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Solid phase synthesis and SAR of small molecule agonists for the GPR40 receptor

Bioorganic & medicinal chemistry letters, 2007-03, Vol.17 (6), p.1584-1589

2007

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Potent, Selective, and Orally Efficacious Antagonists of Melanin-Concentrating Hormone Receptor 1

Journal of medicinal chemistry, 2006-11, Vol.49 (24), p.7095-7107

2006

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The discovery and optimization of pyrimidinone-containing MCH R1 antagonists

Bioorganic & medicinal chemistry letters, 2006-09, Vol.16 (18), p.4723-4727

2006

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Synthesis of Ultra-Short-Acting Neuromuscular Blocker GW 0430: A Remarkably Stereo- and Regioselective Synthesis of Mixed Tetrahydroisoquinolinium Chlorofumarates

Organic letters, 1999-12, Vol.1 (12), p.1993-1996

1999

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Bis- and Mixed-Tetrahydroisoquinolinium Chlorofumarates: New Ultra-Short-Acting Nondepolarizing Neuromuscular Blockers

Journal of medicinal chemistry, 1999-01, Vol.42 (2), p.206-209

1999

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Neuromuscular Blocking Activity and Therapeutic Potential of Mixed-Tetrahydroisoquinolinium Halofumarates and Halosuccinates in Rhesus Monkeys

Journal of medicinal chemistry, 2003-06, Vol.46 (12), p.2502-2515

2003

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α1-Adrenoceptor agonists: The identification of novel α1A Subtype selective 2'-heteroaryl-2-(phenoxymethyl)imidazolines

Bioorganic & medicinal chemistry letters, 2002-02, Vol.12 (3), p.471-475

2002

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2-(anilinomethyl)imidazolines as α1 adrenergic receptor agonists : α1a subtype selective 2'-heteroaryl compounds

Bioorganic & medicinal chemistry letters, 2003-03, Vol.13 (6), p.1183-1186

2003

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2-(Anilinomethyl)imidazolines as α1A adrenergic receptor agonists: 2'-heteroaryl and 2'-oxime ether series

Bioorganic & medicinal chemistry letters, 2002-02, Vol.12 (4), p.575-579

2002

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α1-Adrenoceptor activation: A comparison of 4-(anilinomethyl)imidazoles and 4-(phenoxymethyl)imidazoles to related 2-imidazolines

Bioorganic & medicinal chemistry letters, 2002-12, Vol.12 (23), p.3449-3452

2002

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2-(Anilinomethyl)imidazolines as α1 Adrenergic Receptor Agonists: the Discovery of α1 a Subtype Selective 2‘-Alkylsulfonyl-Substituted Analogues

Journal of medicinal chemistry, 2002-05, Vol.45 (11), p.2229-2239

2002

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Bis- and Mixed-Tetrahydroisoquinolinium Chlorofumarates: New Ultra-Short-Acting Nondepolarizing Neuromuscular Blockers

Journal of medicinal chemistry, 1999-03, Vol.42 (6), p.1114-1114

1999

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2-Acetylpyridine thiocarbonohydrazones. Potent inactivators of herpes simplex virus ribonucleotide reductase

Journal of medicinal chemistry, 1992-06, Vol.35 (12), p.2306-2314

1992

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Synthesis and biological activity of open-chain analogs of 5,6,7,8-tetrahydrofolic acid-potential antitumor agents

Journal of medicinal chemistry, 1992-04, Vol.35 (8), p.1399-1410

1992

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Thienyl and Thiazolyl Acyclic Analogs of 5-Deazatetrahydrofolic Acid

Journal of medicinal chemistry, 1994-06, Vol.37 (13), p.2112-2115

1994

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Inhibition of arabinose 5-phosphate isomerase. An approach to the inhibition of bacterial lipopolysaccharide biosynthesis

Journal of medicinal chemistry, 1984-06, Vol.27 (6), p.717-726

1984

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alpha(1)-Adrenoceptor agonists: the identification of novel alpha(1A )subtype selective 2'-heteroaryl-2-(phenoxymethyl)imidazolines

Bioorganic & medicinal chemistry letters, 2002-02, Vol.12 (3), p.471-475

2002

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Alpha(1)-adrenoceptor activation: a comparison of 4-(anilinomethyl)imidazoles and 4-(phenoxymethyl)imidazoles to related 2-imidazolines

Bioorganic & medicinal chemistry letters, 2002-12, Vol.12 (23), p.3449-3452

2002

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2-(Anilinomethyl)imidazolines as alpha1 adrenergic receptor agonists: alpha1a subtype selective 2'-heteroaryl compounds

Bioorganic & medicinal chemistry letters, 2003-03, Vol.13 (6), p.1183

2003

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2-(Anilinomethyl)imidazolines as alpha1 adrenergic receptor agonists: the discovery of alpha1a subtype selective 2'-alkylsulfonyl-substituted analogues

