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The Corrected Traditional Equations for Calculation of Hepatic Clearance that Account for the Difference in Drug Ionization in Extracellular and Intracellular Tissue Water and the Corresponding Corrected PBPK Equation

Journal of pharmaceutical sciences, 2011-03, Vol.100 (3), p.1167-1183

Berezhkovskiy, Leonid M.

2011

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Volume of Distribution at Steady State for a Linear Pharmacokinetic System with Peripheral Elimination

Journal of pharmaceutical sciences, 2004-06, Vol.93 (6), p.1628-1640

Berezhkovskiy, Leonid M.

2004

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Exploration of PBPK Model—Calculation of Drug Time Course in Tissue Using IV Bolus Drug Plasma Concentration-Time Profile and the Physiological Parameters of the Organ

Journal of pharmaceutical sciences, 2016-08, Vol.105 (8), p.2453-2458

Berezhkovskiy, Leonid M.

2016

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On the accuracy of calculation of the mean residence time of drug in the body and its volumes of distribution based on the assumption of central elimination

Xenobiotica, 2016-06, Vol.46 (6), p.477-482

Berezhkovskiy, Leonid M.

2016

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On the Calculation of the Concentration Dependence of Drug Binding to Plasma Proteins with Multiple Binding Sites of Different Affinities: Determination of the Possible Variation of the Unbound Drug Fraction and Calculation of the Number of Binding Sites of the Protein

Journal of pharmaceutical sciences, 2007-02, Vol.96 (2), p.249-257

Berezhkovskiy, Leonid M.

2007

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On the influence of protein binding on pharmacological activity of drugs

Journal of pharmaceutical sciences, 2010-04, Vol.99 (4), p.2153-2165

Berezhkovskiy, Leonid M.

2010

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Prediction of Drug Terminal Half-Life and Terminal Volume of Distribution After Intravenous Dosing Based on Drug Clearance, Steady-State Volume of Distribution, and Physiological Parameters of the Body

Journal of pharmaceutical sciences, 2013-02, Vol.102 (2), p.761-771

Berezhkovskiy, Leonid M.

2013

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Determination of Hepatic Clearance with the Account of Drug–Protein Binding Kinetics

Journal of pharmaceutical sciences, 2012-10, Vol.101 (10), p.3936-3945

Berezhkovskiy, Leonid M.

2012

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On the Accuracy of Estimation of Basic Pharmacokinetic Parameters by the Traditional Noncompartmental Equations and the Prediction of the Steady-State Volume of Distribution in Obese Patients Based Upon Data Derived from Normal Subjects

Journal of pharmaceutical sciences, 2011-06, Vol.100 (6), p.2482-2497

Berezhkovskiy, Leonid M.

2011

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On the Accuracy of a One-Compartment Approach for Determination of Drug Terminal Half-Life

Journal of pharmaceutical sciences, 2013-07, Vol.102 (7), p.2082-2084

Berezhkovskiy, Leonid M.

2013

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Conceptual underestimation of the total body clearance by the sum of clearances of individual organs in physiologically based pharmacokinetics

Journal of pharmaceutical sciences, 2012-12, Vol.101 (12), p.4660-4665

Berezhkovskiy, Leonid M.

2012

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Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase

Journal of medicinal chemistry, 2018-08, Vol.61 (15), p.6801-6813

2018

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A Valid Equation for the Well-Stirred Perfusion Limited Physiologically Based Pharmacokinetic Model that Consistently Accounts for the Blood–Tissue Drug Distribution in the Organ and the Corresponding Valid Equation for the Steady State Volume of Distribution

Journal of pharmaceutical sciences, 2010-01, Vol.99 (1), p.475-485

Berezhkovskiy, Leonid M.

2010

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The influence of hepatic transport on the distribution volumes and mean residence time of drug in the body and the accuracy of estimating these parameters by the traditional pharmacokinetic calculations

Journal of pharmaceutical sciences, 2011-11, Vol.100 (11), p.5031-5047

Berezhkovskiy, Leonid M.

2011

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Determination of drug binding to plasma proteins using competitive equilibrium binding to dextran-coated charcoal

Journal of pharmacokinetics and pharmacodynamics, 2006-10, Vol.33 (5), p.595-608

BEREZHKOVSKIY, Leonid M

2006

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On the prediction of hepatic clearance using the diluted plasma in metabolic stability assay

Journal of pharmaceutical sciences, 2009-06, Vol.98 (6), p.1922-1927

2009

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On the Accuracy of Determination of Unbound Drug Fraction in Tissue using Diluted Tissue Homogenate

Journal of pharmaceutical sciences, 2012-05, Vol.101 (5), p.1909-1916

Berezhkovskiy, Leonid M.

2012

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On the Possibility of Self-Induction of Drug Protein Binding

Journal of pharmaceutical sciences, 2010-10, Vol.99 (10), p.4400-4405

Berezhkovskiy, Leonid M.

2010

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Determination of Mean Residence Time of Drug in Plasma and the Influence of the Initial Drug Elimination and Distribution on the Calculation of Pharmacokinetic Parameters

Journal of pharmaceutical sciences, 2009-02, Vol.98 (2), p.748-762

Berezhkovskiy, Leonid M.

