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Biomarker‐Informed Model‐Based Risk Assessment of Organic Anion Transporting Polypeptide 1B Mediated Drug‐Drug Interactions

Clinical pharmacology and therapeutics, 2022-02, Vol.111 (2), p.404-415

2022

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Mechanistic Determinants of Daprodustat Drug–Drug Interactions and Pharmacokinetics in Hepatic Dysfunction and Chronic Kidney Disease: Significance of OATP1B‐CYP2C8 Interplay

Clinical pharmacology and therapeutics, 2024-06, Vol.115 (6), p.1336-1345

2024

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Clopidogrel as a Perpetrator of Drug–Drug Interactions: A Challenge for Quantitative Predictions?

Clinical pharmacology and therapeutics, 2019-06, Vol.105 (6), p.1295-1299

2019

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Effect of Hepatic Organic Anion‐Transporting Polypeptide 1B Inhibition and Chronic Kidney Disease on the Pharmacokinetics of a Liver‐Targeted Glucokinase Activator: A Model‐Based Evaluation

Clinical pharmacology and therapeutics, 2019-10, Vol.106 (4), p.792-802

2019

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Quantitative prediction of transporter- and enzyme-mediated clinical drug-drug interactions of organic anion-transporting polypeptide 1B1 substrates using a mechanistic net-effect model

The Journal of pharmacology and experimental therapeutics, 2014-10, Vol.351 (1), p.214-223

2014

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Quantitative Contribution of Six Major Transporters to the Hepatic Uptake of Drugs: "SLC-Phenotyping" Using Primary Human Hepatocytes

The Journal of pharmacology and experimental therapeutics, 2019-07, Vol.370 (1), p.72-83

2019

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Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data

Drug metabolism and disposition, 2012-05, Vol.40 (5), p.1007-1017

2012

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Effect of Human Plasma on Hepatic Uptake of Organic Anion-Transporting Polypeptide 1B Substrates: Studies Using Transfected Cells and Primary Human Hepatocytes

Drug metabolism and disposition, 2021-01, Vol.49 (1), p.72-83

2021

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Hepatobiliary Clearance Prediction: Species Scaling From Monkey, Dog, and Rat, and In Vitro–In Vivo Extrapolation of Sandwich-Cultured Human Hepatocytes Using 17 Drugs

Journal of pharmaceutical sciences, 2017-09, Vol.106 (9), p.2795-2804

2017

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Organic Anion Transporter 2 Mediates Hepatic Uptake of Tolbutamide, a CYP2C9 Probe Drug

The Journal of pharmacology and experimental therapeutics, 2018-03, Vol.364 (3), p.390-398

2018

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Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro–In Vivo Scaling of Hepatic Uptake Clearance

Drug metabolism and disposition, 2018-07, Vol.46 (7), p.989-1000

2018

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Use of cryopreserved human hepatocytes in sandwich culture to measure hepatobiliary transport

Drug metabolism and disposition, 2006-09, Vol.34 (9), p.1658-1665

2006

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Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design

European journal of medicinal chemistry, 2012-11, Vol.57, p.441-448

2012

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Characterization of Organic Anion Transporting Polypeptide (OATP) Expression and Its Functional Contribution to the Uptake of Substrates in Human Hepatocytes

Molecular pharmaceutics, 2012-12, Vol.9 (12), p.3535-3542

2012

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Quantitative assessment of the contribution of sodium-dependent taurocholate co-transporting polypeptide (NTCP) to the hepatic uptake of rosuvastatin, pitavastatin and fluvastatin

Biopharmaceutics & drug disposition, 2013-11, Vol.34 (8), p.452-461

2013

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Leveraging of Rifampicin-Dosed Cynomolgus Monkeys to Identify Bile Acid 3-O-Sulfate Conjugates as Potential Novel Biomarkers for Organic Anion-Transporting Polypeptides

Drug metabolism and disposition, 2017-07, Vol.45 (7), p.721-733

2017

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Reliable Rate Measurements for Active and Passive Hepatic Uptake Using Plated Human Hepatocytes

The AAPS journal, 2017-05, Vol.19 (3), p.787-796

2017

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In Vitro–In Vivo Extrapolation of OATP1B-Mediated Drug–Drug Interactions in Cynomolgus Monkey

The Journal of pharmacology and experimental therapeutics, 2018-06, Vol.365 (3), p.688-699

2018

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Culture period-dependent changes in the uptake of transporter substrates in sandwich-cultured rat and human hepatocytes

Drug metabolism and disposition, 2011-09, Vol.39 (9), p.1503-1510

2011

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In vitro evaluation of hepatic transporter-mediated clinical drug-drug interactions: hepatocyte model optimization and retrospective investigation