Journal of medicinal chemistry, 2002-05, Vol.45 (11), p.2229-2239

2002

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2-(Anilinomethyl)imidazolines as α 1 Adrenergic Receptor Agonists: the Discovery of α 1 a Subtype Selective 2‘-Alkylsulfonyl-Substituted Analogues

Journal of medicinal chemistry, 2002-05, Vol.45 (11), p.2229-2239

2002

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Thallium in organic synthesis. XXXII. Oxidative rearrangement of olefins using thallium(III) nitrate (TTN)

Journal of the American Chemical Society, 1973-05, Vol.95 (11), p.3635-3640

1973

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2-(Anilinomethyl)imidazolines as α 1 adrenergic receptor agonists: α 1a subtype selective 2′-heteroaryl compounds

Bioorganic & medicinal chemistry letters, 2003, Vol.13 (6), p.1183-1186

2003

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Thallium in organic synthesis. 45. Synthesis of aromatic fluorides

Journal of organic chemistry, 1977-01, Vol.42 (2), p.362-363

1977

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2-(anilinomethyl)imidazolines as alpha1A adrenergic receptor agonists: 2'-heteroaryl and 2'-oxime ether series

Bioorganic & medicinal chemistry letters, 2002-02, Vol.12 (4), p.575-579

2002

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Solid phase synthesis and SAR of small molecule agonists for the GPR40 receptor

Potent, Selective, and Orally Efficacious Antagonists of Melanin-Concentrating Hormone Receptor 1

The discovery and optimization of pyrimidinone-containing MCH R1 antagonists

Synthesis of Ultra-Short-Acting Neuromuscular Blocker GW 0430: A Remarkably Stereo- and Regioselective Synthesis of Mixed Tetrahydroisoquinolinium Chlorofumarates

Bis- and Mixed-Tetrahydroisoquinolinium Chlorofumarates: New Ultra-Short-Acting Nondepolarizing Neuromuscular Blockers

Neuromuscular Blocking Activity and Therapeutic Potential of Mixed-Tetrahydroisoquinolinium Halofumarates and Halosuccinates in Rhesus Monkeys

α1-Adrenoceptor agonists: The identification of novel α1A Subtype selective 2'-heteroaryl-2-(phenoxymethyl)imidazolines

2-(anilinomethyl)imidazolines as α1 adrenergic receptor agonists : α1a subtype selective 2'-heteroaryl compounds

2-(Anilinomethyl)imidazolines as α1A adrenergic receptor agonists: 2'-heteroaryl and 2'-oxime ether series

α1-Adrenoceptor activation: A comparison of 4-(anilinomethyl)imidazoles and 4-(phenoxymethyl)imidazoles to related 2-imidazolines

2-(Anilinomethyl)imidazolines as α1 Adrenergic Receptor Agonists: the Discovery of α1 a Subtype Selective 2‘-Alkylsulfonyl-Substituted Analogues

Bis- and Mixed-Tetrahydroisoquinolinium Chlorofumarates: New Ultra-Short-Acting Nondepolarizing Neuromuscular Blockers

2-Acetylpyridine thiocarbonohydrazones. Potent inactivators of herpes simplex virus ribonucleotide reductase

Synthesis and biological activity of open-chain analogs of 5,6,7,8-tetrahydrofolic acid-potential antitumor agents

Thienyl and Thiazolyl Acyclic Analogs of 5-Deazatetrahydrofolic Acid

Inhibition of arabinose 5-phosphate isomerase. An approach to the inhibition of bacterial lipopolysaccharide biosynthesis

alpha(1)-Adrenoceptor agonists: the identification of novel alpha(1A )subtype selective 2'-heteroaryl-2-(phenoxymethyl)imidazolines

Alpha(1)-adrenoceptor activation: a comparison of 4-(anilinomethyl)imidazoles and 4-(phenoxymethyl)imidazoles to related 2-imidazolines

2-(Anilinomethyl)imidazolines as alpha1 adrenergic receptor agonists: alpha1a subtype selective 2'-heteroaryl compounds

2-(Anilinomethyl)imidazolines as alpha1 adrenergic receptor agonists: the discovery of alpha1a subtype selective 2'-alkylsulfonyl-substituted analogues

2-(Anilinomethyl)imidazolines as α 1 Adrenergic Receptor Agonists: the Discovery of α 1 a Subtype Selective 2‘-Alkylsulfonyl-Substituted Analogues

Thallium in organic synthesis. XXXII. Oxidative rearrangement of olefins using thallium(III) nitrate (TTN)

2-(Anilinomethyl)imidazolines as α 1 adrenergic receptor agonists: α 1a subtype selective 2′-heteroaryl compounds

Thallium in organic synthesis. 45. Synthesis of aromatic fluorides

2-(anilinomethyl)imidazolines as alpha1A adrenergic receptor agonists: 2'-heteroaryl and 2'-oxime ether series

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