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Cell engineering with microfluidic squeezing preserves functionality of primary immune cells in vivo

Proceedings of the National Academy of Sciences - PNAS, 2018-11, Vol.115 (46), p.E10907-E10914

2018

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SOS-NMR: A Saturation Transfer NMR-Based Method for Determining the Structures of Protein−Ligand Complexes

Journal of the American Chemical Society, 2004-03, Vol.126 (8), p.2390-2398

2004

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Synthesis and Structure−Activity Relationships of N-{3-[2-(4-Alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy Derivatives as Selective Acetyl-CoA Carboxylase 2 Inhibitors

Journal of medicinal chemistry, 2006-06, Vol.49 (13), p.3770-3773

2006

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An ultraefficient affinity-based high-throughout screening process: application to bacterial cell wall biosynthesis enzyme MurF

Journal of biomolecular screening, 2006-10, Vol.11 (7), p.743-754

2006

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Phenoxy thiazole derivatives as potent and selective acetyl-CoA carboxylase 2 inhibitors: Modulation of isozyme selectivity by incorporation of phenyl ring substituents

Bioorganic & medicinal chemistry letters, 2007-04, Vol.17 (7), p.1961-1965

2007

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Mechanism of Action of a Novel Series of Naphthyridine-Type Ribosome Inhibitors: Enhancement of tRNA Footprinting at the Decoding Site of 16S rRNA

Antimicrobial Agents and Chemotherapy, 2005-05, Vol.49 (5), p.1890-1897

2005

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Synthesis and SAR evaluation of oxadiazolopyrazines as selective Haemophilus influenzae antibacterial agents

Bioorganic & medicinal chemistry letters, 2003-10, Vol.13 (19), p.3133-3136

2003

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Novel Approach to Mapping of Resistance Mutations in Whole Genomes by Using Restriction Enzyme Modulation of Transformation Efficiency

Antimicrobial Agents and Chemotherapy, 2005-07, Vol.49 (7), p.2767-2777

2005

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Structural and Functional Characterization of Potent Antithrombotic Oligonucleotides Possessing Both Quadruplex and Duplex Motifs

Biochemistry (Easton), 1995-04, Vol.34 (13), p.4478-4492

1995

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Structure of MurF from Streptococcus pneumoniae co‐crystallized with a small molecule inhibitor exhibits interdomain closure

Protein science, 2005-12, Vol.14 (12), p.3039-3047

2005

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N-{3-[2-(4-Alkoxyphenoxy)thiazol-5-yl]-1-methylprop-2-ynyl}carboxy Derivatives as Acetyl-CoA Carboxylase InhibitorsImprovement of Cardiovascular and Neurological Liabilities via Structural Modifications

Journal of medicinal chemistry, 2007-03, Vol.50 (5), p.1078-1082

2007

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The synthesis and structure–activity relationship studies of selective acetyl-CoA carboxylase inhibitors containing 4-(thiazol-5-yl)but-3-yn-2-amino motif: Polar region modifications

Bioorganic & medicinal chemistry letters, 2007-03, Vol.17 (6), p.1803-1807

2007

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Novel Antibacterial Class: A Series of Tetracyclic Derivatives

Journal of medicinal chemistry, 2006-08, Vol.49 (16), p.4842-4856

2006

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Structure–activity relationships for a novel series of thiazolyl phenyl ether derivatives exhibiting potent and selective acetyl-CoA carboxylase 2 inhibitory activity

Bioorganic & medicinal chemistry letters, 2006-12, Vol.16 (23), p.6078-6081

2006

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Structure–activity relationships of novel potent MurF inhibitors

Bioorganic & medicinal chemistry letters, 2004-01, Vol.14 (1), p.267-270

2004

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Structure-based Optimization of MurF Inhibitors

Chemical biology & drug design, 2006-01, Vol.67 (1), p.58-65

2006

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Novel Antibacterial Class

Antimicrobial Agents and Chemotherapy, 2003-12, Vol.47 (12), p.3831-3839

2003

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Synthesis and Structure−Activity Relationships of N-{3-[2-(4-Alkoxyphenoxy)thiazol-5-yl]-1-methylprop-2-ynyl}carboxy Derivatives as Selective Acetyl-CoA Carboxylase 2 Inhibitors

Journal of medicinal chemistry, 2006-08, Vol.49 (16), p.5028-5028

2006

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From Bacterial Genomes to Novel Antibacterial Agents: Discovery, Characterization, and Antibacterial Activity of Compounds that Bind to HI0065 (YjeE) from Haemophilus influenzae

