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Translational strategy using multiple nuclear imaging biomarkers to evaluate target engagement and early therapeutic efficacy of SAR439859, a novel selective estrogen receptor degrader

EJNMMI research, 2020-06, Vol.10 (1), p.70-70, Article 70

2020

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SAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (20), p.5855-5865

2014

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Assessing Tumor Mechanics by MR Elastography at Different Strain Levels

Journal of magnetic resonance imaging, 2019-12, Vol.50 (6), p.1982-1989

2019

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Synthesis, radiosynthesis and in vivo evaluation of 5-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-1,3-dihydrobenzoimidazol-2-[11C]one, as a potent NR1A/2B subtype selective NMDA PET radiotracer

Bioorganic & medicinal chemistry, 2003-12, Vol.11 (24), p.5401-5408

2003

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Abstract 739: Preclinical and clinical activity of SAR439859, Amcenestrant, a next generation SERD

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.739-739

2021

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Assessing Tumor Mechanics by MR Elastography at Different Strain Levels

Journal of magnetic resonance imaging, 2019-12, Vol.50 (6), p.1982-1989

2019

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Tumor Solid Stress: Assessment with MR Elastography under Compression of Patient-Derived Hepatocellular Carcinomas and Cholangiocarcinomas Xenografted in Mice

Cancers, 2021-04, Vol.13 (8), p.1891

2021

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In vivo Quantification of Localized Neuronal Activation and Inhibition in the Rat Brain Using a Dedicated High Temporal-Resolution β+-Sensitive Microprobe

Proceedings of the National Academy of Sciences - PNAS, 2002-08, Vol.99 (16), p.10807-10812

2002

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Radiosynthesis of ( E)- N-(2-[ 11C]methoxybenzyl)-3-phenyl-acrylamidine, a novel subnanomolar NR2B subtype-selective NMDA receptor antagonist

Applied radiation and isotopes, 2006-03, Vol.64 (3), p.348-354

2006

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Preclinical assessment of estrogen receptor suppression by SAR439859-a new SERD therapy-using 18F-fluoroestradiol positron emission tomography (FES-PET)

The Journal of nuclear medicine (1978), 2018-02, Vol.59 (2), p.360

2018

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Functional Recovery in a Primate Model of Parkinson's Disease following Motor Cortex Stimulation

Neuron (Cambridge, Mass.), 2004-12, Vol.44 (5), p.769-778

2004

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Abstract 5775: Identification of SAR439859, an orally bioavailable selective estrogen receptor degrader (SERD) that has strong anti-tumor activity in wild-type and mutant ER+ breast cancer models

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.5775-5775

2018

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3′-Deoxy-3′-[18F]Fluorothymidine Uptake Is Related to Thymidine Phosphorylase Expression in Various Experimental Tumor Models

Molecular imaging and biology, 2018-04, Vol.20 (2), p.194-199

2018

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Isoflurane strongly affects the diffusion of intracellular metabolites, as shown by H nuclear magnetic resonance spectroscopy of the monkey brain

Journal of cerebral blood flow and metabolism, 2007-03, Vol.27 (3), p.588-596

2007

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Arterial input function measurement without blood sampling using a beta-microprobe in rats

The Journal of nuclear medicine (1978), 2004-09, Vol.45 (9), p.1577-1582

2004

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Positron Emission Tomography Imaging Demonstrates Correlation between Behavioral Recovery and Correction of Dopamine Neurotransmission after Gene Therapy

The Journal of neuroscience, 2009-02, Vol.29 (5), p.1544-1553

2009

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Quantitative validation of voxel-wise statistical analyses of autoradiographic rat brain volumes: Application to unilateral visual stimulation

NeuroImage (Orlando, Fla.), 2008-04, Vol.40 (2), p.482-494

2008

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Abstract 714: Non-invasive monitoring of the antitumor activity of SAR650984 anti-CD38 antibody against disseminated human Daudi lymphoma using 18F-FDG micro Positron Emission Tomography

Cancer research (Chicago, Ill.), 2010-04, Vol.70 (8_Supplement), p.714-714

2010

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Abstract 4731: Cytotoxic versus cytostatic effects in tumor models by spiro-oxindole-based modulators of the MDM2-p53 interaction

