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Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis

Nature medicine, 2007-11, Vol.13 (11), p.1349-1358

2007

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Activated protein C ameliorates LPS-induced acute kidney injury and downregulates renal INOS and angiotensin 2

American journal of physiology. Renal physiology, 2007-07, Vol.293 (1), p.F245-F254

2007

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Levels of protein C and soluble thrombomodulin in critically ill patients with acute kidney injury: a multicenter prospective observational study

PloS one, 2015-03, Vol.10 (3), p.e0120770-e0120770

2015

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Activated protein C decreases tumor necrosis factor related apoptosis-inducing ligand by an EPCR- independent mechanism involving Egr-1/Erk-1/2 activation

Arteriosclerosis, thrombosis, and vascular biology, 2007-12, Vol.27 (12), p.2634-2641

2007

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Soluble thrombomodulin reduces inflammation and prevents microalbuminuria induced by chronic endothelial activation in transgenic mice

American journal of physiology. Renal physiology, 2012-03, Vol.302 (6), p.F703-F712

2012

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Treatment of sepsis-induced acquired protein C deficiency reverses Angiotensin-converting enzyme-2 inhibition and decreases pulmonary inflammatory response

The Journal of pharmacology and experimental therapeutics, 2008-04, Vol.325 (1), p.17-26

2008

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Engineering the Proteolytic Specificity of Activated Protein C Improves Its Pharmacological Properties

Proceedings of the National Academy of Sciences - PNAS, 2003-04, Vol.100 (8), p.4423-4428

2003

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Soluble Thrombomodulin Protects Ischemic Kidneys

Journal of the American Society of Nephrology, 2009-03, Vol.20 (3), p.524-534

2009

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Negative Regulation of Inducible Nitric-oxide Synthase Expression Mediated through Transforming Growth Factor-β-dependent Modulation of Transcription Factor TCF11

The Journal of biological chemistry, 2007-12, Vol.282 (51), p.36837-36844

2007

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Modulation of Thrombomodulin-dependent Activation of Human Protein C through Differential Expression of Endothelial Smads

The Journal of biological chemistry, 2002-12, Vol.277 (51), p.49815-49819

2002

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Differential mechanisms of plasminogen activator inhibitor-1 gene activation by transforming growth factor-beta and tumor necrosis factor-alpha in endothelial cells

Thrombosis and haemostasis, 2001-12, Vol.86 (6), p.1563-1572

2001

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Distinct Functions of Activated Protein C Differentially Attenuate Acute Kidney Injury

Journal of the American Society of Nephrology, 2009-02, Vol.20 (2), p.267-277

2009

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FoxA2 Involvement in Suppression of Protein C, an Outcome Predictor in Experimental Sepsis

Clinical and Vaccine Immunology, 2006-03, Vol.13 (3), p.426-432

2006

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Role of protein C in renal dysfunction after polymicrobial sepsis

Journal of the American Society of Nephrology, 2007-03, Vol.18 (3), p.860-867

2007

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Enhanced Protein C Activation and Inhibition of Fibrinogen Cleavage by a Thrombin Modulator

Science (American Association for the Advancement of Science), 1996-09, Vol.273 (5280), p.1389-1391

1996

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Evaluation of protein C and other biomarkers as predictors of mortality in a rat cecal ligation and puncture model of sepsis

Critical care medicine, 2004-07, Vol.32 (7), p.1570-1578

2004

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The Puzzling Role of TRAIL in Endothelial Cell Biology

Arteriosclerosis, thrombosis, and vascular biology, 2008-02, Vol.28 (2)

2008

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Activated protein C suppresses adrenomedullin and ameliorates lipopolysaccharide-induced hypotension

Shock (Augusta, Ga.), 2007-10, Vol.28 (4), p.468-476

2007

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Smad6s Regulates Plasminogen Activator Inhibitor-1 through a Protein Kinase C-β-dependent Up-regulation of Transforming Growth Factor-β