Drug metabolism and disposition, 2012-06, Vol.40 (6), p.1085-1092

2012

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Quantitative prediction of repaglinide-rifampicin complex drug interactions using dynamic and static mechanistic models: delineating differential CYP3A4 induction and OATP1B1 inhibition potential of rifampicin

Drug metabolism and disposition, 2013-05, Vol.41 (5), p.966-974

2013

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Quantitative Expression Profile of Hepatobiliary Transporters in Sandwich Cultured Rat and Human Hepatocytes

Molecular pharmaceutics, 2009-08, Vol.6 (4), p.1180-1189

2009

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Characterization of digoxin uptake in sandwich-cultured human hepatocytes

Drug metabolism and disposition, 2011-01, Vol.39 (1), p.47-53

2011

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OATP1B-mediated hepatic uptake of low-molecular weight acid compounds: assessment of HIF prolyl-hydroxylase inhibitors (DUSTATS)

Drug metabolism and pharmacokinetics, 2024-04, Vol.55, p.100981, Article 100981

2024

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Role of Hepatic Transporters in the Disposition and Hepatotoxicity of a HER2 Tyrosine Kinase Inhibitor CP-724,714

Toxicological sciences, 2009-04, Vol.108 (2), p.492-500

2009

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Biomarker‐Informed Model‐Based Risk Assessment of Organic Anion Transporting Polypeptide 1B Mediated Drug‐Drug Interactions

Mechanistic Determinants of Daprodustat Drug–Drug Interactions and Pharmacokinetics in Hepatic Dysfunction and Chronic Kidney Disease: Significance of OATP1B‐CYP2C8 Interplay

Clopidogrel as a Perpetrator of Drug–Drug Interactions: A Challenge for Quantitative Predictions?

Effect of Hepatic Organic Anion‐Transporting Polypeptide 1B Inhibition and Chronic Kidney Disease on the Pharmacokinetics of a Liver‐Targeted Glucokinase Activator: A Model‐Based Evaluation

Quantitative prediction of transporter- and enzyme-mediated clinical drug-drug interactions of organic anion-transporting polypeptide 1B1 substrates using a mechanistic net-effect model

Quantitative Contribution of Six Major Transporters to the Hepatic Uptake of Drugs: "SLC-Phenotyping" Using Primary Human Hepatocytes

Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data

Effect of Human Plasma on Hepatic Uptake of Organic Anion-Transporting Polypeptide 1B Substrates: Studies Using Transfected Cells and Primary Human Hepatocytes

Hepatobiliary Clearance Prediction: Species Scaling From Monkey, Dog, and Rat, and In Vitro–In Vivo Extrapolation of Sandwich-Cultured Human Hepatocytes Using 17 Drugs

Organic Anion Transporter 2 Mediates Hepatic Uptake of Tolbutamide, a CYP2C9 Probe Drug

Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro–In Vivo Scaling of Hepatic Uptake Clearance

Use of cryopreserved human hepatocytes in sandwich culture to measure hepatobiliary transport

Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design

Characterization of Organic Anion Transporting Polypeptide (OATP) Expression and Its Functional Contribution to the Uptake of Substrates in Human Hepatocytes

Quantitative assessment of the contribution of sodium-dependent taurocholate co-transporting polypeptide (NTCP) to the hepatic uptake of rosuvastatin, pitavastatin and fluvastatin

Leveraging of Rifampicin-Dosed Cynomolgus Monkeys to Identify Bile Acid 3-O-Sulfate Conjugates as Potential Novel Biomarkers for Organic Anion-Transporting Polypeptides

Reliable Rate Measurements for Active and Passive Hepatic Uptake Using Plated Human Hepatocytes

In Vitro–In Vivo Extrapolation of OATP1B-Mediated Drug–Drug Interactions in Cynomolgus Monkey

Culture period-dependent changes in the uptake of transporter substrates in sandwich-cultured rat and human hepatocytes

In vitro evaluation of hepatic transporter-mediated clinical drug-drug interactions: hepatocyte model optimization and retrospective investigation

Quantitative prediction of repaglinide-rifampicin complex drug interactions using dynamic and static mechanistic models: delineating differential CYP3A4 induction and OATP1B1 inhibition potential of rifampicin

Quantitative Expression Profile of Hepatobiliary Transporters in Sandwich Cultured Rat and Human Hepatocytes

Characterization of digoxin uptake in sandwich-cultured human hepatocytes

OATP1B-mediated hepatic uptake of low-molecular weight acid compounds: assessment of HIF prolyl-hydroxylase inhibitors (DUSTATS)

Role of Hepatic Transporters in the Disposition and Hepatotoxicity of a HER2 Tyrosine Kinase Inhibitor CP-724,714

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