2009

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Some features of the kinetics and equilibrium of drug binding to plasma proteins

Expert opinion on drug metabolism & toxicology, 2008-12, Vol.4 (12), p.1479-1498

Berezhkovskiy, Leonid M

2008

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Consideration of the Linear Concentration Increase of the Unbound Drug Fraction in Plasma

Journal of pharmaceutical sciences, 2009-02, Vol.98 (2), p.383-393

Berezhkovskiy, Leonid M.

2009

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A Convenient Method to Measure Blood–Plasma Concentration Ratio Using Routine Plasma Collection in In Vivo Pharmacokinetic Studies

Journal of pharmaceutical sciences, 2011-12, Vol.100 (12), p.5293-5298

2011

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Consistency of the Novel Equations for Determination of Hepatic Clearance and Drug Time Course in Liver that Account for the Difference in Drug Ionization in Extracellular and Intracellular Tissue Water

Journal of pharmaceutical sciences, 2012-02, Vol.101 (2), p.516-518

2012

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Determination of Volume of Distribution at Steady State with Complete Consideration of the Kinetics of Protein and Tissue Binding in Linear Pharmacokinetics

Journal of pharmaceutical sciences, 2004-02, Vol.93 (2), p.364-374

Berezhkovskiy, Leonid M.

2004

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The Connection Between the Steady State (Vss) and Terminal (Vβ) Volumes of Distribution in Linear Pharmacokinetics and The General Proof That Vβ ≥ Vss

Journal of pharmaceutical sciences, 2007-06, Vol.96 (6), p.1638-1652

Berezhkovskiy, Leonid M.

2007

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The Corrected Traditional Equations for Calculation of Hepatic Clearance that Account for the Difference in Drug Ionization in Extracellular and Intracellular Tissue Water and the Corresponding Corrected PBPK Equation

Volume of Distribution at Steady State for a Linear Pharmacokinetic System with Peripheral Elimination

Exploration of PBPK Model—Calculation of Drug Time Course in Tissue Using IV Bolus Drug Plasma Concentration-Time Profile and the Physiological Parameters of the Organ

On the accuracy of calculation of the mean residence time of drug in the body and its volumes of distribution based on the assumption of central elimination

On the Calculation of the Concentration Dependence of Drug Binding to Plasma Proteins with Multiple Binding Sites of Different Affinities: Determination of the Possible Variation of the Unbound Drug Fraction and Calculation of the Number of Binding Sites of the Protein

On the influence of protein binding on pharmacological activity of drugs

Prediction of Drug Terminal Half-Life and Terminal Volume of Distribution After Intravenous Dosing Based on Drug Clearance, Steady-State Volume of Distribution, and Physiological Parameters of the Body

Determination of Hepatic Clearance with the Account of Drug–Protein Binding Kinetics

On the Accuracy of Estimation of Basic Pharmacokinetic Parameters by the Traditional Noncompartmental Equations and the Prediction of the Steady-State Volume of Distribution in Obese Patients Based Upon Data Derived from Normal Subjects

On the Accuracy of a One-Compartment Approach for Determination of Drug Terminal Half-Life

Conceptual underestimation of the total body clearance by the sum of clearances of individual organs in physiologically based pharmacokinetics

Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase

A Valid Equation for the Well-Stirred Perfusion Limited Physiologically Based Pharmacokinetic Model that Consistently Accounts for the Blood–Tissue Drug Distribution in the Organ and the Corresponding Valid Equation for the Steady State Volume of Distribution

The influence of hepatic transport on the distribution volumes and mean residence time of drug in the body and the accuracy of estimating these parameters by the traditional pharmacokinetic calculations

Determination of drug binding to plasma proteins using competitive equilibrium binding to dextran-coated charcoal

On the prediction of hepatic clearance using the diluted plasma in metabolic stability assay

On the Accuracy of Determination of Unbound Drug Fraction in Tissue using Diluted Tissue Homogenate

On the Possibility of Self-Induction of Drug Protein Binding

Determination of Mean Residence Time of Drug in Plasma and the Influence of the Initial Drug Elimination and Distribution on the Calculation of Pharmacokinetic Parameters

Some features of the kinetics and equilibrium of drug binding to plasma proteins

Consideration of the Linear Concentration Increase of the Unbound Drug Fraction in Plasma

A Convenient Method to Measure Blood–Plasma Concentration Ratio Using Routine Plasma Collection in In Vivo Pharmacokinetic Studies

Consistency of the Novel Equations for Determination of Hepatic Clearance and Drug Time Course in Liver that Account for the Difference in Drug Ionization in Extracellular and Intracellular Tissue Water

Determination of Volume of Distribution at Steady State with Complete Consideration of the Kinetics of Protein and Tissue Binding in Linear Pharmacokinetics

The Connection Between the Steady State (Vss) and Terminal (Vβ) Volumes of Distribution in Linear Pharmacokinetics and The General Proof That Vβ ≥ Vss

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