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Matching the power of high throughput screening to the chemical diversity of natural products

Natural product reports, 2013-01, Vol.30 (10), p.1284-1298

2013

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Anatolicin, a Highly Potent and Selective Cytotoxic Sesquiterpene Coumarin from the Root Extract of Heptaptera anatolica

Molecules (Basel, Switzerland), 2019-03, Vol.24 (6), p.1153

2019

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Englerin A, a Selective Inhibitor of Renal Cancer Cell Growth, from Phyllanthus engleri

Organic letters, 2009-01, Vol.11 (1), p.57-60

2009

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Neopapillarine, an Unusual Coumarino-Alkaloid from the Root Extract of Neocryptodiscus papillaris with Cytotoxic Activity on Renal Cancer Cells

Molecules (Basel, Switzerland), 2020-07, Vol.25 (13), p.3040

2020

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Natural Products as a Foundation for Drug Discovery

Current Protocols in Pharmacology, 2009-09, Vol.46 (1), p.9.11.1-9.11.21

Beutler, John A.

2009

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Novel Cytotoxic Sesquiterpene Coumarin Ethers and Sulfur-Containing Compounds from the Roots of Ferula turcica

Molecules (Basel, Switzerland), 2023-07, Vol.28 (15), p.5733

2023

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Neopetrothiazide: An Intriguing Pentacyclic Thiazide Alkaloid from the Sponge Neopetrosia sp

Organic letters, 2021-05, Vol.23 (9), p.3278-3281

2021

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Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics

Cancer research (Chicago, Ill.), 2007-10, Vol.67 (19), p.9472-9481

2007

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Natural Products as a Foundation for Drug Discovery

Current Protocols in Pharmacology, 2019-09, Vol.86 (1), p.e67-n/a

Beutler, John A.

2019

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Englerin A Stimulates PKCθ to Inhibit Insulin Signaling and to Simultaneously Activate HSF1: Pharmacologically Induced Synthetic Lethality

Cancer cell, 2013-02, Vol.23 (2), p.228-237

2013

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Cytotoxic Triterpenes from Salacia crassifolia and Metabolite Profiling of Celastraceae Species

Molecules (Basel, Switzerland), 2018-06, Vol.23 (6), p.1494

2018

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Enantioselective Synthesis of (+)-Chamaecypanone C: A Novel Microtubule Inhibitor

Angewandte Chemie (International ed.), 2009-01, Vol.48 (8), p.1494-1497

2009

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Isobutylhydroxyamides from the Pericarp of Nepalese Zanthoxylum armatum Inhibit NF1-Defective Tumor Cell Line Growth

Journal of natural products (Washington, D.C.), 2013-01, Vol.76 (1), p.59-63

2013

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Sensitivity of the C-Terminal Nuclease Domain of Kaposi's Sarcoma-Associated Herpesvirus ORF29 to Two Classes of Active-Site Ligands

Antimicrobial agents and chemotherapy, 2018-10, Vol.62 (10)

2018

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Inhibition of Nitric Oxide Production in BV2 Microglial Cells by Triterpenes from Tetrapanax papyriferus

Molecules (Basel, Switzerland), 2016-04, Vol.21 (4), p.459-459

2016

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Synthesis and Biological Evaluation of ABCD Ring Fragments of the Kibdelones

Angewandte Chemie (International ed.), 2011-03, Vol.50 (11), p.2511-2515

International ed. in English, 2011

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Effects of Cinnamoyloxy-mammeisin from Geopropolis on Osteoclast Differentiation and Porphyromonas gingivalis-Induced Periodontitis

Journal of natural products (Washington, D.C.), 2017-06, Vol.80 (6), p.1893-1899

2017

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Scaffold hopping and optimisation of 3',4'-dihydroxyphenyl- containing thienopyrimidinones: synthesis of quinazolinone derivatives as novel allosteric inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H

Journal of enzyme inhibition and medicinal chemistry, 2020-01, Vol.35 (1), p.1953-1963

2020

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Identification of CB1/CB2 Ligands from Zanthoxylum bungeanum

Journal of natural products (Washington, D.C.), 2013-11, Vol.76 (11), p.2060-2064

2013

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Growth Inhibition of Human Colon Carcinoma Cells by Sesquiterpenoids and Tetralones of Zygogynum calothyrsum

