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beautiful cell: high-content screening in drug discovery

Analytical and bioanalytical chemistry, 2010-09, Vol.398 (1), p.219-226

Bickle, Marc

2010

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RNA buffers the phase separation behavior of prion-like RNA binding proteins

Science (American Association for the Advancement of Science), 2018-05, Vol.360 (6391), p.918-921

2018

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Endosomal escape of delivered mRNA from endosomal recycling tubules visualized at the nanoscale

The Journal of cell biology, 2022-02, Vol.221 (2), p.1

2022

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Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

Nature biotechnology, 2013-07, Vol.31 (7), p.638-646

2013

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The technology development studio of the MPI-CBG: an open access cell-based screening facility

Combinatorial chemistry & high throughput screening, 2014-05, Vol.17 (4), p.322-327

Bickle, Marc

2014

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Phenotype loss is associated with widespread divergence of the gene regulatory landscape in evolution

Nature communications, 2018-11, Vol.9 (1), p.4737-15, Article 4737

2018

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Gender, Contraceptives and Individual Metabolic Predisposition Shape a Healthy Plasma Lipidome

Scientific reports, 2016-06, Vol.6 (1), p.27710-27710, Article 27710

2016

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Modeling early pathophysiological phenotypes of diabetic retinopathy in a human inner blood-retinal barrier-on-a-chip

Nature communications, 2024-02, Vol.15 (1), p.1372-1372, Article 1372

2024

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Statistical integration of multi-omics and drug screening data from cell lines

PLoS computational biology, 2024-01, Vol.20 (1), p.e1011809-e1011809

2024

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Isogenic FUS-eGFP iPSC Reporter Lines Enable Quantification of FUS Stress Granule Pathology that Is Rescued by Drugs Inducing Autophagy

Stem cell reports, 2018-02, Vol.10 (2), p.375-389

2018

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Knocking out C9ORF72 Exacerbates Axonal Trafficking Defects Associated with Hexanucleotide Repeat Expansion and Reduces Levels of Heat Shock Proteins

Stem cell reports, 2020-03, Vol.14 (3), p.390-405

2020

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Viral Infections Exacerbate FUS-ALS Phenotypes in iPSC-Derived Spinal Neurons in a Virus Species-Specific Manner

Frontiers in cellular neuroscience, 2019-10, Vol.13, p.480-480

2019

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Selection and characterization of large collections of peptide aptamers through optimized yeast two-hybrid procedures

Nature protocols, 2006-08, Vol.1 (3), p.1066-1091

2006

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Axonal Lysosomal Assays for Characterizing the Effects of LRRK2 G2019S

Biology (Basel, Switzerland), 2024-01, Vol.13 (1), p.58

2024

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The Academic Pill: How Academia Contributes to Curing Diseases

SLAS discovery, 2019-03, Vol.24 (3), p.203-212

Bickle, Marc

2019

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Image analysis in high-content screening

Combinatorial chemistry & high throughput screening, 2009-11, Vol.12 (9), p.899-907

2009

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The Yeast Phosphatidylinositol Kinase Homolog TOR2 Activates RHO1 and RHO2 via the Exchange Factor ROM2

Cell, 1997-02, Vol.88 (4), p.531-542

1997

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Screening out irrelevant cell-based models of disease

Nature reviews. Drug discovery, 2016-11, Vol.15 (11), p.751-769

2016

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Multilineage communication regulates human liver bud development from pluripotency

Nature (London), 2017-06, Vol.546 (7659), p.533-538

2017

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Live-Cell High Content Screening in Drug Development

Methods in molecular biology (Clifton, N.J.), 2018, Vol.1683, p.149

2018

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Concerns, challenges and promises of high-content analysis of 3D cellular models

Nature reviews. Drug discovery, 2018-08, Vol.17 (8), p.606-606

2018

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Mesenchymal stromal cells improve transplanted islet survival and islet function in a syngeneic mouse model

Diabetologia, 2014-03, Vol.57 (3), p.522-531

2014

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A Conserved RhoGAP Limits M Phase Contractility and Coordinates with Microtubule Asters to Confine RhoA during Cytokinesis

Developmental cell, 2013-09, Vol.26 (5), p.496-510

2013

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3D high-content screening for the identification of compounds that target cells in dormant tumor spheroid regions

Experimental cell research, 2014-04, Vol.323 (1), p.131-143

2014

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beautiful cell: high-content screening in drug discovery

RNA buffers the phase separation behavior of prion-like RNA binding proteins

Endosomal escape of delivered mRNA from endosomal recycling tubules visualized at the nanoscale

Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

The technology development studio of the MPI-CBG: an open access cell-based screening facility

Phenotype loss is associated with widespread divergence of the gene regulatory landscape in evolution

Gender, Contraceptives and Individual Metabolic Predisposition Shape a Healthy Plasma Lipidome

Modeling early pathophysiological phenotypes of diabetic retinopathy in a human inner blood-retinal barrier-on-a-chip

Statistical integration of multi-omics and drug screening data from cell lines

Isogenic FUS-eGFP iPSC Reporter Lines Enable Quantification of FUS Stress Granule Pathology that Is Rescued by Drugs Inducing Autophagy

Knocking out C9ORF72 Exacerbates Axonal Trafficking Defects Associated with Hexanucleotide Repeat Expansion and Reduces Levels of Heat Shock Proteins

Viral Infections Exacerbate FUS-ALS Phenotypes in iPSC-Derived Spinal Neurons in a Virus Species-Specific Manner

Dual Inhibition of GSK3β and CDK5 Protects the Cytoskeleton of Neurons from Neuroinflammatory-Mediated Degeneration In Vitro and In Vivo

Selection and characterization of large collections of peptide aptamers through optimized yeast two-hybrid procedures

Axonal Lysosomal Assays for Characterizing the Effects of LRRK2 G2019S

The Academic Pill: How Academia Contributes to Curing Diseases

Image analysis in high-content screening

The Yeast Phosphatidylinositol Kinase Homolog TOR2 Activates RHO1 and RHO2 via the Exchange Factor ROM2

Screening out irrelevant cell-based models of disease

Multilineage communication regulates human liver bud development from pluripotency

Live-Cell High Content Screening in Drug Development

Concerns, challenges and promises of high-content analysis of 3D cellular models

Mesenchymal stromal cells improve transplanted islet survival and islet function in a syngeneic mouse model

A Conserved RhoGAP Limits M Phase Contractility and Coordinates with Microtubule Asters to Confine RhoA during Cytokinesis

3D high-content screening for the identification of compounds that target cells in dormant tumor spheroid regions

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