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Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach

ACS medicinal chemistry letters, 2016-08, Vol.7 (8), p.735-740

2016

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Optimization of a Fragment-Based Screening Hit toward Potent DOT1L Inhibitors Interacting in an Induced Binding Pocket

ACS medicinal chemistry letters, 2016-08, Vol.7 (8), p.730-734

2016

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Discovery of Potent, Selective, and Structurally Novel Dot1L Inhibitors by a Fragment Linking Approach

ACS medicinal chemistry letters, 2017-03, Vol.8 (3), p.338-343

2017

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A Mutation Hot Spot for Nonspecific X-Linked Mental Retardation in the MECP2 Gene Causes the PPM-X Syndrome

American journal of human genetics, 2002-04, Vol.70 (4), p.1034-1037

2002

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Structure of the MRAS-SHOC2-PP1C phosphatase complex

Nature (London), 2022-09, Vol.609 (7926), p.416-423

2022

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Mediator Subunit MED28 (Magicin) Is a Repressor of Smooth Muscle Cell Differentiation

The Journal of biological chemistry, 2007-11, Vol.282 (44), p.32152-32157

2007

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New Potent DOT1L Inhibitors for in Vivo Evaluation in Mouse

ACS medicinal chemistry letters, 2019-12, Vol.10 (12), p.1655-1660

2019

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Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C

Cancer discovery, 2022-06, Vol.12 (6), p.1500-1517

2022

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A comparative study of fragment screening methods on the p38α kinase: new methods, new insights

Journal of computer-aided molecular design, 2011-07, Vol.25 (7), p.677-687

2011

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FARP2, HDLBP and PASK are downregulated in a patient with autism and 2q37.3 deletion syndrome

American journal of medical genetics. Part A, 2009-05, Vol.149A (5), p.952-959

2009

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Mutation analysis of the coding sequence of the MECP2 gene in infantile autism

Human genetics, 2002-10, Vol.111 (4-5), p.305-309

2002

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Magicin associates with the Src-family kinases and is phosphorylated upon CD3 stimulation

Biochemical and biophysical research communications, 2006-09, Vol.348 (3), p.826-831

2006

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Abstract 1770: A new DOT1L inhibitor with in vivo activity in mouse models of MLL-translocated leukemia

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.1770-1770

2020

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Association studies of the HOPA dodecamer duplication variant in different subtypes of autism

American journal of medical genetics, 2002-01, Vol.114 (1), p.110-115

2002

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Mutation analysis of the coding sequence of the MECP2 gene in infantile autism

Human genetics, 2003-04, Vol.112 (4), p.437-437

2003

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Abstract 4026: JDQ443, a covalent inhibitor of KRASG12C with a novel binding mode, shows broad antitumor activity in KRASG12C preclinical models as a single agent and in combination with inhibitors of SHP2, MEK or CDK4/6

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.4026-4026

2022

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A comparative study of fragment screening methods on the p38[alpha] kinase: new methods, new insights

Journal of computer-aided molecular design, 2011-07, Vol.25 (7), p.677

2011

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Mutation screening and association analysis of six candidate genes for autism on chromosome 7q

European journal of human genetics : EJHG, 2005-02, Vol.13 (2), p.198-207

2005

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Magicin (MED28), a Potential Adaptor Protein

The FASEB journal, 2006-03, Vol.20 (4), p.A103-A103

2006

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Understanding the role of the merlin interacting protein magicin as part of the mammalian Mediator complex

The FASEB journal, 2006-03, Vol.20 (4), p.A79-A79

2006

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Construction of a physical map of an autism susceptibility region in 7q32.3-q33

Gene, 2001-07, Vol.272 (1-2), p.85-91

2001

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Should RAAS blockade therapy be continued in patients with advanced renal disease?

The Journal of family practice, 2023-04, Vol.72 (3), p.144-145

2023

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Q/Should RAAS blockade therapy be continued in patients with advanced renal disease?

The Journal of family practice, 2023-04, Vol.72 (3), p.144

2023

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Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach

Optimization of a Fragment-Based Screening Hit toward Potent DOT1L Inhibitors Interacting in an Induced Binding Pocket

Discovery of Potent, Selective, and Structurally Novel Dot1L Inhibitors by a Fragment Linking Approach

A Mutation Hot Spot for Nonspecific X-Linked Mental Retardation in the MECP2 Gene Causes the PPM-X Syndrome

JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRASG12C for the Treatment of Solid Tumors

Structure of the MRAS-SHOC2-PP1C phosphatase complex

Mediator Subunit MED28 (Magicin) Is a Repressor of Smooth Muscle Cell Differentiation

JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRAS G12C for the Treatment of Solid Tumors

New Potent DOT1L Inhibitors for in Vivo Evaluation in Mouse

Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C

A comparative study of fragment screening methods on the p38α kinase: new methods, new insights

FARP2, HDLBP and PASK are downregulated in a patient with autism and 2q37.3 deletion syndrome

Mutation analysis of the coding sequence of the MECP2 gene in infantile autism

Magicin associates with the Src-family kinases and is phosphorylated upon CD3 stimulation

Abstract 1770: A new DOT1L inhibitor with in vivo activity in mouse models of MLL-translocated leukemia

Association studies of the HOPA dodecamer duplication variant in different subtypes of autism

Mutation analysis of the coding sequence of the MECP2 gene in infantile autism

Abstract 4026: JDQ443, a covalent inhibitor of KRASG12C with a novel binding mode, shows broad antitumor activity in KRASG12C preclinical models as a single agent and in combination with inhibitors of SHP2, MEK or CDK4/6

A comparative study of fragment screening methods on the p38[alpha] kinase: new methods, new insights

Mutation screening and association analysis of six candidate genes for autism on chromosome 7q

Magicin (MED28), a Potential Adaptor Protein

Understanding the role of the merlin interacting protein magicin as part of the mammalian Mediator complex

Construction of a physical map of an autism susceptibility region in 7q32.3-q33

Should RAAS blockade therapy be continued in patients with advanced renal disease?

Q/Should RAAS blockade therapy be continued in patients with advanced renal disease?

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