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Novel BET protein proteolysis-targeting chimera exerts superior lethal activity than bromodomain inhibitor (BETi) against post-myeloproliferative neoplasm secondary (s) AML cells

Leukemia, 2017-09, Vol.31 (9), p.1951-1961

2017

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BET protein proteolysis targeting chimera (PROTAC) exerts potent lethal activity against mantle cell lymphoma cells

Leukemia, 2018-02, Vol.32 (2), p.343-352

2018

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BET protein bromodomain inhibitor-based combinations are highly active against post-myeloproliferative neoplasm secondary AML cells

Leukemia, 2017-03, Vol.31 (3), p.678-687

2017

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The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy

Leukemia, 2001-10, Vol.15 (10), p.1537-1543

2001

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Microtubule-targeted anticancer agents and apoptosis

Oncogene, 2003-12, Vol.22 (56), p.9075-9086

Bhalla, Kapil N

2003

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Phase Ia/II, two-arm, open-label, dose-escalation study of oral panobinostat administered via two dosing schedules in patients with advanced hematologic malignancies

Leukemia, 2013-08, Vol.27 (8), p.1628-1636

2013

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Pre-clinical efficacy of combined therapy with novel β-catenin antagonist BC2059 and histone deacetylase inhibitor against AML cells

Leukemia, 2015-06, Vol.29 (6), p.1267-1278

2015

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The role of Apaf-1, caspase-9, and bid proteins in etoposide- or paclitaxel-induced mitochondrial events during apoptosis

Cancer research (Chicago, Ill.), 2000-03, Vol.60 (6), p.1645-1653

2000

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Co-treatment with As2O3 enhances selective cytotoxic effects of STI-571 against Bcr-Abl-positive acute leukemia cells

Leukemia, 2001-05, Vol.15 (5), p.772-778

2001

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HEXIM1 induction is mechanistically involved in mediating anti-AML activity of BET protein bromodomain antagonist

Leukemia, 2016-02, Vol.30 (2), p.504-508

2016

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HDAC1,2 inhibition and doxorubicin impair Mre11-dependent DNA repair and DISC to override BCR-ABL1-driven DSB repair in Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia

Leukemia, 2018-01, Vol.32 (1), p.49-60

2018

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Taxol metabolism and disposition in cancer patients

Drug metabolism and disposition, 1995-04, Vol.23 (4), p.506

1995

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Interleukin-3 protects Bcr-Abl-transformed hematopoietic progenitor cells from apoptosis induced by Bcr-Abl tyrosine kinase inhibitors

Leukemia, 2002-09, Vol.16 (9), p.1589-1595

2002

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CGP57148B (STI-571) induces differentiation and apoptosis and sensitizes Bcr-Abl–positive human leukemia cells to apoptosis due to antileukemic drugs

Blood, 2000-09, Vol.96 (6), p.2246-2253

2000

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Loop domain is necessary for Taxol-induced mobility shift and phosphorylation of Bcl-2 as well as for inhibiting Taxol-induced cytosolic accumulation of cytochrome c and apoptosis

Cancer research (Chicago, Ill.), 1998-08, Vol.58 (15), p.3202-3208

1998

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Overexpression of Apaf-1 promotes apoptosis of untreated and paclitaxel- or etoposide-treated HL-60 cells

Cancer research (Chicago, Ill.), 1998-10, Vol.58 (20), p.4561-4566

1998

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Prediction of outcomes in patients with Ph+ chronic myeloid leukemia in chronic phase treated with nilotinib after imatinib resistance/intolerance

Leukemia, 2013-04, Vol.27 (4), p.907-913

2013

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Activation of Phosphatidylinositol 3-Kinase/Akt Pathway by Androgen through Interaction of p85α, Androgen Receptor, and Src

The Journal of biological chemistry, 2003-10, Vol.278 (44), p.42992-43000

2003

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Dose reduction to normal tissues as compared to the gross tumor by using intensity modulated radiotherapy in thoracic malignancies

Radiation oncology (London, England), 2006-08, Vol.1 (1), p.31-31, Article 31

2006

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Alpha/Beta Interferons Potentiate Virus-Induced Apoptosis through Activation of the FADD/Caspase-8 Death Signaling Pathway

Journal of Virology, 2000-02, Vol.74 (3), p.1513-1523

2000

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Pretreatment with paclitaxel enhances Apo-2 ligand/tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of prostate cancer cells by inducing death receptors 4 and 5 protein levels