Journal of natural products (Washington, D.C.), 2013-04, Vol.76 (4), p.710-714

2013

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A Convergent Total Synthesis of the Potent Cephalostatin/Ritterazine Hybrid -25-epi Ritterostatin GN1N

Journal of organic chemistry, 2013-09, Vol.78 (18), p.9085-9092

2013

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Preparative Purification of Anti-Proliferative Diarylheptanoids from Betula platyphylla by High-Speed Counter-Current Chromatography

Molecules (Basel, Switzerland), 2016-05, Vol.21 (6), p.700-700

2016

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A Molecular Networking Strategy: High-Throughput Screening and Chemical Analysis of Brazilian Cerrado Plant Extracts against Cancer Cells

Cells (Basel, Switzerland), 2021-03, Vol.10 (3), p.691

2021

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Structure-Activity Analysis of Vinylogous Urea Inhibitors of Human Immunodeficiency Virus-Encoded Ribonuclease H

Antimicrobial Agents and Chemotherapy, 2010-09, Vol.54 (9), p.3913-3921

2010

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Synthesis of a 35-Member Stereoisomer Library of Bistramide A: Evaluation of Effects on actin State, Cell Cycle and Tumor Cell Growth

Journal of organic chemistry, 2009-03, Vol.74 (5), p.1897-1916

2009

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Matching the power of high throughput screening to the chemical diversity of natural products

Anatolicin, a Highly Potent and Selective Cytotoxic Sesquiterpene Coumarin from the Root Extract of Heptaptera anatolica

Englerin A, a Selective Inhibitor of Renal Cancer Cell Growth, from Phyllanthus engleri

Neopapillarine, an Unusual Coumarino-Alkaloid from the Root Extract of Neocryptodiscus papillaris with Cytotoxic Activity on Renal Cancer Cells

Natural Products as a Foundation for Drug Discovery

Novel Cytotoxic Sesquiterpene Coumarin Ethers and Sulfur-Containing Compounds from the Roots of Ferula turcica

Neopetrothiazide: An Intriguing Pentacyclic Thiazide Alkaloid from the Sponge Neopetrosia sp

Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics

Natural Products as a Foundation for Drug Discovery

Englerin A Stimulates PKCθ to Inhibit Insulin Signaling and to Simultaneously Activate HSF1: Pharmacologically Induced Synthetic Lethality

Cytotoxic Triterpenes from Salacia crassifolia and Metabolite Profiling of Celastraceae Species

Enantioselective Synthesis of (+)-Chamaecypanone C: A Novel Microtubule Inhibitor

Isobutylhydroxyamides from the Pericarp of Nepalese Zanthoxylum armatum Inhibit NF1-Defective Tumor Cell Line Growth

Sensitivity of the C-Terminal Nuclease Domain of Kaposi's Sarcoma-Associated Herpesvirus ORF29 to Two Classes of Active-Site Ligands

Inhibition of Nitric Oxide Production in BV2 Microglial Cells by Triterpenes from Tetrapanax papyriferus

Synthesis and Biological Evaluation of ABCD Ring Fragments of the Kibdelones

Effects of Cinnamoyloxy-mammeisin from Geopropolis on Osteoclast Differentiation and Porphyromonas gingivalis-Induced Periodontitis

Scaffold hopping and optimisation of 3',4'-dihydroxyphenyl- containing thienopyrimidinones: synthesis of quinazolinone derivatives as novel allosteric inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H

Identification of CB1/CB2 Ligands from Zanthoxylum bungeanum

Growth Inhibition of Human Colon Carcinoma Cells by Sesquiterpenoids and Tetralones of Zygogynum calothyrsum

A Convergent Total Synthesis of the Potent Cephalostatin/Ritterazine Hybrid -25-epi Ritterostatin GN1N

Preparative Purification of Anti-Proliferative Diarylheptanoids from Betula platyphylla by High-Speed Counter-Current Chromatography

A Molecular Networking Strategy: High-Throughput Screening and Chemical Analysis of Brazilian Cerrado Plant Extracts against Cancer Cells

Structure-Activity Analysis of Vinylogous Urea Inhibitors of Human Immunodeficiency Virus-Encoded Ribonuclease H

Synthesis of a 35-Member Stereoisomer Library of Bistramide A: Evaluation of Effects on actin State, Cell Cycle and Tumor Cell Growth

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