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BTK gatekeeper residue variation combined with cysteine 481 substitution causes super-resistance to irreversible inhibitors acalabrutinib, ibrutinib and zanubrutinib

Leukemia, 2021-05, Vol.35 (5), p.1317-1329

2021

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Comparative Analysis of BTK Inhibitors and Mechanisms Underlying Adverse Effects

Frontiers in cell and developmental biology, 2021-03, Vol.9, p.630942-630942

2021

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Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain

Immunological reviews, 2009-03, Vol.228 (1), p.58-73

2009

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Ibrutinib Has Time‐dependent On‐ and Off‐target Effects on Plasma Biomarkers and Immune Cells in Chronic Lymphocytic Leukemia

HemaSphere, 2021-05, Vol.5 (5), p.e564-n/a

2021

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transcriptional regulator PLZF induces the development of CD44 high memory phenotype T cells

Proceedings of the National Academy of Sciences - PNAS, 2008-11, Vol.105 (46), p.17919-17924

2008

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Bruton's tyrosine kinase: cell biology, sequence conservation, mutation spectrum, siRNA modifications, and expression profiling

Immunological reviews, 2005-02, Vol.203 (1), p.200-215

2005

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Novel mouse model resistant to irreversible BTK inhibitors: a tool identifying new therapeutic targets and side effects

Blood advances, 2020-06, Vol.4 (11), p.2439-2450

2020

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Splice-Correction Strategies for Treatment of X-Linked Agammaglobulinemia

Current allergy and asthma reports, 2015-03, Vol.15 (3), p.510-510, Article 4

2015

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Transcriptional signatures of Itk-deficient CD3+, CD4+ and CD8+ T-cells

BMC genomics, 2009-05, Vol.10 (1), p.233-233

2009

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Regulation of Bruton Tyrosine Kinase by the Peptidylprolyl Isomerase Pin1

The Journal of biological chemistry, 2006-06, Vol.281 (26), p.18201-18207

2006

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Distinct gene expression signature in Btk-defective T1 B-cells

Biochemical and biophysical research communications, 2006-07, Vol.346 (2), p.461-469

2006

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BTKbase, Bruton Tyrosine Kinase Variant Database in X-Linked Agammaglobulinemia: Looking Back and Ahead

Human mutation, 2023, Vol.2023, p.1-12

2023

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Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model

The Journal of clinical investigation, 2014-09, Vol.124 (9), p.4067-4081

2014

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Functional Interaction of Caveolin-1 with Bruton's Tyrosine Kinase and Bmx

The Journal of biological chemistry, 2002-03, Vol.277 (11), p.9351-9357

2002

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Gene expression profile of B cells from Xid mice and Btk knockout mice

European Journal of Immunology, 2004-07, Vol.34 (7), p.1981-1991

2004

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In BTK, phosphorylated Y223 in the SH3 domain mirrors catalytic activity, but does not influence biological function

Blood advances, 2024-04, Vol.8 (8), p.1981-1990

2024

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Combination of Gatekeeper Mutations and Cysteine 481 Replacement Causes Super Resistance to the Irreversible BTK Inhibitors Ibrutinib, Acalabrutinib and Zanubrutinib

BLOOD, 2019-11, Vol.134 (Supplement_1), p.5759-5759

2019

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Ibrutinib induces rapid down‐regulation of inflammatory markers and altered transcription of chronic lymphocytic leukaemia‐related genes in blood and lymph nodes

British journal of haematology, 2018-10, Vol.183 (2), p.212-224

2018

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Agammaglobulinemia: causative mutations and their implications for novel therapies

Expert review of clinical immunology, 2013-12, Vol.9 (12), p.1205-1221

2013

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Defective Toll-like receptor 9-mediated cytokine production in B cells from Bruton's tyrosine kinase-deficient mice

Immunology, 2008-02, Vol.123 (2), p.239-249

2008

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695. Splice-Correction of X-Linked Agammaglobulinemia in a Human BAC-Transgenic Mouse Model Using Oligonucleotides

Molecular therapy, 2015-05, Vol.23, p.S277-S277

2015

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Very Early Effects of Ibrutinib on Tumor and Immune Cells in Blood and Lymph Nodes in Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) Patients

BLOOD, 2016-12, Vol.128 (22), p.3235-3235

2016

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Bruton's tyrosine kinase (Btk) : function, regulation, and transformation with special emphasis on the PH domain: Kinases & Phosphatases of the Immune System

Immunological reviews, 2009, Vol.228, p.58-73

2009

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Characterization of CD44-high memory phenotype T cells induced by enforced expression of the transcription factor PLZF (85.12)

JOURNAL OF IMMUNOLOGY, 2009, Vol.182 (1_Supplement), p.85-85.12

2009

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Pinning down Bruton’s tyrosine kinase (Btk) (B26)

JOURNAL OF IMMUNOLOGY, 2007, Vol.178 (1_Supplement), p.LB5-LB6

2007

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BTK gatekeeper residue variation combined with cysteine 481 substitution causes super-resistance to irreversible inhibitors acalabrutinib, ibrutinib and zanubrutinib

Comparative Analysis of BTK Inhibitors and Mechanisms Underlying Adverse Effects

Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain

Ibrutinib Has Time‐dependent On‐ and Off‐target Effects on Plasma Biomarkers and Immune Cells in Chronic Lymphocytic Leukemia

transcriptional regulator PLZF induces the development of CD44 high memory phenotype T cells

Bruton's tyrosine kinase: cell biology, sequence conservation, mutation spectrum, siRNA modifications, and expression profiling

Novel mouse model resistant to irreversible BTK inhibitors: a tool identifying new therapeutic targets and side effects

Splice-Correction Strategies for Treatment of X-Linked Agammaglobulinemia

Transcriptional signatures of Itk-deficient CD3+, CD4+ and CD8+ T-cells

Regulation of Bruton Tyrosine Kinase by the Peptidylprolyl Isomerase Pin1

Distinct gene expression signature in Btk-defective T1 B-cells

BTKbase, Bruton Tyrosine Kinase Variant Database in X-Linked Agammaglobulinemia: Looking Back and Ahead

Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model

Functional Interaction of Caveolin-1 with Bruton's Tyrosine Kinase and Bmx

Gene expression profile of B cells from Xid mice and Btk knockout mice

In BTK, phosphorylated Y223 in the SH3 domain mirrors catalytic activity, but does not influence biological function

Combination of Gatekeeper Mutations and Cysteine 481 Replacement Causes Super Resistance to the Irreversible BTK Inhibitors Ibrutinib, Acalabrutinib and Zanubrutinib

Ibrutinib induces rapid down‐regulation of inflammatory markers and altered transcription of chronic lymphocytic leukaemia‐related genes in blood and lymph nodes

Agammaglobulinemia: causative mutations and their implications for novel therapies

Defective Toll-like receptor 9-mediated cytokine production in B cells from Bruton's tyrosine kinase-deficient mice

695. Splice-Correction of X-Linked Agammaglobulinemia in a Human BAC-Transgenic Mouse Model Using Oligonucleotides

Very Early Effects of Ibrutinib on Tumor and Immune Cells in Blood and Lymph Nodes in Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) Patients

Bruton's tyrosine kinase (Btk) : function, regulation, and transformation with special emphasis on the PH domain: Kinases & Phosphatases of the Immune System

Characterization of CD44-high memory phenotype T cells induced by enforced expression of the transcription factor PLZF (85.12)

Pinning down Bruton’s tyrosine kinase (Btk) (B26)

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