Cancer research (Chicago, Ill.), 2001-01, Vol.61 (2), p.759-763

2001

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Arsenic induces apoptosis of multidrug-resistant human myeloid leukemia cells that express Bcr-Abl or overexpress MDR, MRP, Bcl-2, or Bcl-x(L)

Blood, 2000-02, Vol.95 (3), p.1014

2000

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Epothilone B analogue (BMS-247550)-mediated cytotoxicity through induction of Bax conformational change in human breast cancer cells

Cancer research (Chicago, Ill.), 2002-01, Vol.62 (2), p.466-471

2002

Volltextzugriff (PDF)

Magnetic resonance imaging in carcinoma cervix- Does it have a prognostic relevance

Journal of cancer research and therapeutics, 2005-04, Vol.1 (2), p.103-107

Sethi TejinderKataria, Bhalla NK, Jena AN, Rawat S, Oberoi R

2005

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Epigenetic and Chromatin Modifiers As Targeted Therapy of Hematologic Malignancies

Journal of clinical oncology, 2005-06, Vol.23 (17), p.3971-3993

BHALLA, Kapil N

2005

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Novel BET protein proteolysis-targeting chimera exerts superior lethal activity than bromodomain inhibitor (BETi) against post-myeloproliferative neoplasm secondary (s) AML cells

BET protein proteolysis targeting chimera (PROTAC) exerts potent lethal activity against mantle cell lymphoma cells

BET protein bromodomain inhibitor-based combinations are highly active against post-myeloproliferative neoplasm secondary AML cells

The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy

Microtubule-targeted anticancer agents and apoptosis

Phase Ia/II, two-arm, open-label, dose-escalation study of oral panobinostat administered via two dosing schedules in patients with advanced hematologic malignancies

Pre-clinical efficacy of combined therapy with novel β-catenin antagonist BC2059 and histone deacetylase inhibitor against AML cells

The role of Apaf-1, caspase-9, and bid proteins in etoposide- or paclitaxel-induced mitochondrial events during apoptosis

Co-treatment with As2O3 enhances selective cytotoxic effects of STI-571 against Bcr-Abl-positive acute leukemia cells

HEXIM1 induction is mechanistically involved in mediating anti-AML activity of BET protein bromodomain antagonist

HDAC1,2 inhibition and doxorubicin impair Mre11-dependent DNA repair and DISC to override BCR-ABL1-driven DSB repair in Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia

Taxol metabolism and disposition in cancer patients

Interleukin-3 protects Bcr-Abl-transformed hematopoietic progenitor cells from apoptosis induced by Bcr-Abl tyrosine kinase inhibitors

CGP57148B (STI-571) induces differentiation and apoptosis and sensitizes Bcr-Abl–positive human leukemia cells to apoptosis due to antileukemic drugs

Loop domain is necessary for Taxol-induced mobility shift and phosphorylation of Bcl-2 as well as for inhibiting Taxol-induced cytosolic accumulation of cytochrome c and apoptosis

Overexpression of Apaf-1 promotes apoptosis of untreated and paclitaxel- or etoposide-treated HL-60 cells

Prediction of outcomes in patients with Ph+ chronic myeloid leukemia in chronic phase treated with nilotinib after imatinib resistance/intolerance

Activation of Phosphatidylinositol 3-Kinase/Akt Pathway by Androgen through Interaction of p85α, Androgen Receptor, and Src

Dose reduction to normal tissues as compared to the gross tumor by using intensity modulated radiotherapy in thoracic malignancies

Alpha/Beta Interferons Potentiate Virus-Induced Apoptosis through Activation of the FADD/Caspase-8 Death Signaling Pathway

Pretreatment with paclitaxel enhances Apo-2 ligand/tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of prostate cancer cells by inducing death receptors 4 and 5 protein levels

Arsenic induces apoptosis of multidrug-resistant human myeloid leukemia cells that express Bcr-Abl or overexpress MDR, MRP, Bcl-2, or Bcl-x(L)

Epothilone B analogue (BMS-247550)-mediated cytotoxicity through induction of Bax conformational change in human breast cancer cells

Magnetic resonance imaging in carcinoma cervix- Does it have a prognostic relevance

Epigenetic and Chromatin Modifiers As Targeted Therapy of Hematologic Malignancies

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