Chemical biology & drug design, 2007-06, Vol.69 (6), p.395-404

2007

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Synthesis and antibacterial activity of 5-methoxy- and 5-hydroxy-6-fluoro-1,8-naphthyridone-3-carboxylic acid derivatives

Bioorganic & medicinal chemistry letters, 2005-06, Vol.15 (11), p.2716-2719

2005

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Novel inhibitors of bacterial protein synthesis: structure–activity relationships for 1,8-naphthyridine derivatives incorporating position 3 and 4 variants

Bioorganic & medicinal chemistry letters, 2004-06, Vol.14 (12), p.3299-3302

2004

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A strategy for high-throughput assay development using leads derived from nuclear magnetic resonance-based screening

Journal of biomolecular screening, 2002-10, Vol.7 (5), p.429-432

2002

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A strategy for discovery of novel broad-spectrum antibacterials using a high-throughput Streptococcus pneumoniae transcription/translation screen

Journal of biomolecular screening, 2004-02, Vol.9 (1), p.3-11

2004

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In vitro evolution of intrinsically bent DNA

Journal of molecular biology, 1992-12, Vol.228 (3), p.803-812

1992

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Antibacterial drug discovery in the post-genomics era

Current drug targets. Infectious disorders, 2002-06, Vol.2 (2), p.109

2002

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Cell engineering with microfluidic squeezing preserves functionality of primary immune cells in vivo

SOS-NMR: A Saturation Transfer NMR-Based Method for Determining the Structures of Protein−Ligand Complexes

Synthesis and Structure−Activity Relationships of N-{3-[2-(4-Alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy Derivatives as Selective Acetyl-CoA Carboxylase 2 Inhibitors

An ultraefficient affinity-based high-throughout screening process: application to bacterial cell wall biosynthesis enzyme MurF

Phenoxy thiazole derivatives as potent and selective acetyl-CoA carboxylase 2 inhibitors: Modulation of isozyme selectivity by incorporation of phenyl ring substituents

Mechanism of Action of a Novel Series of Naphthyridine-Type Ribosome Inhibitors: Enhancement of tRNA Footprinting at the Decoding Site of 16S rRNA

Synthesis and SAR evaluation of oxadiazolopyrazines as selective Haemophilus influenzae antibacterial agents

Novel Approach to Mapping of Resistance Mutations in Whole Genomes by Using Restriction Enzyme Modulation of Transformation Efficiency

Structural and Functional Characterization of Potent Antithrombotic Oligonucleotides Possessing Both Quadruplex and Duplex Motifs

Structure of MurF from Streptococcus pneumoniae co‐crystallized with a small molecule inhibitor exhibits interdomain closure

N-{3-[2-(4-Alkoxyphenoxy)thiazol-5-yl]-1-methylprop-2-ynyl}carboxy Derivatives as Acetyl-CoA Carboxylase InhibitorsImprovement of Cardiovascular and Neurological Liabilities via Structural Modifications

The synthesis and structure–activity relationship studies of selective acetyl-CoA carboxylase inhibitors containing 4-(thiazol-5-yl)but-3-yn-2-amino motif: Polar region modifications

Novel Antibacterial Class: A Series of Tetracyclic Derivatives

Structure–activity relationships for a novel series of thiazolyl phenyl ether derivatives exhibiting potent and selective acetyl-CoA carboxylase 2 inhibitory activity

Structure–activity relationships of novel potent MurF inhibitors

Structure-based Optimization of MurF Inhibitors

Novel Antibacterial Class

Synthesis and Structure−Activity Relationships of N-{3-[2-(4-Alkoxyphenoxy)thiazol-5-yl]-1-methylprop-2-ynyl}carboxy Derivatives as Selective Acetyl-CoA Carboxylase 2 Inhibitors

From Bacterial Genomes to Novel Antibacterial Agents: Discovery, Characterization, and Antibacterial Activity of Compounds that Bind to HI0065 (YjeE) from Haemophilus influenzae

Synthesis and antibacterial activity of 5-methoxy- and 5-hydroxy-6-fluoro-1,8-naphthyridone-3-carboxylic acid derivatives

Novel inhibitors of bacterial protein synthesis: structure–activity relationships for 1,8-naphthyridine derivatives incorporating position 3 and 4 variants

A strategy for high-throughput assay development using leads derived from nuclear magnetic resonance-based screening

A strategy for discovery of novel broad-spectrum antibacterials using a high-throughput Streptococcus pneumoniae transcription/translation screen

In vitro evolution of intrinsically bent DNA

Antibacterial drug discovery in the post-genomics era

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