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Targeting Krasg12c‐mutant cancer with a mutation‐specific inhibitor

Journal of internal medicine, 2020-08, Vol.288 (2), p.183-191

2020

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Oncogene-induced senescence underlies the mutual exclusive nature of oncogenic KRAS and BRAF

Oncogene, 2016-03, Vol.35 (10), p.1328-1333

2016

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Wild-type KRAS inhibits oncogenic KRAS-induced T-ALL in mice

Leukemia, 2015-05, Vol.29 (5), p.1032-1040

2015

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Targeting filamin B induces tumor growth and metastasis via enhanced activity of matrix metalloproteinase-9 and secretion of VEGF-A

Oncogenesis (New York, NY), 2014-09, Vol.3 (9), p.e119-e119

2014

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Inactivating GGTase-I reduces disease phenotypes in a mouse model of K-RAS-induced myeloproliferative disease

Leukemia, 2011-01, Vol.25 (1), p.186-189

2011

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The long noncoding RNA ADIPINT regulates human adipocyte metabolism via pyruvate carboxylase

Nature communications, 2022-05, Vol.13 (1), p.2958-2958, Article 2958

2022

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Targeting Kras g12c -mutant cancer with a mutation-specific inhibitor

Journal of internal medicine, 2020-08, Vol.288 (2), p.183-191

2020

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A MYC-controlled redox switch protects B lymphoma cells from EGR1-dependent apoptosis

Cell reports (Cambridge), 2023-08, Vol.42 (8), p.112961-112961, Article 112961

2023

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The MTH1 inhibitor TH588 is a microtubule-modulating agent that eliminates cancer cells by activating the mitotic surveillance pathway

Scientific reports, 2019-10, Vol.9 (1), p.14667, Article 14667

2019

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Targeting the phospholipase A2 receptor ameliorates premature aging phenotypes

Aging cell, 2018-12, Vol.17 (6), p.e12835-n/a

2018

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On the physiological importance of endoproteolysis of CAAX proteins: heart-specific RCE1 knockout mice develop a lethal cardiomyopathy

The Journal of biological chemistry, 2004-02, Vol.279 (6), p.4729-4736

2004

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Mitochondria-Targeted Antioxidants MitoQ and MitoTEMPO Do Not Influence BRAF-Driven Malignant Melanoma and KRAS-Driven Lung Cancer Progression in Mice

Antioxidants, 2021, Vol.10 (2), p.163

2021

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Blocking Protein Farnesyltransferase Improves Nuclear Blebbing in Mouse Fibroblasts with a Targeted Hutchinson-Gilford Progeria Syndrome Mutation

Proceedings of the National Academy of Sciences - PNAS, 2005-07, Vol.102 (29), p.10291-10296

2005

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BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis

Cell, 2019-07, Vol.178 (2), p.330-345.e22

2019

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Absence of the CAAX Endoprotease Rce1: Effects on Cell Growth and Transformation

Molecular and Cellular Biology, 2002-01, Vol.22 (1), p.171-181

2002

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Antioxidants can increase melanoma metastasis in mice

Science translational medicine, 2015-10, Vol.7 (308), p.308re8

2015

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Isoprenylcysteine Carboxyl Methyltransferase Deficiency in Mice

The Journal of biological chemistry, 2001-02, Vol.276 (8), p.5841-5845

2001

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Targeted Inactivation of the Isoprenylcysteine Carboxyl Methyltransferase Gene Causes Mislocalization of K-Ras in Mammalian Cells

The Journal of biological chemistry, 2000-06, Vol.275 (23), p.17605-17610

2000

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The JAK1/2 inhibitor ruxolitinib delays premature aging phenotypes

Aging cell, 2020-04, Vol.19 (4), p.e13122-n/a

2020

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Glutamine Links Obesity to Inflammation in Human White Adipose Tissue

Cell metabolism, 2020-02, Vol.31 (2), p.375-390.e11

2020

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Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions

Nature communications, 2019-09, Vol.10 (1), p.3975-13, Article 3975

2019

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Lack of RAC1 in macrophages protects against atherosclerosis

PloS one, 2020-09, Vol.15 (9), p.e0239284-e0239284

2020

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The C-terminal Polylysine Region and Methylation of K-Ras Are Critical for the Interaction between K-Ras and Microtubules

The Journal of biological chemistry, 2000-12, Vol.275 (52), p.41251-41257

2000

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Transient expression of an adenine base editor corrects the Hutchinson-Gilford progeria syndrome mutation and improves the skin phenotype in mice

Nature communications, 2022-06, Vol.13 (1), p.3068-3068, Article 3068

2022

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Biochemical Studies of Zmpste24-deficient Mice

The Journal of biological chemistry, 2001-08, Vol.276 (31), p.29051-29058

2001

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Targeting Krasg12c‐mutant cancer with a mutation‐specific inhibitor

Oncogene-induced senescence underlies the mutual exclusive nature of oncogenic KRAS and BRAF

Wild-type KRAS inhibits oncogenic KRAS-induced T-ALL in mice

Targeting filamin B induces tumor growth and metastasis via enhanced activity of matrix metalloproteinase-9 and secretion of VEGF-A

Inactivating GGTase-I reduces disease phenotypes in a mouse model of K-RAS-induced myeloproliferative disease

The long noncoding RNA ADIPINT regulates human adipocyte metabolism via pyruvate carboxylase

Targeting Kras g12c -mutant cancer with a mutation-specific inhibitor

A MYC-controlled redox switch protects B lymphoma cells from EGR1-dependent apoptosis

The MTH1 inhibitor TH588 is a microtubule-modulating agent that eliminates cancer cells by activating the mitotic surveillance pathway

Targeting the phospholipase A2 receptor ameliorates premature aging phenotypes

On the physiological importance of endoproteolysis of CAAX proteins: heart-specific RCE1 knockout mice develop a lethal cardiomyopathy

Mitochondria-Targeted Antioxidants MitoQ and MitoTEMPO Do Not Influence BRAF-Driven Malignant Melanoma and KRAS-Driven Lung Cancer Progression in Mice

Blocking Protein Farnesyltransferase Improves Nuclear Blebbing in Mouse Fibroblasts with a Targeted Hutchinson-Gilford Progeria Syndrome Mutation

BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis

Absence of the CAAX Endoprotease Rce1: Effects on Cell Growth and Transformation

Antioxidants can increase melanoma metastasis in mice

Isoprenylcysteine Carboxyl Methyltransferase Deficiency in Mice

Targeted Inactivation of the Isoprenylcysteine Carboxyl Methyltransferase Gene Causes Mislocalization of K-Ras in Mammalian Cells

The JAK1/2 inhibitor ruxolitinib delays premature aging phenotypes

Glutamine Links Obesity to Inflammation in Human White Adipose Tissue

Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions

Lack of RAC1 in macrophages protects against atherosclerosis

The C-terminal Polylysine Region and Methylation of K-Ras Are Critical for the Interaction between K-Ras and Microtubules

Transient expression of an adenine base editor corrects the Hutchinson-Gilford progeria syndrome mutation and improves the skin phenotype in mice

Biochemical Studies of Zmpste24-deficient Mice

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