Cancer research (Chicago, Ill.), 2012-04, Vol.72 (8_Supplement), p.4731-4731

2012

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Abstract 3258: Discovery and characterization of SAR260301, a novel PI3Kβ-selective inhibitor in clinical development for the treatment of PTEN-deficient tumors

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.3258-3258

2013

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Automated three-dimensional analysis of histological and autoradiographic rat brain sections: application to an activation study

Journal of cerebral blood flow and metabolism, 2007-10, Vol.27 (10), p.1742-1755

2007

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Glycolysis versus TCA cycle in the primate brain as measured by combining F-FDG PET and C-NMR

Journal of cerebral blood flow and metabolism, 2005-11, Vol.25 (11), p.1418-1423

2005

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Optimized diffusion-weighted spectroscopy for measuring brain glutamate apparent diffusion coefficient on a whole-body MR system

NMR in biomedicine, 2005-12, Vol.18 (8), p.527-533

2005

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Imaging in cell-based therapy for neurodegenerative diseases

European journal of nuclear medicine and molecular imaging, 2005-12, Vol.32 Suppl 2 (S02), p.S417-S434

2005

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Translational strategy using multiple nuclear imaging biomarkers to evaluate target engagement and early therapeutic efficacy of SAR439859, a novel selective estrogen receptor degrader

SAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression

SAR439859, a Novel Selective Estrogen Receptor Degrader (SERD), Demonstrates Effective and Broad Antitumor Activity in Wild-Type and Mutant ER-Positive Breast Cancer Models

Assessing Tumor Mechanics by MR Elastography at Different Strain Levels

Synthesis, radiosynthesis and in vivo evaluation of 5-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-1,3-dihydrobenzoimidazol-2-[11C]one, as a potent NR1A/2B subtype selective NMDA PET radiotracer

Abstract 739: Preclinical and clinical activity of SAR439859, Amcenestrant, a next generation SERD

Assessing Tumor Mechanics by MR Elastography at Different Strain Levels

Tumor Solid Stress: Assessment with MR Elastography under Compression of Patient-Derived Hepatocellular Carcinomas and Cholangiocarcinomas Xenografted in Mice

In vivo Quantification of Localized Neuronal Activation and Inhibition in the Rat Brain Using a Dedicated High Temporal-Resolution β+-Sensitive Microprobe

Radiosynthesis of ( E)- N-(2-[ 11C]methoxybenzyl)-3-phenyl-acrylamidine, a novel subnanomolar NR2B subtype-selective NMDA receptor antagonist

Preclinical assessment of estrogen receptor suppression by SAR439859-a new SERD therapy-using 18F-fluoroestradiol positron emission tomography (FES-PET)

Functional Recovery in a Primate Model of Parkinson's Disease following Motor Cortex Stimulation

Abstract 5775: Identification of SAR439859, an orally bioavailable selective estrogen receptor degrader (SERD) that has strong anti-tumor activity in wild-type and mutant ER+ breast cancer models

3′-Deoxy-3′-[18F]Fluorothymidine Uptake Is Related to Thymidine Phosphorylase Expression in Various Experimental Tumor Models

Isoflurane strongly affects the diffusion of intracellular metabolites, as shown by H nuclear magnetic resonance spectroscopy of the monkey brain

Arterial input function measurement without blood sampling using a beta-microprobe in rats

Positron Emission Tomography Imaging Demonstrates Correlation between Behavioral Recovery and Correction of Dopamine Neurotransmission after Gene Therapy

Quantitative validation of voxel-wise statistical analyses of autoradiographic rat brain volumes: Application to unilateral visual stimulation

Abstract 714: Non-invasive monitoring of the antitumor activity of SAR650984 anti-CD38 antibody against disseminated human Daudi lymphoma using 18F-FDG micro Positron Emission Tomography

Abstract 4731: Cytotoxic versus cytostatic effects in tumor models by spiro-oxindole-based modulators of the MDM2-p53 interaction

Abstract 3258: Discovery and characterization of SAR260301, a novel PI3Kβ-selective inhibitor in clinical development for the treatment of PTEN-deficient tumors

Automated three-dimensional analysis of histological and autoradiographic rat brain sections: application to an activation study

Glycolysis versus TCA cycle in the primate brain as measured by combining F-FDG PET and C-NMR

Optimized diffusion-weighted spectroscopy for measuring brain glutamate apparent diffusion coefficient on a whole-body MR system

Imaging in cell-based therapy for neurodegenerative diseases

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