The Journal of biological chemistry, 2005-04, Vol.280 (15), p.14943-14947

2005

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Activated protein C modulates chemokine response and tissue injury in experimental sepsis

Advances in experimental medicine and biology, 2008, Vol.614, p.83

2008

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17β-Estradiol, But Not Raloxifene, Decreases Thrombomodulin in the Antithrombotic Protein C Pathway

Endocrinology (Philadelphia), 2000-10, Vol.141 (10), p.3908-3911

2000

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NF-κB mediates amyloid β peptide-stimulated activity of the human apolipoprotein E gene promoter in human astroglial cells

Brain research. Molecular brain research., 2005-05, Vol.136 (1), p.177-188

2005

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Characterization and Novel Purification of Recombinant Human Protein C from Three Mammalian Cell Lines

Bio/technology (New York, N.Y. 1983), 1990-07, Vol.8 (7), p.655-661

1990

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The Human Apolipoprotein E Gene Is Negatively Regulated in Human Liver HepG2 Cells by the Transcription Factor BEF-1 (∗)

The Journal of biological chemistry, 1995-06, Vol.270 (26), p.15447-15450

1995

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Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk

The New England journal of medicine, 2022-11, Vol.387 (21), p.1923-1934

2022

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Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis

Activated protein C ameliorates LPS-induced acute kidney injury and downregulates renal INOS and angiotensin 2

Levels of protein C and soluble thrombomodulin in critically ill patients with acute kidney injury: a multicenter prospective observational study

Activated protein C decreases tumor necrosis factor related apoptosis-inducing ligand by an EPCR- independent mechanism involving Egr-1/Erk-1/2 activation

Soluble thrombomodulin reduces inflammation and prevents microalbuminuria induced by chronic endothelial activation in transgenic mice

Treatment of sepsis-induced acquired protein C deficiency reverses Angiotensin-converting enzyme-2 inhibition and decreases pulmonary inflammatory response

Engineering the Proteolytic Specificity of Activated Protein C Improves Its Pharmacological Properties

Soluble Thrombomodulin Protects Ischemic Kidneys

Negative Regulation of Inducible Nitric-oxide Synthase Expression Mediated through Transforming Growth Factor-β-dependent Modulation of Transcription Factor TCF11

Modulation of Thrombomodulin-dependent Activation of Human Protein C through Differential Expression of Endothelial Smads

Differential mechanisms of plasminogen activator inhibitor-1 gene activation by transforming growth factor-beta and tumor necrosis factor-alpha in endothelial cells

Distinct Functions of Activated Protein C Differentially Attenuate Acute Kidney Injury

FoxA2 Involvement in Suppression of Protein C, an Outcome Predictor in Experimental Sepsis

Role of protein C in renal dysfunction after polymicrobial sepsis

Enhanced Protein C Activation and Inhibition of Fibrinogen Cleavage by a Thrombin Modulator

Evaluation of protein C and other biomarkers as predictors of mortality in a rat cecal ligation and puncture model of sepsis

The Puzzling Role of TRAIL in Endothelial Cell Biology

Activated protein C suppresses adrenomedullin and ameliorates lipopolysaccharide-induced hypotension

Smad6s Regulates Plasminogen Activator Inhibitor-1 through a Protein Kinase C-β-dependent Up-regulation of Transforming Growth Factor-β

Activated protein C modulates chemokine response and tissue injury in experimental sepsis

17β-Estradiol, But Not Raloxifene, Decreases Thrombomodulin in the Antithrombotic Protein C Pathway

NF-κB mediates amyloid β peptide-stimulated activity of the human apolipoprotein E gene promoter in human astroglial cells

Characterization and Novel Purification of Recombinant Human Protein C from Three Mammalian Cell Lines

The Human Apolipoprotein E Gene Is Negatively Regulated in Human Liver HepG2 Cells by the Transcription Factor BEF-1 (∗)

Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk

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