitis

PloS one, 2013-03, Vol.8 (3), p.e59630-e59630

2013

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Targeting Ceramide Metabolism with a Potent and Specific Ceramide Kinase Inhibitor

Molecular pharmacology, 2008-10, Vol.74 (4), p.925-932

2008

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Pharmacological Inhibition of Stearoyl CoA Desaturase in the Skin Induces Atrophy of the Sebaceous Glands

Journal of investigative dermatology, 2013-08, Vol.133 (8), p.2091-2094

2013

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2-Substituted 4-(Thio)chromenone 6-O-Sulfamates: Potent Inhibitors of Human Steroid Sulfatase

Journal of medicinal chemistry, 2002-09, Vol.45 (19), p.4310-4320

2002

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Sphingosine 1-phosphate phosphatase 2 is induced during inflammatory responses

Cellular signalling, 2007-04, Vol.19 (4), p.748-760

2007

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The role of sphingosine and ceramide kinases in inflammatory responses

Immunology letters, 2005-01, Vol.96 (2), p.175-185

2005

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Retinoic-acid-orphan-receptor-C inhibition suppresses Th17 cells and induces thymic aberrations

JCI insight, 2017-03, Vol.2 (5), p.e91127-e91127

2017

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Binding of pimecrolimus and tacrolimus to skin and plasma proteins: implications for systemic exposure after topical application

Drug metabolism and disposition, 2008-09, Vol.36 (9), p.1812-1818

2008

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Characterization of a ceramide kinase-like protein

Biochimica et biophysica acta, 2005-02, Vol.1687 (1), p.31-43

2005

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Early Activation of Sphingosine Kinase in Mast Cells and Recruitment to FcεRI Are Mediated by Its Interaction with Lyn Kinase

Molecular and Cellular Biology, 2004-10, Vol.24 (19), p.8765-8777

2004

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Ceramide kinase targeting and activity determined by its N-terminal pleckstrin homology domain

Biochemical and biophysical research communications, 2004-11, Vol.324 (4), p.1215-1219

2004

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Pimecrolimus permeates less than tacrolimus through normal, inflamed, or corticosteroid-pretreated skin

Experimental dermatology, 2005-10, Vol.14 (10), p.752-757

2005

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Ovalbumin-induced plasma interleukin-4 levels are reduced in ceramide kinase-deficient DO11.10 RAG1-/- mice

Lipids in health and disease, 2010-01, Vol.9 (1), p.1-1, Article 1

2010

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Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

Second generation S1P pathway modulators: Research strategies and clinical developments

Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors

Pharmacological inhibition of RORγt suppresses the Th17 pathway and alleviates arthritis in vivo

Orally Active 7‑Substituted (4-Benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as Active-Site Inhibitors of Sphingosine 1‑Phosphate Lyase for the Treatment of Multiple Sclerosis

Phosphorylation of the Immunomodulatory Drug FTY720 by Sphingosine Kinases

Brain penetration of the oral immunomodulatory drug FTY720 and its phosphorylation in the central nervous system during experimental autoimmune encephalomyelitis: consequences for mode of action in multiple sclerosis

A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis

Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720

Interferon regulatory factor 5 and nuclear factor kappa‐B exhibit cooperating but also divergent roles in the regulation of pro‐inflammatory cytokines important for the development of TH1 and TH17 responses

Sphingosine 1-Phosphate Produced by Sphingosine Kinase 2 Intrinsically Controls Platelet Aggregation In Vitro and In Vivo

Synthesis of Borondipyrromethene (BODIPY)-Labeled Sphingosine Derivatives by Cross-metathesis Reaction

Partial deficiency of sphingosine-1-phosphate lyase confers protection in experimental autoimmune encephalomyelitis

Targeting Ceramide Metabolism with a Potent and Specific Ceramide Kinase Inhibitor

Pharmacological Inhibition of Stearoyl CoA Desaturase in the Skin Induces Atrophy of the Sebaceous Glands

2-Substituted 4-(Thio)chromenone 6-O-Sulfamates: Potent Inhibitors of Human Steroid Sulfatase

Sphingosine 1-phosphate phosphatase 2 is induced during inflammatory responses

The role of sphingosine and ceramide kinases in inflammatory responses

Retinoic-acid-orphan-receptor-C inhibition suppresses Th17 cells and induces thymic aberrations

Binding of pimecrolimus and tacrolimus to skin and plasma proteins: implications for systemic exposure after topical application

Characterization of a ceramide kinase-like protein

Early Activation of Sphingosine Kinase in Mast Cells and Recruitment to FcεRI Are Mediated by Its Interaction with Lyn Kinase

Ceramide kinase targeting and activity determined by its N-terminal pleckstrin homology domain

Pimecrolimus permeates less than tacrolimus through normal, inflamed, or corticosteroid-pretreated skin

Ovalbumin-induced plasma interleukin-4 levels are reduced in ceramide kinase-deficient DO11.10 RAG1-/- mice

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